Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Shondra M. Pruett-Miller"'
Autor:
Priya Mittal, Jacquelyn A. Myers, Raymond D. Carter, Sandi Radko-Juettner, Hayden A. Malone, Wojciech Rosikiewicz, Alexis N. Robertson, Zhexin Zhu, Ishwarya V. Narayanan, Baranda S. Hansen, Meadow Parrish, Natarajan V. Bhanu, Robert J. Mobley, Jerold E. Rehg, Beisi Xu, Yiannis Drosos, Shondra M. Pruett-Miller, Mats Ljungman, Benjamin A. Garcia, Gang Wu, Janet F. Partridge, Charles W. M. Roberts
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in nearly 25% of cancers. To gain insight into the mechanisms by which SWI/SNF mutations drive cancer, we contributed ten rhabdoid tumor (RT) cell lines muta
Externí odkaz:
https://doaj.org/article/fb1fbd9e73e346ad922fc3783cc2f771
Autor:
Ratnakar R. Bynigeri, R. K. Subbarao Malireddi, Raghvendra Mall, Jon P. Connelly, Shondra M. Pruett-Miller, Thirumala-Devi Kanneganti
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background The innate immune system serves as the first line of host defense. Transforming growth factor-β–activated kinase 1 (TAK1) is a key regulator of innate immunity, cell survival, and cellular homeostasis. Because of its importance
Externí odkaz:
https://doaj.org/article/6c8aa98cb49f4dbe90bd184bed5e3736
Autor:
Kashi Raj Bhattarai, Robert J. Mobley, Kelly R. Barnett, Daniel C. Ferguson, Baranda S. Hansen, Jonathan D. Diedrich, Brennan P. Bergeron, Satoshi Yoshimura, Wenjian Yang, Kristine R. Crews, Christopher S. Manring, Elias Jabbour, Elisabeth Paietta, Mark R. Litzow, Steven M. Kornblau, Wendy Stock, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Cheng Cheng, Shondra M. Pruett-Miller, Mary V. Relling, Jun J. Yang, William E. Evans, Daniel Savic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Defining genetic factors impacting chemotherapy failure can help to better predict response and identify drug resistance mechanisms. However, there is limited understanding of the contribution of inherited noncoding genetic variation on inte
Externí odkaz:
https://doaj.org/article/50de02b6348449e7a1264f8dc70d8016
Autor:
Mary H. Patton, Kristen T. Thomas, Ildar T. Bayazitov, Kyle D. Newman, Nathaniel B. Kurtz, Camenzind G. Robinson, Cody A. Ramirez, Alexandra J. Trevisan, Jay B. Bikoff, Samuel T. Peters, Shondra M. Pruett-Miller, Yanbo Jiang, Andrew B. Schild, Anjana Nityanandam, Stanislav S. Zakharenko
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114503- (2024)
Summary: Synaptic plasticities, such as long-term potentiation (LTP) and depression (LTD), tune synaptic efficacy and are essential for learning and memory. Current studies of synaptic plasticity in humans are limited by a lack of adequate human mode
Externí odkaz:
https://doaj.org/article/0879bdaf39594d3bb0c97326e7c2bfec
Autor:
Joo-Hui Han, Rajendra Karki, R. K. Subbarao Malireddi, Raghvendra Mall, Roman Sarkar, Bhesh Raj Sharma, Jonathon Klein, Harmut Berns, Harshan Pisharath, Shondra M. Pruett-Miller, Sung-Jin Bae, Thirumala-Devi Kanneganti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Innate immunity provides the first line of defense through multiple mechanisms, including pyrogen production and cell death. While elevated body temperature during infection is beneficial to clear pathogens, heat stress (HS) can lead to infl
Externí odkaz:
https://doaj.org/article/1f8e57b9c0414514b61fbb0f7ff9fd17
Autor:
Majd Khiami, Yan Ju, Lei Han, Jonathan Klein, Min-Joon Han, Shondra M. Pruett-Miller, Marcin W. Wlodarski
