Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Shoshanna N. Zucker"'
Autor:
Matthew Yehl, Dominik Kucharski, Michelle Eubank, Brandon Gulledge, Gamal Rayan, Md Gias Uddin, Genevieve Remmers, Eugene S. Kandel, Douglas P. DuFaux, Timothy C. Hutcherson, Sandra Sexton, Shoshanna N. Zucker
Publikováno v:
Cells, Vol 12, Iss 16, p 2113 (2023)
Although melanoma accounts for only 5.3% of skin cancer, it results in >75% of skin-cancer-related deaths. To avoid disfiguring surgeries on the head and neck associated with surgical excision, there is a clear unmet need for other strategies to sele
Externí odkaz:
https://doaj.org/article/a1aa0862401c438788210c8dbf3158fb
Autor:
Joseph A. Wawrzyniak, Anna Bianchi-Smiraglia, Wiam Bshara, Sudha Mannava, Jeff Ackroyd, Archis Bagati, Angela R. Omilian, Michael Im, Natalia Fedtsova, Jeffrey C. Miecznikowski, Kalyana C. Moparthy, Shoshanna N. Zucker, Qianqian Zhu, Nadezhda I. Kozlova, Albert E. Berman, Keith S. Hoek, Andrei V. Gudkov, Donna S. Shewach, Carl D. Morrison, Mikhail A. Nikiforov
Publikováno v:
Cell Reports, Vol 5, Iss 2, Pp 493-507 (2013)
Melanoma is one of the most aggressive types of human cancers, and the mechanisms underlying melanoma invasive phenotype are not completely understood. Here, we report that expression of guanosine monophosphate reductase (GMPR), an enzyme involved in
Externí odkaz:
https://doaj.org/article/778f0726387c4d02b68bac1250ad63c9
Autor:
Matthew Yehl, Dominik Kucharski, Michelle Eubank, Xavier Ramadan, Ahmad Dianat, Bianca Pham, Timothy C. Hutcherson, Sandra Sexton, Shoshanna N. Zucker
Publikováno v:
Cancer Research. 83:4780-4780
A novel preclinical experimental therapy for various cancer types including melanoma is the combination of nonthermal plasma (NTP) and tirapazamine (TPZ) delivered in situ. This patented combination therapy delivers reactive oxygen species (ROS) and
Autor:
Matthew Yehl, Andrew Nicolais, Samuel Gerardi, Ahmad Dianat, Olivia Kucharski, Timothy C. Hutcherson, Shoshanna N. Zucker
Publikováno v:
Cancer Research. 82:1053-1053
Considering the side effects common to most chemotherapeutic agents, a novel approach was developed to selectively treat cancer by targeting the oxidative stress pathway which is induced in many tumor types. Our previous studies demonstrated that non
Publikováno v:
IEEE Transactions on Dielectrics and Electrical Insulation. 24:2241-2247
Nonthermal plasma has shown promising results as a treatment method for melanoma cancer cells. To generate the high voltage AC signal required to ionize helium, a resonance transformer is used. This work compares two circuits, a manual tuning circuit
Autor:
Shoshanna N. Zucker, Hossein Dianat, Joseph Pechette, Yesul Song, Andrew Nicolais, Zethan Koch, Timothy C. Hutcherson, J.L. Zirnheld, Cory Higley, Kyle Thompson, Peter Casey, Elana Chazen, Jay Shah, Archis Bagati, Lisa Chiu, Mikhail A. Nikiforov
Publikováno v:
Cancer Research. 80:B32-B32
We have developed a novel approach for treating melanoma by selectively targeting cancer cells with reactive oxygen species (ROS). This combination therapy incorporates ROS generated by 1) nonthermal plasma (NTP) that emits a multitude of ROS and 2)
Autor:
C E Foley, Song Liu, Katerina I. Leonova, Melissa J. Grimm, Paul N. Bogner, Shoshanna N. Zucker, Emily E. Fink, Kalyana Moparthy, Archis Bagati, Sandra Sexton, Joseph A. Wawrzyniak, Eugene S. Kandel, Yurij Ionov, Andrei V. Bakin, Jianmin Wang, Brahm H. Segal, Mikhail A. Nikiforov, Sudha Mannava, Anna Bianchi-Smiraglia, Yuesheng Zhang, Naftali Kaminski
Publikováno v:
Molecular Cell. 53(6):916-928
Reactive oxygen species (ROS) activate NF-E2-related transcription factor 2 (Nrf2), a key transcriptional regulator driving antioxidant gene expression and protection from oxidant injury. Here we report that in response to elevation of intracellular
Autor:
Ronald Berezney, Tara A. Bancroft, Benjamin Des Soye, David E. Place, Archis Bagati, Shoshanna N. Zucker
Publikováno v:
Journal of Cellular Physiology. 228:853-859
Previous reports have implicated connexin 43 (Cx43) as a tumor suppressor in early stages of tumorigenesis and in some cases as an enhancer of cell migration in later stages. To address the role of Cx43 in melanoma tumor progression, we utilized two
Publikováno v:
2016 IEEE International Power Modulator and High Voltage Conference (IPMHVC).
Nonthermal plasma has shown promising results as a treatment method for melanoma cancer cells. However, the implementation of nonthermal plasma for melanoma cancer cell therapy is hindered by the need for precise setup and constant manual reconfigura
Autor:
Srikanth R, Polusani, Edward A, Kalmykov, Anjana, Chandrasekhar, Shoshanna N, Zucker, Bruce J, Nicholson
Publikováno v:
Journal of cell science. 129(23)
Gap junction proteins (connexins) have crucial effects on cell motility in many systems, from migration of neural crest cells to promotion of metastatic invasiveness. Here, we show that expression of Cx26 (also known as GJB2) in HeLa cells specifical