Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Shoshin Yoshida"'
Autor:
Kenshi Kamei, Mitsu Onoma, Hiroyasu Muramatsu, Osamu Kuromaru, Shoshin Yoshida, Theo L. Peeters, Hirokazu Sudo, Osamu Cynshi, Kenji Yogo, Hisanori Takanashi, Ken-ichi Ozaki
Publikováno v:
European Journal of Pharmacology. 581:296-305
The pharmacological properties of MA-2029, a novel motilin receptor antagonist, were investigated. In vitro , MA-2029 (1 to 30 nM) competitively inhibited motilin-induced contractions in isolated rabbit duodenal longitudinal muscle strips, with a pA
Autor:
Shoshin Yoshida, Kiyohiko Sugano, Masayuki Haramura, Hidetoshi Ushio, Mikio Takaku, Ryoichi Saitoh, Yoshiaki Nabuchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1939-1942
The intestinal permeability of benzamidine analogue thrombin inhibitor is correlated with molecular volume, lipophilicity (calculated log P and IAM column capacity factor), hydrogen bond acidity/basicity and dipolarity.
Publikováno v:
Bulletin of the Chemical Society of Japan. 64:1588-1593
The relationship between the temperature-sensitivity of the release of an entrapped drug from liposome as well as the type of drug or liposome is discussed. The drug release from DPPC liposome (dipalmitoylphosphatidylcholine liposome) has been confir
In vitro and in vivo studies of AT-1362, a newly synthesized and orally active inhibitor of thrombin
Autor:
Hyoung sik Seo, Takashi Dan, Chi ho Yun, Hak yeop Kim, Jaehyung Cho, Shoshin Yoshida, Bon am Koo, Takaki Koga
Publikováno v:
Thrombosis research. 100(1)
AT-1362 was found to be a potent, selective, and competitive inhibitor of thrombin, with a Ki value of 6.7 nM. In a rat model of venous thrombosis induced by partial stasis and endothelial disruption, the ID(50) values (a dose required to obtain 50%
Autor:
Shoshin Yoshida, Kiyohiko Sugano, Mikio Takaku, Ryoichi Saitoh, Yoshiaki Nabuchi, Masayuki Haramura, Hidetoshi Ushio
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1097