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103532- (2024)
Induced pluripotent stem cells (iPSCs) harboring patient derived SAMD9 mutation offer a unique platform to study the multi-organ involvement observed in this rare disease, referred to as myelodysplasia, infections, restriction of growth, adrenal hypo
Externí odkaz:
https://doaj.org/article/0c12dce7c9574b02bd12643e74df49a5
Autor:
Gisele Nishiguchi, Lauren G. Mascibroda, Sarah M. Young, Elizabeth A. Caine, Sherif Abdelhamed, Jeffrey J. Kooijman, Darcie J. Miller, Sourav Das, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan M. Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Shilpa Narina, Melvin Thomas, Allister J. Loughran, Ravi Kalathur, Kaiwen Yu, Suiping Zhou, Xusheng Wang, Anthony A. High, Junmin Peng, Shondra M. Pruett-Miller, Danette L. Daniels, Marjeta Urh, Anang A. Shelat, Charles G. Mullighan, Kristin M. Riching, Guido J. R. Zaman, Marcus Fischer, Jeffery M. Klco, Zoran Rankovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Molecular-glue degraders are small molecules that induce a specific interaction between an E3 ligase and a target protein, resulting in the target proteolysis. The discovery of molecular glue degraders currently relies mostly on screening ap
Externí odkaz:
https://doaj.org/article/93a742dfa7284effac1e877a18d0d84e
Autor:
Michelle Maurin, Mohammadreza Ranjouri, Cristina Megino-Luque, Justin Y. Newberg, Dongliang Du, Katelyn Martin, Robert E. Miner, Mollie S. Prater, Dave Keng Boon Wee, Barbara Centeno, Shondra M. Pruett-Miller, Paul Stewart, Jason B. Fleming, Xiaoqing Yu, Jose Javier Bravo-Cordero, Ernesto Guccione, Michael A. Black, Karen M. Mann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract RNA splicing is an important biological process associated with cancer initiation and progression. However, the contribution of alternative splicing to pancreatic cancer (PDAC) development is not well understood. Here, we identify an enrichm
Externí odkaz:
https://doaj.org/article/0792cf6371164a1eae6f885ff6f53bed
Autor:
Madeline B. Searcy, Randolph K. Larsen, Bradley T. Stevens, Yang Zhang, Hongjian Jin, Catherine J. Drummond, Casey G. Langdon, Katherine E. Gadek, Kyna Vuong, Kristin B. Reed, Matthew R. Garcia, Beisi Xu, Darden W. Kimbrough, Grace E. Adkins, Nadhir Djekidel, Shaina N. Porter, Patrick A. Schreiner, Shondra M. Pruett-Miller, Brian J. Abraham, Jerold E. Rehg, Mark E. Hatley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) driven by the expression of the PAX3-FOXO1 (P3F) fusion oncoprotein is an aggressive subtype of pediatric rhabdomyosarcoma. FP-RMS histologically resembles developing muscle yet occurs throughout the
Externí odkaz:
https://doaj.org/article/af11c11b372b412d83edd57dfaac71cf
Autor:
Hyeong-Min Lee, William C. Wright, Min Pan, Jonathan Low, Duane Currier, Jie Fang, Shivendra Singh, Stephanie Nance, Ian Delahunty, Yuna Kim, Richard H. Chapple, Yinwen Zhang, Xueying Liu, Jacob A. Steele, Jun Qi, Shondra M. Pruett-Miller, John Easton, Taosheng Chen, Jun Yang, Adam D. Durbin, Paul Geeleher
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Combination chemotherapy is crucial for successfully treating cancer. However, the enormous number of possible drug combinations means discovering safe and effective combinations remains a significant challenge. To improve this process, we c
Externí odkaz:
https://doaj.org/article/8ea60511d9b646e7b01a18ad97adfba0