Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Shota Kudo"'
Publikováno v:
Earth, Planets and Space, Vol 75, Iss 1, Pp 1-19 (2023)
Abstract After the 2011 M w 9.0 Tohoku earthquake, seismicity became extremely active throughout Japan. Despite enormous efforts to detect the large number of earthquakes, microearthquakes (M 920,000 earthquakes from March 2011 to February 2012, trip
Externí odkaz:
https://doaj.org/article/c36c4d953a924cf3809704fc2f4219d5
Publikováno v:
Earth, Planets and Space, Vol 76, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/47e94ae873104efaa4a59e1f084c4ef9
Autor:
Akinobu Senoo, Sho Ito, Satoru Nagatoishi, Yutaro Saito, Go Ueno, Daisuke Kuroda, Kouhei Yoshida, Takumi Tashima, Shota Kudo, Shinsuke Sando, Kouhei Tsumoto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Senoo et al. describe a chemical fragment that disrupts dimerization of P-cadherin. In doing so, this fragment inhibits cadherin-mediated cell-adhesion and aggregation.
Externí odkaz:
https://doaj.org/article/78b79e1b2b4e4736a8a8908c4e78773c
Autor:
Shinsuke Sando, Daisuke Kuroda, Shota Kudo, Sho Ito, Yutaro Saito, Kouhei Tsumoto, Akinobu Senoo, Kouhei Yoshida, Satoru Nagatoishi, Go Ueno, Takumi Tashima
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Many cadherin family proteins are associated with diseases such as cancer. Since cell adhesion requires homodimerization of cadherin molecules, a small-molecule regulator of dimerization would have therapeutic potential. Herein, we describe identific
Autor:
Yutaro Saito, Kouhei Yoshida, Shota Kudo, Takumi Tashima, Shinsuke Sando, Sho Ito, Go Ueno, Satoru Nagatoishi, Kouhei Tsumoto, Akinobu Senoo
Many cadherin family proteins are associated with diseases such as cancer. Since cell adhesion requires homodimerization of cadherin molecules, a small-molecule regulator of dimerization would have therapeutic potential. Herein, we describe identific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cebde37612319b56c5e0bcb7cb37316
https://doi.org/10.1101/2020.08.30.274647
https://doi.org/10.1101/2020.08.30.274647
Autor:
Hiroko Iwanari, Aya Sugyo, Tatsuya Higashi, Osamu Kusano-Arai, Hiroki Akiba, Kentaro Fujiwara, Ming-Rong Zhang, Kotaro Nagatsu, Chika Kikuchi, Hitomi Sudo, Shota Kudo, Kouhei Tsumoto, Toshimitsu Momose, Takao Hamakubo, Atsushi B. Tsuji
Publikováno v:
Nuclear Medicine Communications.
Objective We previously reported In-labeled anti-cadherin17 (CDH17) IgG visualized CDH17-positive gastric cancer xenografts. Unfortunately, a long waiting time was required to obtain high-contrast images due to long blood retention (blood half-life:
Autor:
Anna Yui, Masashi Fukayama, Hiroko Iwanari, Kouhei Tsumoto, Shota Kudo, Hiroki Akiba, Osamu Kusano-Arai, Takao Hamakubo, Keisuke Matsusaka, Chika Kikuchi, Atsushi Kaneda
Publikováno v:
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37:1-11
Cadherin-17 (CDH17) is highly expressed in gastric cancer and is thus considered to be a good target for antibody therapy. CDH17 is classified as a nonclassical cadherin, in that it is composed of seven extracellular cadherin domains. We generated an
Publikováno v:
Structure. 24:1523-1536
Orderly assembly of classical cadherins governs cell adhesion and tissue maintenance. A key event is the strand-swap dimerization of the extracellular ectodomains of two cadherin molecules from apposing cells. Here we have determined crystal structur
Autor:
Tomoya Mitani, Kouhei Tsumoto, Akinobu Senoo, Anna Moberg, Linnea N. Babol, Takumi Tashima, Shota Kudo, Satoru Nagatoishi
Publikováno v:
Chemical communications (Cambridge, England). 54(42)
The inhibitor for the homophilic dimerization of P-cadherin was discovered by SPR-based screening using fragment compounds. Our SPR assays identified a specific P-cadherin binder, which was able to inhibit the cell adhesion of living CHO cells that e
Publikováno v:
Journal of biochemistry. 162(4)
Artificial affinity maturation of antibodies is promising but often shows difficulties because the roles of each amino acid residue are not well known. To elucidate their roles in affinity against the antigen and thermal stability, interface residues