Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shotaro, Miura"'
Autor:
Atsunobu, Sagara, Shotaro, Miura, Akinori, Kobinata, Risa, Naganawa, Saki, Yaginuma, Suguru, Saito, Rintaro, Saito, Hidenori, Kominato, Tetsuro, Yumoto, Fumiaki, Sato
Publikováno v:
Biochemical and Biophysical Research Communications. 642:145-153
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a high probability of metastasis and a lack of specific targets and targeted therapeutics. Previously, we have reported that COL8A1, which is highly expressed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac8ec83fdfb68ac9c67eb6d609b49e7
https://doi.org/10.1016/j.bbrc.2022.12.046
https://doi.org/10.1016/j.bbrc.2022.12.046
Autor:
Fumiaki Sato, Atsunobu Sagara, Kaede Tajima, Shotaro Miura, Kenjiro Inaba, Yusuke Ando, Teruaki Oku, Takashi Murakami, Yoshinori Kato, Tetsuro Yumoto
Publikováno v:
Breast Cancer Research and Treatment. 194:243-256
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes, and treatment options are limited because of the lack of signature molecules and heterogeneous properties of cancer. COL8A1 expression is higher in breast canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7f98d1d79ff02b57c7301f50b4e90b
https://doi.org/10.1007/s10549-022-06635-y
https://doi.org/10.1007/s10549-022-06635-y
Autor:
Makoto Kanematsu, Koichiro Fukuda, Tetsuji Kawamoto, David G. Cork, Shinichi Masada, Hirotsugu Usutani, Shotaro Miura
Publikováno v:
Organic & Biomolecular Chemistry. 17:8166-8174
Continuous flow-flash synthesis of a 2-bromobenzaldehyde derivative 18 as a key intermediate of a novel cholinergic muscarinic M1 positive allosteric modulator 1 bearing an isoindolin-1-one ring system as a pharmacophore has been achieved using flow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb389d09fa134081045ffd9fc9cfb09
https://doi.org/10.1039/c9ob01718f
https://doi.org/10.1039/c9ob01718f
Autor:
Shotaro, Miura, Koichiro, Fukuda, Shinichi, Masada, Hirotsugu, Usutani, Makoto, Kanematsu, David G, Cork, Tetsuji, Kawamoto
Publikováno v:
Organicbiomolecular chemistry. 17(35)
Continuous flow-flash synthesis of a 2-bromobenzaldehyde derivative 18 as a key intermediate of a novel cholinergic muscarinic M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84ae116701def7529a8e6a4961e98e79
https://pubmed.ncbi.nlm.nih.gov/31464336
https://pubmed.ncbi.nlm.nih.gov/31464336
Autor:
Ryuji Nakao, Balázs Gulyás, Vladimir Stepanov, Christer Halldin, Haruhide Kimura, Shotaro Miura, Akihiro Takano, Nahid Amini, Takahiko Taniguchi
Publikováno v:
Synapse. 69:345-355
Phosphodiesterase 10A (PDE10A) is considered to be a key target for the treatment of several neuropsychiatric diseases. The characteristics of [11C]T-773, a novel positron emission tomography (PET) radioligand with high binding affinity and selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd71a2a4b444a21a045a63dd030270a
https://doi.org/10.1002/syn.21821
https://doi.org/10.1002/syn.21821
Autor:
Tomoaki Hasui, Nahid Amini, Takanobu Kuroita, Christer Halldin, Ryuji Nakao, Vladimir Stepanov, Akihiro Takano, Shotaro Miura, Kosuke Nakashima, Takahiko Taniguchi, Haruhide Kimura
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 58:202-208
Phosphodiesterase 10A (PDE10A) is a member of the PDE family of enzymes that degrades cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Our aim was to label a series of structurally related PDE10A inhibitors with carbon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4b1df92eabaa047d2f524dd4e84c506
https://doi.org/10.1002/jlcr.3284
https://doi.org/10.1002/jlcr.3284
Autor:
Akina Harada, Kazunori Suzuki, Naomi Kamiguchi, Haruhide Kimura, Christer Halldin, Tomoaki Hasui, Shotaro Miura, Akihiro Takano, Takahiko Taniguchi, Vladimir Stepanov, Tsuyoshi Ishii, Takanobu Kuroita
Publikováno v:
Nuclear Medicine and Biology. 42:146-154
Introduction Phosphodiesterase 10A (PDE10A) is a dual-substrate PDE that hydrolyzes both cAMP and cGMP and is selectively expressed in striatal medium spiny neurons. Recent studies have suggested that PDE10A inhibition is a novel approach for the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16da50c5b394f3f3f37ed12757332689
https://doi.org/10.1016/j.nucmedbio.2014.09.005
https://doi.org/10.1016/j.nucmedbio.2014.09.005
Autor:
Tomoaki Hasui, Christer Halldin, Nahid Amini, Ryuji Nakao, Takahiko Taniguchi, Akihiro Takano, Vladimir Stepanov, Shotaro Miura, Haruhide Kimura
Publikováno v:
Nuclear medicine and biology. 57
Introduction Phosphodiesterase 10A (PDE10A) is a member of the PDE enzyme family that degrades cyclic adenosine and guanosine monophosphates (cAMP and cGMP). Based on the successful development of [ 11 C]T-773 as PDE10A positron emission tomography (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70696e7dc5d7b53341b9bf513d2d37d0
https://pubmed.ncbi.nlm.nih.gov/29223715
https://pubmed.ncbi.nlm.nih.gov/29223715
Publikováno v:
European Journal of Pharmacology. 723:108-115
We aimed to elucidate the mechanism underlying the anti-dyslipidemic effect of compound-T3, a farnesoid X receptor antagonist, by investigating its effects on hepatic lipid metabolism in non-human primates. We administered lipid-lowering drugs for 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c928445b9bebb28b8c57c7b4e57dd056
https://doi.org/10.1016/j.ejphar.2013.10.048
https://doi.org/10.1016/j.ejphar.2013.10.048
Autor:
Nahid Amini, Balázs Gulyás, Shotaro Miura, Akihiro Takano, Haruhide Kimura, Takahiko Taniguchi, Jenny Häggkvist, Miklós Tóth, Christer Halldin, Vladimir Stepanov, Ryuji Nakao
Publikováno v:
Molecular imaging and biology. 17(4)
[(11)C]T-773 is a new radioligand for positron emission tomography (PET) targeting the phosphodiesterase 10A enzyme (PDE10A). PDE10A is highly expressed in the striatum by medium spiny neurons, and it has been demonstrated to be involved in the regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac896ce8ed886ea50f06980c24f3b748
https://pubmed.ncbi.nlm.nih.gov/25622810
https://pubmed.ncbi.nlm.nih.gov/25622810