Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shoshana Sedley"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8083 (2024)
Cancer cells depend on specific oncogenic pathways or present a genetic alteration that leads to a particular disturbance. Still, personalized and targeted biological therapy remains challenging, with current efforts generally yielding disappointing
Externí odkaz:
https://doaj.org/article/41a198f733d84bc1bc6958313d0455d3
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8758 (2022)
G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and disease functions, yet knowledge of their role in colon cancer stem cell maintenance is still lacking. In addition, the molecular mechanisms underlying GPCR-induced
Externí odkaz:
https://doaj.org/article/10ac2f44372c4530ab7a781a6c214dfc
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8985 (2021)
The essential role of G-protein coupled receptors (GPCRs) in tumor growth is recognized, yet a GPCR based drug in cancer is rare. Understanding the molecular path of a tumor driver gene may lead to the design and development of an effective drug. For
Externí odkaz:
https://doaj.org/article/ab83031ca614437da2db010a61e4f79d
Autor:
Jeetendra Kumar Nag, Hodaya Malka, Shoshana Sedley, Priyanga Appasamy, Tatyana Rudina, Tgst Levi, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit
Publikováno v:
Molecular Cancer Therapeutics. 21:1415-1429
While the role of G-protein–coupled receptors (GPCR) in cancer is acknowledged, their underlying signaling pathways are understudied. Protease-activated receptors (PAR), a subgroup of GPCRs, form a family of four members (PAR1–4) centrally involv
Supplementary Figure from PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
Autor:
Rachel Bar-Shavit, Beatrice Uziely, Chaim Gilon, Amnon Hoffman, Tgst Levi, Tatyana Rudina, Priyanga Appasamy, Shoshana Sedley, Hodaya Malka, Jeetendra Kumar Nag
Supplementary Figure from PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0453d20132cce1787e1084d5606b5234
https://doi.org/10.1158/1535-7163.22523497
https://doi.org/10.1158/1535-7163.22523497
Autor:
Rachel Bar-Shavit, Beatrice Uziely, Chaim Gilon, Amnon Hoffman, Tgst Levi, Tatyana Rudina, Priyanga Appasamy, Shoshana Sedley, Hodaya Malka, Jeetendra Kumar Nag
Supplementary Table from PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a76f2d36747c9732a6e06237440834b
https://doi.org/10.1158/1535-7163.22523494
https://doi.org/10.1158/1535-7163.22523494
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8985, p 8985 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The essential role of G-protein coupled receptors (GPCRs) in tumor growth is recognized, yet a GPCR based drug in cancer is rare. Understanding the molecular path of a tumor driver gene may lead to the design and development of an effective drug. For