Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shotaro Miura"'
Autor:
Atsunobu, Sagara, Shotaro, Miura, Akinori, Kobinata, Risa, Naganawa, Saki, Yaginuma, Suguru, Saito, Rintaro, Saito, Hidenori, Kominato, Tetsuro, Yumoto, Fumiaki, Sato
Publikováno v:
Biochemical and Biophysical Research Communications. 642:145-153
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a high probability of metastasis and a lack of specific targets and targeted therapeutics. Previously, we have reported that COL8A1, which is highly expressed i
Autor:
Fumiaki Sato, Atsunobu Sagara, Kaede Tajima, Shotaro Miura, Kenjiro Inaba, Yusuke Ando, Teruaki Oku, Takashi Murakami, Yoshinori Kato, Tetsuro Yumoto
Publikováno v:
Breast Cancer Research and Treatment. 194:243-256
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes, and treatment options are limited because of the lack of signature molecules and heterogeneous properties of cancer. COL8A1 expression is higher in breast canc
Autor:
Makoto Kanematsu, Koichiro Fukuda, Tetsuji Kawamoto, David G. Cork, Shinichi Masada, Hirotsugu Usutani, Shotaro Miura
Publikováno v:
Organic & Biomolecular Chemistry. 17:8166-8174
Continuous flow-flash synthesis of a 2-bromobenzaldehyde derivative 18 as a key intermediate of a novel cholinergic muscarinic M1 positive allosteric modulator 1 bearing an isoindolin-1-one ring system as a pharmacophore has been achieved using flow
Autor:
Shotaro, Miura, Koichiro, Fukuda, Shinichi, Masada, Hirotsugu, Usutani, Makoto, Kanematsu, David G, Cork, Tetsuji, Kawamoto
Publikováno v:
Organicbiomolecular chemistry. 17(35)
Continuous flow-flash synthesis of a 2-bromobenzaldehyde derivative 18 as a key intermediate of a novel cholinergic muscarinic M
Autor:
Ryuji Nakao, Balázs Gulyás, Vladimir Stepanov, Christer Halldin, Haruhide Kimura, Shotaro Miura, Akihiro Takano, Nahid Amini, Takahiko Taniguchi
Publikováno v:
Synapse. 69:345-355
Phosphodiesterase 10A (PDE10A) is considered to be a key target for the treatment of several neuropsychiatric diseases. The characteristics of [11C]T-773, a novel positron emission tomography (PET) radioligand with high binding affinity and selectivi
Autor:
Tomoaki Hasui, Nahid Amini, Takanobu Kuroita, Christer Halldin, Ryuji Nakao, Vladimir Stepanov, Akihiro Takano, Shotaro Miura, Kosuke Nakashima, Takahiko Taniguchi, Haruhide Kimura
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 58:202-208
Phosphodiesterase 10A (PDE10A) is a member of the PDE family of enzymes that degrades cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Our aim was to label a series of structurally related PDE10A inhibitors with carbon
Autor:
Akina Harada, Kazunori Suzuki, Naomi Kamiguchi, Haruhide Kimura, Christer Halldin, Tomoaki Hasui, Shotaro Miura, Akihiro Takano, Takahiko Taniguchi, Vladimir Stepanov, Tsuyoshi Ishii, Takanobu Kuroita
Publikováno v:
Nuclear Medicine and Biology. 42:146-154
Introduction Phosphodiesterase 10A (PDE10A) is a dual-substrate PDE that hydrolyzes both cAMP and cGMP and is selectively expressed in striatal medium spiny neurons. Recent studies have suggested that PDE10A inhibition is a novel approach for the tre
Autor:
Tomoaki Hasui, Christer Halldin, Nahid Amini, Ryuji Nakao, Takahiko Taniguchi, Akihiro Takano, Vladimir Stepanov, Shotaro Miura, Haruhide Kimura
Publikováno v:
Nuclear medicine and biology. 57
Introduction Phosphodiesterase 10A (PDE10A) is a member of the PDE enzyme family that degrades cyclic adenosine and guanosine monophosphates (cAMP and cGMP). Based on the successful development of [ 11 C]T-773 as PDE10A positron emission tomography (
Publikováno v:
European Journal of Pharmacology. 723:108-115
We aimed to elucidate the mechanism underlying the anti-dyslipidemic effect of compound-T3, a farnesoid X receptor antagonist, by investigating its effects on hepatic lipid metabolism in non-human primates. We administered lipid-lowering drugs for 7
Autor:
Nahid Amini, Balázs Gulyás, Shotaro Miura, Akihiro Takano, Haruhide Kimura, Takahiko Taniguchi, Jenny Häggkvist, Miklós Tóth, Christer Halldin, Vladimir Stepanov, Ryuji Nakao
Publikováno v:
Molecular imaging and biology. 17(4)
[(11)C]T-773 is a new radioligand for positron emission tomography (PET) targeting the phosphodiesterase 10A enzyme (PDE10A). PDE10A is highly expressed in the striatum by medium spiny neurons, and it has been demonstrated to be involved in the regul