Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Shotaro Kamata"'
Autor:
Shotaro Kamata, Akihiro Honda, Nonoka Kashiwagi, Ayumi Shimamura, Sayaka Yashiro, Yuna Komori, Aoi Hosoda, Noriyuki Akahoshi, Isao Ishii
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 624 (2024)
Three peroxisome proliferator-activated receptor subtypes, PPARα, PPAR(ß/)δ, and PPARγ, exert ligand-dependent transcriptional control in concert with retinoid X receptors (RXRs) on various gene sets harboring PPAR response elements (PPREs) in th
Externí odkaz:
https://doaj.org/article/e0100f18dab94f4cb159c0659b44680b
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1264 (2023)
The number of patients with nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) is increasing globally and is raising serious concerns regarding the increasing medical and economic burden incurred for their treatment. The pro
Externí odkaz:
https://doaj.org/article/1c08f3f259e84fa99d6471d3aa221987
Autor:
Shotaro Kamata, Akihiro Honda, Ryo Ishikawa, Makoto Akahane, Ayane Fujita, Chihiro Kaneko, Saeka Miyawaki, Yuki Habu, Yui Shiiyama, Kie Uchii, Yui Machida, Takuji Oyama, Isao Ishii
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1523 (2023)
No therapeutic drugs are currently available for nonalcoholic steatohepatitis (NASH) that progresses from nonalcoholic fatty liver via oxidative stress-involved pathways. Three cognate peroxisome proliferator-activated receptor (PPAR) subtypes (PPAR
Externí odkaz:
https://doaj.org/article/0accaf46209a47e383198c9c9eddc003
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100364- (2021)
Summary: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor-type transcription factors with three subtypes (α, δ, and γ) that regulate cell differentiation and metabolism. Co-crystals of human PPARα-ligand-binding domain (LB
Externí odkaz:
https://doaj.org/article/53ce7e7731544411be941c2d5ade6d26
Autor:
Akihiro Honda, Shotaro Kamata, Makoto Akahane, Yui Machida, Kie Uchii, Yui Shiiyama, Yuki Habu, Saeka Miyawaki, Chihiro Kaneko, Takuji Oyama, Isao Ishii
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4726 (2022)
Among the agonists against three peroxisome proliferator-activated receptor (PPAR) subtypes, those against PPARα (fibrates) and PPARγ (glitazones) are currently used to treat dyslipidemia and type 2 diabetes, respectively, whereas PPARδ agonists a
Externí odkaz:
https://doaj.org/article/81f5a994fd9540b9af50f73bc322649c
Autor:
Shotaro Kamata, Junya Yamamoto, Haruka Ohtani, Yuka Tosaka, Sayumi Yoshikawa, Noriyuki Akahoshi, Isao Ishii
Publikováno v:
FEBS Open Bio, Vol 8, Iss 9, Pp 1524-1543 (2018)
Overnight fasting is a routine procedure before surgery in clinical settings. Intermittent fasting is the most common diet/fitness trend implemented for weight loss and the treatment of lifestyle‐related diseases. In either setting, the effects not
Externí odkaz:
https://doaj.org/article/ea059c6dca5b4c3eaed59c9be4cf3e32
Autor:
Shotaro Kamata, Takuji Oyama, Kenta Saito, Akihiro Honda, Yume Yamamoto, Keisuke Suda, Ryo Ishikawa, Toshimasa Itoh, Yasuo Watanabe, Takahiro Shibata, Koji Uchida, Makoto Suematsu, Isao Ishii
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101727- (2020)
Summary: Most triacylglycerol-lowering fibrates have been developed in the 1960s–1980s before their molecular target, peroxisome proliferator-activated receptor alpha (PPARα), was identified. Twenty-one ligand-bound PPARα structures have been dep
Externí odkaz:
https://doaj.org/article/019e9a2e669140bd9f38f82355fbf354
Autor:
Isao Ishii, Shotaro Kamata, Saki Ito, Aya Shimonaga, Maika Koizumi, Maiko Tsushima, Asumi Miura, Tomoko Nagata, Yuka Tosaka, Haruka Ohtani, Waka Kamichatani, Noriyuki Akahoshi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 928 (2022)
Methionine (Met) is considered the most toxic amino acid in mammals. Here, we investigated biochemical and behavioral impacts of ad libitum one-week feeding of high-Met diets on mice. Adult male mice were fed the standard rodent diet that contained 0
Externí odkaz:
https://doaj.org/article/e09a1e8ec34c4a1195dee00322eb5a49
Autor:
Noriyuki Akahoshi, Tatsuro Minakawa, Masashi Miyashita, Uran Sugiyama, Chihiro Saito, Rintaro Takemoto, Akihiro Honda, Waka Kamichatani, Shotaro Kamata, Yasumi Anan, Isao Ishii
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 818 (2020)
Mercaptopyruvate sulfurtransferase (Mpst) and its homolog thiosulfate sulfurtransferase (Tst = rhodanese) detoxify cyanide to thiocyanate. Mpst is attracting attention as one of the four endogenous hydrogen sulfide (H2S)/reactive sulfur species (RSS)
Externí odkaz:
https://doaj.org/article/1a9d6d6c11a048ac9a255807cabcf507
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 357-368 (2015)
Dietary or caloric restriction confers various clinical benefits. Short‐term fasting of mice is a common experimental procedure that may involve systemic metabolic remodeling, which may significantly affect experimental outputs. This study evaluate
Externí odkaz:
https://doaj.org/article/3196b720ddc64784a50410a33c6d5c1f