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The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh Plasmodium falciparum isolates.

Autor: Okitwi M; Infectious Diseases Research Collaboration, Kampala, Uganda., Shoue DA; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Checkley LA; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Orena S; Infectious Diseases Research Collaboration, Kampala, Uganda., Ceja FG; Dominican University of California, San Rafael, California, USA., Taremwa Y; Infectious Diseases Research Collaboration, Kampala, Uganda., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Katairo T; Infectious Diseases Research Collaboration, Kampala, Uganda., Byaruhanga O; Infectious Diseases Research Collaboration, Kampala, Uganda., Sievert MA; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Garg S; University of California, San Francisco, California, USA., Kreutzfeld OK; University of California, San Francisco, California, USA., Legac J; University of California, San Francisco, California, USA., Bailey JA; Brown University, Providence, Rhode Island, USA., Nsobya SL; Infectious Diseases Research Collaboration, Kampala, Uganda., Conrad MD; University of California, San Francisco, California, USA., Rosenthal PJ; University of California, San Francisco, California, USA., Ferdig MT; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Cooper RA; Dominican University of California, San Rafael, California, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Nov 15, pp. e0118324. Date of Electronic Publication: 2024 Nov 15.

A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance.

Autor: Kane J; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Li X; Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, USA., Kumar S; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA., Button-Simons KA; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Vendrely Brenneman KM; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Dahlhoff H; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Sievert MAC; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Checkley LA; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Shoue DA; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Singh PP; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA., Abatiyow BA; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA., Haile MT; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA., Nair S; Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, USA., Reyes A; Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, USA., Tripura R; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine Research Building, University of Oxford Old Road Campus, Oxford, United Kingdom., Peto TJ; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine Research Building, University of Oxford Old Road Campus, Oxford, United Kingdom., Lek D; National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.; School of Public Health, National Institute of Public Health, Phnom Penh, Cambodia., Mukherjee A; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.; Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, Notre Dame, Indiana, USA., Kappe SHI; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.; Department of Pediatrics, University of Washington, Seattle, Washington, USA., Dhorda M; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine Research Building, University of Oxford Old Road Campus, Oxford, United Kingdom., Nkhoma SC; BEI Resources, American Type Culture Collection (ATCC), Manassas, Virginia, USA., Cheeseman IH; Host Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, USA., Vaughan AM; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.; Department of Pediatrics, University of Washington, Seattle, Washington, USA., Anderson TJC; Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, USA., Ferdig MT; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.

Publikováno v: MBio [mBio] 2024 Jul 17; Vol. 15 (7), pp. e0080524. Date of Electronic Publication: 2024 Jun 24.

Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1.

Autor: Amambua-Ngwa A; MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia., Button-Simons KA; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA., Li X; Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, TX, USA., Kumar S; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Brenneman KV; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA., Ferrari M; Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, TX, USA., Checkley LA; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA., Haile MT; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Shoue DA; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA., McDew-White M; Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, TX, USA., Tindall SM; School of Life Sciences, University of Nottingham, Nottingham, UK., Reyes A; Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, TX, USA., Delgado E; Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, TX, USA., Dalhoff H; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA., Larbalestier JK; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA., Amato R; Wellcome Sanger Institute, Hinxton, UK., Pearson RD; Wellcome Sanger Institute, Hinxton, UK., Taylor AB; Department of Biochemistry & Structural Biology, University of Texas Health Science Center at San Antonio, Antonio, TX, USA., Nosten FH; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., D'Alessandro U; MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia., Kwiatkowski D; Wellcome Sanger Institute, Hinxton, UK., Cheeseman IH; Host Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX, USA., Kappe SHI; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Avery SV; School of Life Sciences, University of Nottingham, Nottingham, UK., Conway DJ; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Vaughan AM; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA. Ashley.Vaughan@seattlechildrens.org.; Department of Pediatrics, University of Washington, Seattle, WA, USA. Ashley.Vaughan@seattlechildrens.org., Ferdig MT; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. ferdig.1@nd.edu., Anderson TJC; Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, TX, USA. tanderso@txbiomed.org.

Publikováno v: Nature microbiology [Nat Microbiol] 2023 Jul; Vol. 8 (7), pp. 1213-1226. Date of Electronic Publication: 2023 May 11.