Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shota Kurotsu"'
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101122- (2022)
Summary: Direct cardiac reprogramming, in which fibroblasts are converted into induced cardiomyocytes (iCMs) with cardiogenic transcription factors, may be a promising approach for myocardial regeneration. Here, we present a protocol for cardiac repr
Externí odkaz:
https://doaj.org/article/d0e882b0cf6a4cb5b52ff3241c04a09f
Autor:
Naoto Muraoka, Kaori Nara, Fumiya Tamura, Hidenori Kojima, Hiroyuki Yamakawa, Taketaro Sadahiro, Kazutaka Miyamoto, Mari Isomi, Sho Haginiwa, Hidenori Tani, Shota Kurotsu, Rina Osakabe, Satoru Torii, Shigeomi Shimizu, Hideyuki Okano, Yukihiko Sugimoto, Keiichi Fukuda, Masaki Ieda
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Fibroblasts can be directly reprogrammed to cardiomyocytes, but reprogramming is less efficient for adult compared to embryonic fibroblasts. Here, the authors find that inhibition of inflammation and Cox-2-prostaglandin-cAMP-IL-1β signaling enhances
Externí odkaz:
https://doaj.org/article/4512bbbc6b27484c935815f0bf1702ee
Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice
Autor:
Ken-ichiro Tanaka, Tomomi Niino, Tomoaki Ishihara, Ayaka Takafuji, Takahiro Takayama, Yuki Kanda, Toshifumi Sugizaki, Fumiya Tamura, Shota Kurotsu, Masahiro Kawahara, Tohru Mizushima
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-β1 is implicated in this activation. In this study, we screened for c
Externí odkaz:
https://doaj.org/article/e655d241e86147c782e24d9512684d35
Autor:
Fumiya Tamura, Shota Kurotsu, Yuto Abe, Masaki Ieda, Keiichi Fukuda, Takeshi Suzuki, Ichiro Harada, Hiroyuki Yamakawa, Taketaro Sadahiro, Ryo Fujita, Hidenori Kojima, Yu Yamada, Yoshiko Murakata, Naoto Muraoka, Tatsuya Akiyama, Hidenori Tani, Mari Isomi
Publikováno v:
Stem Cell Reports
Summary Direct cardiac reprogramming holds great potential for regenerative medicine. However, it remains inefficient, and induced cardiomyocytes (iCMs) generated in vitro are less mature than those in vivo, suggesting that undefined extrinsic factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f90bd91daac0e514c4de67346e3307c
https://tsukuba.repo.nii.ac.jp/records/2001632
https://tsukuba.repo.nii.ac.jp/records/2001632
Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice
Autor:
Shota Kurotsu, Toshifumi Sugizaki, Tomoaki Ishihara, Ken Ichiro Tanaka, Yuki Kanda, Fumiya Tamura, Masahiro Kawahara, Tomomi Niino, Ayaka Takafuji, Takahiro Takayama, Tohru Mizushima
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-β1 is implicated in this activation. In this study, we screened for chemicals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d900a4028e98f2f237c9c4526dc22cd
https://doaj.org/article/e655d241e86147c782e24d9512684d35
https://doaj.org/article/e655d241e86147c782e24d9512684d35
Autor:
Keiichi Fukuda, Mari Isomi, Fumiya Tamura, Masaki Ieda, Shota Kurotsu, Taketaro Sadahiro, Noriko Miyake, Sho Haginiwa, Koichi Miyake, Naoto Muraoka, Hidenori Tani, Hidenori Kojima
Publikováno v:
Biochemical and biophysical research communications. 513(4)
Cardiovascular disease is a leading cause of death worldwide. Mammalian cardiomyocytes (CMs) proliferate during embryonic development, whereas they largely lose their regenerative capacity after birth. Defined factors expressed in cardiac progenitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9894e315002df8b5ad4f12628c62c6
https://pubmed.ncbi.nlm.nih.gov/31010673
https://pubmed.ncbi.nlm.nih.gov/31010673
Autor:
Sho Haginiwa, Hidenori Kojima, Fumiya Tamura, Yoshifumi Kawamura, Hiroyuki Miyoshi, Kensaku Murano, Shota Kurotsu, Mayumi Oda, Mari Isomi, Masaki Ieda, Peter Andersen, Naoki Goshima, Naoto Muraoka, Taketaro Sadahiro, Hidenori Tani, Hideki Uosaki, Shugo Tohyama, Kuniaki Saito, Hirofumi Nishizono, Keiichi Fukuda, Jun Fujita, Chulan Kwon, Yuka W. Iwasaki
The mesoderm arises from pluripotent epiblasts and differentiates into multiple lineages; however, the underlying molecular mechanisms are unclear. Tbx6 is enriched in the paraxial mesoderm and is implicated in somite formation, but its function in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2646c18828a2bb77ad6b2da1f0c9236
https://europepmc.org/articles/PMC6190602/
https://europepmc.org/articles/PMC6190602/
Autor:
Ken-Ichiro Tanaka1, Shota Kurotsu1, Teita Asano1, Naoki Yamakawa1, Daisuke Kobayashi1, Yasunobu Yamashita1, Hiroshi Yamazaki1, Tomoaki Ishihara1, Hiroshi Watanabe2, Toru Maruyama2, Hidekazu Suzuki3, Tohru Mizushima1 mizushima-th@pha.keio.ac.jp
Publikováno v:
Scientific Reports. 3/28/2014, p1-11. 11p.
Autor:
Masatsugu Ema, Shota Kurotsu, Hidenori Kojima, Masaki Ieda, Keiichi Fukuda, Rina Osakabe, Sho Haginiwa, Kaori Nara, Takeshi Suzuki, Yoshiaki Kubota, Hidenori Tani, Taketaro Sadahiro, Naoto Muraoka, Fumiya Tamura, Mari Isomi
Publikováno v:
Biochemical and biophysical research communications. 495(1)
The coronary vascular system is critical for myocardial growth and cardiomyocyte survival. However, the molecular mechanism regulating coronary angiogenesis remains elusive. Vascular endothelial growth factor (VEGF) regulates angiogenesis by binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc3c96628a63781adcb11e4c87efacf
https://pubmed.ncbi.nlm.nih.gov/29158084
https://pubmed.ncbi.nlm.nih.gov/29158084
Autor:
Teita Asano, Arata Azuma, Tomomi Niino, Toshifumi Sugizaki, Hidekazu Suzuki, Ken Ichiro Tanaka, Tohru Mizushima, Shota Kurotsu
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:79-88
Idiopathic pulmonary fibrosis is thought to involve lung injury caused by reactive oxygen species (ROS), which in turn is followed by abnormal fibrosis. A transforming growth factor (TGF)-β1-induced increase in myofibroblast number plays an importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00764984404b914ff67ec9cf4fdc9677
https://doi.org/10.1124/jpet.114.213009
https://doi.org/10.1124/jpet.114.213009