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Publikováno v:
Asian Journal of Organic Chemistry. 10:2486-2502
Publikováno v:
Organic letters. 22(21)
The chiral synthesis of (+)-saxitoxin and its derivatives is described. Two consecutive carbon-nitrogen bonds at C-5 and C-6 in saxitoxin were effectively installed by the sequential Overman rearrangement of an allylic vicinal diol derived from d-mal