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Akademický článek

Genetic rearrangements of variable di-residue (RVD)-containing repeat arrays in a baculoviral TALEN system

Autor: Cia-Hin Lau, Haibao Zhu, Johan Chin-Kang Tay, Zhendong Li, Felix Chang Tay, Can Chen, Wee-Kiat Tan, Shouhui Du, Vic-Ki Sia, Rui-Zhe Phang, Shin-Yi Tang, Chiyun Yang, Zhixia Chi, Chieh-Ching Liang, Er Ning, Shu Wang

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)

Virus-derived gene transfer vectors have been successfully employed to express the transcription activator-like effector nucleases (TALENs) in mammalian cells. Since the DNA-binding domains of TALENs consist of the variable di-residue (RVD)-containin

Externí odkaz: https://doaj.org/article/e48b6d5d34f54c6fb140bc6cf98feafe

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Intraperitoneal immunotherapy with T cells stably and transiently expressing anti-EpCAM CAR in xenograft models of peritoneal carcinomatosis

Autor: John E. Connolly, Johan Chin-Kang Tay, Xue Hu Xu, Zhendong Li, Can Chen, Zhixia Chi, Shu Wang, Shouhui Du, Han Chong Toh, Wei Xia Ang

Publikováno v: Oncotarget

// Wei Xia Ang 1, 2, * , Zhendong Li 1, * , Zhixia Chi 1 , Shou-Hui Du 1 , Can Chen 3 , Johan C.K. Tay 1 , Han Chong Toh 4 , John E. Connolly 5 , Xue Hu Xu 6 , Shu Wang 1, 2 1 Department of Biological Sciences, National University of Singapore 117543

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a3394a08dd110b55c9a9ae77211639
http://europepmc.org/articles/PMC5355119

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Zinc Finger Nuclease-Expressing Baculoviral Vectors Mediate Targeted Genome Integration of Reprogramming Factor Genes to Facilitate the Generation of Human Induced Pluripotent Stem Cells

Autor: Rui-Zhe Phang, Wee Kiat Tan, Han Chong Toh, Johan Chin-Kang Tay, Felix Chang Tay, Zhendong Li, Sal-Lee Goh, Cia-Hin Lau, Haibao Zhu, Can Chen, Shouhui Du, Weimin Fan, Chunxiao Wu, Shu Wang, Jieming Zeng, Qingle Liang

Publikováno v: Stem Cells Translational Medicine. 2:935-945

Integrative gene transfer using retroviruses to express reprogramming factors displays high efficiency in generating induced pluripotent stem cells (iPSCs), but the value of the method is limited because of the concern over mutagenesis associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87692140c008d4085bd42e97a10f4b4a
https://doi.org/10.5966/sctm.2013-0043

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Targeted transgene insertion into theAAVS1locus driven by baculoviral vector-mediated zinc finger nuclease expression in human-induced pluripotent stem cells

Autor: Wee Kiat Tan, Shouhui Du, Haibao Zhu, Can Chen, Rui Zhe Phang, Cia-Hin Lau, Sal-Lee Goh, Shu Wang, Felix Chang Tay, Mohammad Shahbazi, Weimin Fan, Chrishan J A Ramachandra

Publikováno v: The Journal of Gene Medicine. 15:384-395

Background The AAVS1 locus is viewed as a ‘safe harbor’ for transgene insertion into human genome. In the present study, we report a new method for AAVS1 targeting in human-induced pluripotent stem cells (hiPSCs). Methods We have developed two ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca9194ab3850b23c50994d2e697c2cb4
https://doi.org/10.1002/jgm.2745

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Inhibition of neuronal nitric oxide synthase activity promotes migration of human-induced pluripotent stem cell-derived neural stem cells toward cancer cells

Autor: Sally S. L. Goh, Jing Yang, Weimin Fan, Wee Kiat Tan, Shouhui Du, Can Chen, Dang Hoang Lam, Yukti Choudhury, Shu Wang, Felix Chang Tay, Yovita Ida Purwanti, Yi Wang

