Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Shoshana Yakar"'
Autor:
Sher Bahadur Poudel, Ryan R. Ruff, Gozde Yildirim, Richard A. Miller, David E. Harrison, Randy Strong, Thorsten Kirsch, Shoshana Yakar
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is a major contributing factor to OA, and as one ages, various joint tissues undergo gradual c
Externí odkaz:
https://doaj.org/article/d256ca38541c4e61b75a42aa0e812485
Publikováno v:
Bone Reports, Vol 15, Iss , Pp 101108- (2021)
There is no cure for osteogenesis imperfecta (OI), and current treatments can only partially correct the bone phenotype. Stem cell therapy holds potential to improve bone quality and quantity in OI. Here, we conduct a systematic review and meta-analy
Externí odkaz:
https://doaj.org/article/f980e369bd884b8ba9d2cb069f1d0e59
Autor:
Laris Achlaug, Lina Somri-Gannam, Shilhav Meisel-Sharon, Rive Sarfstein, Manisha Dixit, Shoshana Yakar, Mordechai Hallak, Zvi Laron, Haim Werner, Ilan Bruchim
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
The insulin-like growth factors (IGF) are important players in the development of gynecological malignancies, including epithelial ovarian cancer (EOC). The identification of biomarkers that can help in the diagnosis and scoring of EOC patients is of
Externí odkaz:
https://doaj.org/article/1afbe2b029f3461694ba8b14108ce8cf
Autor:
Manisha Dixit, Zhongbo Liu, Sher Bahadur Poudel, Gozde Yildirim, Yanjiao Zhang Zhang, Shilpa Mehta, Omer Murik, Geona Altarescu, Yoshifumi Kobayashi, Emi Shimizu, Mitchell B. Schaffler, Shoshana Yakar
Publikováno v:
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
ABSTRACT Patients with type 1 diabetes mellitus (T1DM) exhibit reduced BMD and significant increases in fracture risk. Changes in BMD are attributed to blunted osteoblast activity and inhibited bone remodeling, but these cannot fully explain the impa
Externí odkaz:
https://doaj.org/article/c5cdf96ce96e4b9a81953f785af6e4aa
Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism
Autor:
Mukundan Attur, Cuijie Lu, Xiaodong Zhang, Tianzhen Han, Cassidy Alexandre, Cristina Valacca, Shuai Zheng, Sarina Meikle, Branka Brukner Dabovic, Evelyne Tassone, Qing Yang, Victoria Kolupaeva, Shoshana Yakar, Steven Abramson, Paolo Mignatti
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101789- (2020)
Summary: Membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14), a transmembrane proteinase with a short cytoplasmic tail, is a major effector of extracellular matrix remodeling. Genetic silencing of MT1-MMP in mouse (Mmp14−/−) and man causes
Externí odkaz:
https://doaj.org/article/c75bb8befb1a45eeb5542b86036af6fd
Autor:
Vicente Barrios, Julie A. Chowen, Álvaro Martín-Rivada, Santiago Guerra-Cantera, Jesús Pozo, Shoshana Yakar, Ron G. Rosenfeld, Luis A. Pérez-Jurado, Juan Suárez, Jesús Argente
Publikováno v:
Cells, Vol 10, Iss 12, p 3576 (2021)
The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles during development, maturation, and aging. Members of this axis, composed of various ligands, receptors, and binding proteins, are regulated in a tissue- and time-s
Externí odkaz:
https://doaj.org/article/7137f6b70c424230a9041cc9a0718ec4
Autor:
Manisha Dixit, Leeann D Louis, Jelena Basta‐Pljakic, Gozde Yildirim, Sher‐Bahadur Poudel, Fancy Kumararaja, Edward O List, Silvana Ortiz Duran, John J Kopchick, Ryan R Ruff, Mitchell B Schaffler, Shoshana Yakar
Publikováno v:
Journal of Bone and Mineral Research. 37:2201-2214
Excess in growth hormone (GH) levels, seen in patients with acromegaly, is associated with increases in fractures. This happens despite wider bones and independent of bone mineral density. We used the bovine GH (bGH) transgenic mice, which show const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955895b236900b51d4e5c174af8ce682
https://doi.org/10.1002/jbmr.4699
https://doi.org/10.1002/jbmr.4699
Autor:
Rand Shibel, Rive Sarfstein, Karthik Nagaraj, Lena Lapkina-Gendler, Zvi Laron, Manisha Dixit, Shoshana Yakar, Haim Werner
Publikováno v:
Cells, Vol 10, Iss 6, p 1483 (2021)
Endometrial cancer is the most common gynecologic malignancy in Western countries. The insulin-like growth factor-1 (IGF1) axis has an important role in endometrial cancer biology and emerged as a promising therapeutic target in oncology. However, th
Externí odkaz:
https://doaj.org/article/3d5acbacd8e84b5ebeb88f5e8d8ed1f4
Autor:
Gozde Yildirim, Edmara T. P. Bergamo, Sher Bahadur Poudel, Ryan R. Ruff, Manisha Dixit, Bin Hu, Dindo Q. Mijares, Lukasz Witek, Carolyn Chlebek, David E. Harrison, Randy Strong, Richard A. Miller, Warren Ladiges, Timothy G. Bromage, Clifford J. Rosen, Shoshana Yakar
Publikováno v:
GeroScience.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4408faf88b9d7fa36c8318227aba7aa0
https://doi.org/10.1007/s11357-023-00803-8
https://doi.org/10.1007/s11357-023-00803-8
Autor:
Shoshana Yakar, Chand Khanna, Sung-Hyeok Hong, Arnulfo Mendoza, Xiaoli Chen, Nomeli Nunez, Ruslan Novosyadlyy, Wilson Mejia, Hui Sun, Pnina Brodt, Yingjie Wu
Supplementary Figure 4C-D from Insulin-Like Growth Factor-I Regulates the Liver Microenvironment in Obese Mice and Promotes Liver Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8113b3f06f7d3f6a9c25472f12ac12c5
https://doi.org/10.1158/0008-5472.22383225.v1
https://doi.org/10.1158/0008-5472.22383225.v1
