Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Shota Nakamichi"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Loss-of-function mutations in an enzyme of unknown function, PNPLA1, cause dry and scaling skin in humans. Here Ohnoet al. show that PNPLA1 is a transacylase that acts in the final step of acylceramide production- esterification between ω-hydroxycer
Externí odkaz:
https://doaj.org/article/29388e6c378f489aaa22f8efa70254cf
Publikováno v:
Journal of Dermatological Science. 92:245-253
Background ABHD5 mutations cause Chanarin–Dorfman syndrome accompanied by ichthyosis. ω- O -Acylceramide (acylceramide) is essential for skin permeability barrier formation. Acylceramide production is impaired in Abhd5 knockout mice. The transacyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e8762fb473e485ea010485c4a7ea1f
https://doi.org/10.1016/j.jdermsci.2018.11.005
https://doi.org/10.1016/j.jdermsci.2018.11.005
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Nature Communications
Nature Communications
Lipids are the primary components of the skin permeability barrier, which is the body's most powerful defensive mechanism against pathogens. Acylceramide (ω-O-acylceramide) is a specialized lipid essential for skin barrier formation. Here, we identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773ffd9ae5b055e965f04a0363446f85
https://doaj.org/article/29388e6c378f489aaa22f8efa70254cf
https://doaj.org/article/29388e6c378f489aaa22f8efa70254cf
Autor:
Nozomi Kamiyama, Hisashi Tsujimura, Junko Ishikawa, Kazumitsu Sugiura, Masashi Akiyama, Shota Nakamichi, Yusuke Ohno, Akio Kihara, Ayano Naoe, Urara Yokose, Aya Ohkuni
A skin permeability barrier is essential for terrestrial animals, and its impairment causes several cutaneous disorders such as ichthyosis and atopic dermatitis. Although acylceramide is an important lipid for the skin permeability barrier, details o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069dadd68354278cd3dca09a7f022aae
https://europepmc.org/articles/PMC4485105/
https://europepmc.org/articles/PMC4485105/
Autor:
Yusuke Ohnoa, Shota Nakamichi, Aya Ohkuni, Nozomi Kamiyama, Ayano Naoe, Hisashi Tsujimura, Urara Yokose, Kazumitsu Sugiura, Junko Ishikawa, Masashi Akiyama, Akio Kihara
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/23/2015, Vol. 112 Issue 25, p7707-7712, 6p