Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shoshona S, Le"'
Autor:
Anastasia S, Lambrou, Philip, Shirk, Molly K, Steele, Prabasaj, Paul, Clinton R, Paden, Betsy, Cadwell, Heather E, Reese, Yutaka, Aoki, Norman, Hassell, Xiao-Yu, Zheng, Sarah, Talarico, Jessica C, Chen, M Steven, Oberste, Dhwani, Batra, Laura K, McMullan, Alison Laufer, Halpin, Summer E, Galloway, Duncan R, MacCannell, Rebecca, Kondor, John, Barnes, Adam, MacNeil, Benjamin J, Silk, Vivien G, Dugan, Heather M, Scobie, David E, Wentworth, Jason, Caravas, Nicholas A, Kovacs, Jonathan G, Gerhart, Han, Jia Ng, Andrew, Beck, Reina, Chau, Roxana, Cintron, Peter W, Cook, Christopher A, Gulvik, Dakota, Howard, Yunho, Jang, Kristen, Knipe, Kristine A, Lacek, Kara A, Moser, Adrian C, Paskey, Benjamin L, Rambo-Martin, Roopa R, Nagilla, Adam C, Retchless, Matthew W, Schmerer, Sandra, Seby, Samuel S, Shepard, Richard A, Stanton, Thomas J, Stark, Anna, Uehara, Yvette, Unoarumhi, Meghan L, Bentz, Alex, Burgin, Mark, Burroughs, Morgan L, Davis, Matthew W, Keller, Lisa M, Keong, Shoshona S, Le, Justin S, Lee, Joseph C, Madden Jr, Sarah, Nobles, D. Collins, Owuor, Jasmine, Padilla, Mili, Sheth, Malania M, Wilson
Publikováno v:
MMWR. Morbidity and mortality weekly report. 71(6)
Genomic surveillance is a critical tool for tracking emerging variants of SARS-CoV-2 (the virus that causes COVID-19), which can exhibit characteristics that potentially affect public health and clinical interventions, including increased transmissib
Autor:
Kenneth L. Tyler, Ron J. Bouchard, Holger Barth, Kim A. Heidenreich, Reid A. Phelps, F. Alexandra Loucks, Daniel A. Linseman, Hiroshi Udo, Shoshona S. Le, Eric R. Kandel, Klaus Aktories, Sarah M. Richardson-Burns
Publikováno v:
Journal of Neurochemistry. 94:1025-1039
Rho GTPases are key transducers of integrin/extracellular matrix and growth factor signaling. Although integrin-mediated adhesion and trophic support suppress neuronal apoptosis, the role of Rho GTPases in neuronal survival is unclear. Here, we have
Autor:
Daniel A. Linseman, Ron J. Bouchard, Reid A. Phelps, Thomas A Precht, Brent D. Butts, Shoshona S. Le, Maria L. Florez-McClure, Tracey A. Laessig, Kim A. Heidenreich
Publikováno v:
The Journal of Neuroscience. 24:9993-10002
Glycogen synthase kinase-3β (GSK-3β) is a critical activator of neuronal apoptosis induced by a diverse array of neurotoxic insults. However, the downstream substrates of GSK-3β that ultimately induce neuronal death are unknown. Here, we show that
Publikováno v:
Hormone and Metabolic Research. 35:763-770
Cultured rat cerebellar granule neurons (CGNs) require depolarization-mediated calcium influx for survival. Calcium regulates the activity of the pro-survival transcription factor, myocyte enhancer factor 2D (MEF2D). MEF2D is hyperphosphorylated and
Autor:
Daniel A. Linseman, Brandon J. Cornejo, Ron J. Bouchard, Tracey A. Laessig, Mary Kay Meintzer, Shoshona S. Le, Kim A. Heidenreich
Publikováno v:
Journal of Neurochemistry. 85:1488-1499
Depolarization promotes the survival of cerebellar granule neurons via activation of the transcription factor myocyte enhancer factor 2D (MEF2D). Removal of depolarization induces hyperphosphorylation of MEF2D on serine/threonine residues, resulting
Autor:
Ron J. Bouchard, Brent D. Butts, Kim A. Heidenreich, Shoshona S. Le, Maria L. Florez-McClure, Daniel A. Linseman, F. Alexandra Loucks, Angela K. Zimmermann
Publikováno v:
Journal of neurochemistry. 94(1)
Primary cerebellar granule neurons (CGNs) require depolarizing extracellular potassium for their survival. Removal of depolarizing potassium triggers CGN apoptosis that requires induction of Bim, a BH3-only Bcl-2 family member. Bim is classically tho
Autor:
Kim A. Heidenreich, T A Precht, Shoshona S. Le, Ron J. Bouchard, Daniel A. Linseman, Tracey A. Laessig, Brent D. Butts, Reid A. Phelps
Publikováno v:
Cell death and differentiation. 12(3)
Cerebellar granule neurons (CGNs) require depolarization for their survival in culture. When deprived of this stimulus, CGNs die via an intrinsic apoptotic cascade involving Bim induction, Bax translocation, cytochrome c release, and caspase-9 and -3
Autor:
K.R. Ryan, Brent D. Butts, Daniel A. Linseman, Ron J. Bouchard, Kim A. Heidenreich, Shoshona S. Le, H.R. Hudson
Publikováno v:
Molecular and cellular neurosciences. 30(2)
The role of the proteasome in neuronal apoptosis is poorly understood since both anti- and pro-apoptotic effects result from proteasome inhibition. We studied the effects of proteasome inhibition in cultured rat cerebellar granule neurons. Acute expo
Autor:
Daniel A. Linseman, Kim A. Heidenreich, Shoshona S. Le, Charleen T. Chu, Ron J. Bouchard, Maria L. Florez-McClure, Tracey A. Laessig, Phil A. Barker
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(19)
The cellular mechanisms underlying Purkinje neuron death in various neurodegenerative disorders of the cerebellum are poorly understood. Here we investigate anin vitromodel of cerebellar neuronal death. We report that cerebellar Purkinje neurons, dep
Autor:
Ron J. Bouchard, Tracey A. Laessig, Mingtao Li, Christopher M. Bartley, Kim A. Heidenreich, Daniel A. Linseman, Shoshona S. Le, Mary Kay Meintzer
Publikováno v:
The Journal of biological chemistry. 278(42)
Cerebellar granule neuron (CGN) survival depends on activity of the myocyte enhancer factor-2 (MEF2) transcription factors. Neuronal MEF2 activity is regulated by depolarization via a mechanism that is presently unclear. Here, we show that depolariza