Publikováno v: Journal of Neurochemistry. 126:318-330

The breakthrough in derivation of human-induced pluripotent stem cells (hiPSCs) provides an approach that may help overcome ethical and allergenic challenges posed in numerous medical applications involving human cells, including neural stem/progenit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aabad0ab24de2ae7f04b20c9307be66
https://doi.org/10.1111/jnc.12199

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Co-Expansion of Cytokine-Induced Killer Cells and Vγ9Vδ2 T Cells for CAR T-Cell Therapy

Autor: Xuehu Xu, Zhixia Chi, Can Chen, Shu Wang, Timothy Weixin Kwang, Wee Kiat Tan, Shouhui Du, Zhendong Li

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0161820 (2016)

Gamma delta (γδ) T cells and cytokine-induced killer (CIK) cells, which are a heterogeneous population of T lymphocytes and natural killer T (NKT) cells, have been separately expanded ex vivo and shown to be capable of targeting and mediating cytot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef53a6906e1d4c277e408d69a74265f4
http://europepmc.org/articles/PMC5012695

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Akademický článek

Geometric Stochastic Resonance in an Asymmetric T-Shaped Chamber

Autor: Shouhui Duan, Bixuan Fan, Zhenglu Duan

Publikováno v: Symmetry, Vol 15, Iss 12, p 2183 (2023)

The investigation of a Brownian particle subjected to an AC force that diffuses within a T-shaped chamber was conducted. This T-shaped chamber is composed of a strip cavity and a trapezoidal cavity positioned below it. The interplay between the AC fo

Externí odkaz: https://doaj.org/article/f402390df137467796be438d268a39b3

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Retracted: Tumor Tropism of Intravenously Injected Human‐Induced Pluripotent Stem Cell‐Derived Neural Stem Cells and Their Gene Therapy Application in a Metastatic Breast Cancer Model

Autor: Jing Yang, Wai Hoe Ng, Sally S. L. Goh, Dang Hoang Lam, Can Chen, Chee Kian Tham, Ying Zhao, Mohammad Shahbazi, Shouhui Du, Shu Wang, Han Chong Toh, Felix Chang Tay, Esther Lee, Ghayathri Balasundaram

Publikováno v: STEM CELLS. 30:1021-1029

Human pluripotent stem cells can serve as an accessible and reliable source for the generation of functional human cells for medical therapies. In this study, we used a conventional lentiviral transduction method to derive human-induced pluripotent s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f75f0a6fd6865ef37d09d01e61dc26c
https://doi.org/10.1002/stem.1051

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Targeted transgene insertion into the AAVS1 locus driven by baculoviral vector-mediated zinc finger nuclease expression in human-induced pluripotent stem cells

Autor: Felix Chang, Tay, Wee Kiat, Tan, Sal-Lee, Goh, Chrishan J A, Ramachandra, Cia-Hin, Lau, Haibao, Zhu, Can, Chen, Shouhui, Du, Rui Zhe, Phang, Mohammad, Shahbazi, Weimin, Fan, Shu, Wang

Publikováno v: The journal of gene medicine. 15(10)

The AAVS1 locus is viewed as a 'safe harbor' for transgene insertion into human genome. In the present study, we report a new method for AAVS1 targeting in human-induced pluripotent stem cells (hiPSCs).We have developed two baculoviral transduction s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36113ffec131f8a2652b0478cb4b6dc8
https://pubmed.ncbi.nlm.nih.gov/24105820

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Genetic rearrangements of variable di-residue (RVD)-containing repeat arrays in a baculoviral TALEN system

Autor: Vic-Ki Sia, Zhixia Chi, Rui-Zhe Phang, Haibao Zhu, Can Chen, Er Ning, Shin-Yi Tang, Chieh-Ching Liang, Wee Kiat Tan, Cia-Hin Lau, Felix Chang Tay, Johan Chin-Kang Tay, Zhendong Li, Chiyun Yang, Shouhui Du, Shu Wang

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50d5dbb299d5ea5e067905b40e5babd
https://doi.org/10.1038/mtm.2014.50

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