Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Shoshana Loya"'
Autor:
Felix Hoppe-Seyler, Assaf Friedler, Abraham Loyter, Shoshana Loya, Ayelet Armon-Omer, Karin Butz, Aviad Levin, Amnon Hizi, Zvi Hayouka
Publikováno v:
Journal of Molecular Biology. 376:971-982
The human immunodeficiency virus type 1 (HIV-1) integrase (IN) protein is an emerging target for the development of anti-HIV drugs. We recently described a new approach for inhibiting IN by "shiftides"--peptides that inhibit the protein by shifting i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd641ddf83d2f3d212509b41554dd74
https://doi.org/10.1016/j.jmb.2007.11.095
https://doi.org/10.1016/j.jmb.2007.11.095
Autor:
Joseph Rosenbluh, Elena Britan, Moshe Kotler, Zvi Hayouka, Amnon Hizi, Aviad Levin, Ayelet Armon-Omer, Assaf Friedler, Abraham Loyter, Shoshana Loya
Publikováno v:
Journal of Biological Chemistry. 282:15743-15753
Human immunodeficiency virus 1 (HIV-1) Rev and integrase (IN) proteins are required within the nuclei of infected cells in the late and early phases of the viral replication cycle, respectively. Here we show using various biochemical methods, that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2a109cd55f3646eafec715b96eabfe
https://doi.org/10.1074/jbc.m609864200
https://doi.org/10.1074/jbc.m609864200
Publikováno v:
Nucleic Acids Research. 31:1481-1487
Reverse transcriptases (RTs) exhibit DNA polymerase and ribonuclease H (RNase H) activities. The RTs of human immunodeficiency viruses type 1 and type 2 (HIV-1 and HIV-2) are composed of two subunits, both sharing the same N-terminus (which encompass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffbeaa2831b7cda4edd3a39883a58b2
https://doi.org/10.1093/nar/gkg235
https://doi.org/10.1093/nar/gkg235
Publikováno v:
Virology. 307:341-357
The study of porcine endogenous retroviruses (PERVs) becomes increasingly important due to the potential use of pig cells, tissues, and organs as a source for xenogenic cell therapy and xenotransplantation into humans. Consequently, we have construct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b33019595313b3237fa502eed59e830
https://doi.org/10.1016/s0042-6822(02)00131-9
https://doi.org/10.1016/s0042-6822(02)00131-9
Publikováno v:
Biochemical Journal. 362:685-692
Polyacetylenetriol (PAT), a natural marine product from the Mediterranean sea sponge Petrosia sp., was found to be a novel general potent inhibitor of DNA polymerases. It inhibits equally well the RNA- and DNA-dependent DNA polymerase activities of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2361bd66add6de0c6a7933a2aa9dbc3c
https://doi.org/10.1042/bj3620685
https://doi.org/10.1042/bj3620685
Publikováno v:
Journal of Molecular Biology. 311:957-971
Retroviral reverse transcriptases (RTs) have both DNA polymerase and ribonuclease H (RNase H) activities. The RTs of HIV-1 and HIV-2 are heterodimers of p66/p51 and p68/p54 subunits, respectively. The smaller subunit lacks the C-terminal segment of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5445c42860ebae0dfe89390810576643
https://doi.org/10.1006/jmbi.2001.4904
https://doi.org/10.1006/jmbi.2001.4904
Autor:
Shoshana Loya, Patrick J. Murphy, Amnon Hizi, Andrew Howard-Jones, Simon J. Coles, Gregory P. Black, Christopher G. Moore, Michael B. Hursthouse, Walshe Nigel Derek Arthur, Nigel K. Smith, Alan T McGown
Publikováno v:
Tetrahedron Letters. 42:3377-3381
Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f66d981a90a31b63245dedee8f9052db
https://doi.org/10.1016/s0040-4039(01)00400-2
https://doi.org/10.1016/s0040-4039(01)00400-2
Publikováno v:
European Journal of Organic Chemistry. 2000:729-735
The structure of the known secondary metabolite β-rubromycin was corrected, based on spectroscopic and chemical investigations, from o-quinone 1 to p-quinone 6. By feeding [U-13C3]malonic acid to the rubromycin-producing strain, Streptomyces sp. A1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f18dc28327cef0fb600d45f7c5192ce
https://doi.org/10.1002/(sici)1099-0690(200003)2000:5<729::aid-ejoc729>3.0.co
https://doi.org/10.1002/(sici)1099-0690(200003)2000:5<729::aid-ejoc729>3.0.co
Publikováno v:
Biochemical Journal. 344:85-92
Polycitone A, an aromatic alkaloid isolated from the ascidian Polycitorsp. exhibits potent inhibitory capacity of both RNA- and DNA-directed DNA polymerases. The drug inhibits retroviral reverse transcriptase (RT) [i.e. of human immunodeficiency viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39e77c37102f004aca3bd829b7bbfa1
https://doi.org/10.1042/bj3440085
https://doi.org/10.1042/bj3440085
Autor:
Shoshana Loya, Shmuel Carmeli, Erez Mizrachi, and Amnon Hizi, Tal Maretzki, Vered Reshef, Colin Silberstein
Publikováno v:
Journal of Natural Products. 60:1251-1260
Five novel diacylated sulfoglycolipids (1-5) were isolated from the cyanobacterium Scytonema sp. (TAU strain SL-30-1-4) and four novel acylated diglycolipids (6-9) were isolated from the cyanobacterium Oscillatoria raoi (TAU strain IL-76-1-2). These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b8c9534ed03078b18aa012999fd9e5
https://doi.org/10.1021/np970327m
https://doi.org/10.1021/np970327m