Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells

Autor: Yi-Tsen Kuo, Wei-Che Tseng, Ching Yuh Chern, Shou-Jhen Liou, Chin-Chuan Chen, Ying-Chih Chi, Ya-Chen Chiu, Yi-Chen Li, Pei-Ya Lin, Shih-Ting Tseng, Chi-Yuan Chen, Shu-Fang Cheng, Wen-Chih Lee, Chu-An Wang

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4422, p 4422 (2021)

BRCA mutation, one of the most common types of mutations in breast and ovarian cancer, has been suggested to be synthetically lethal with depletion of RAD52. Pharmacologically inhibiting RAD52 specifically eradicates BRCA-deficient cancer cells. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef40fad29bb380b87c3a04be15f80023
https://pubmed.ncbi.nlm.nih.gov/33922657