Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Shonagh Russell"'
Autor:
Pamela N. Peters, Regina S. Whitaker, Felicia Lim, Shonagh Russell, Elizabeth A. Bloom, Justin Pollara, Kyle C. Strickland, Mark J. Cantwell, Amer Beg, Andrew Berchuck, Scott Antonia, Rebecca A. Previs
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101056- (2024)
Single agent immune checkpoint inhibitors have been ineffective for patients with advanced stage and recurrent high grade serous ovarian cancer (HGSOC). Using pre-clinical models of HGSOC, we evaluated the anti-tumor and immune stimulatory effects of
Externí odkaz:
https://doaj.org/article/6671225534084b968c89f7e95e76d5ae
Autor:
Shonagh Russell, Liping Xu, Yoonseok Kam, Dominique Abrahams, Bryce Ordway, Alex S. Lopez, Marilyn M. Bui, Joseph Johnson, Tamir Epstein, Epifanio Ruiz, Mark C. Lloyd, Pawel Swietach, Daniel Verduzco, Jonathan Wojtkowiak, Robert J. Gillies
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-20 (2022)
Abstract Introduction Aggressive cancers commonly ferment glucose to lactic acid at high rates, even in the presence of oxygen. This is known as aerobic glycolysis, or the “Warburg Effect.” It is widely assumed that this is a consequence of the u
Externí odkaz:
https://doaj.org/article/c08b6bd921534c2bac3f3262ad7ecba1
Autor:
Alexandra N. Aquino-Acevedo, Hope Knochenhauer, Yesenia Castillo-Ocampo, Melanie Ortiz-León, Yadiel A. Rivera-López, Camily Morales-López, Melanie E. Cruz-Robles, Elvin R. Hernández-Cordero, Shonagh Russell, Regina Whitaker, Margarita Bonilla-Claudio, Dung-Tsa Chen, Julie Dutil, Stephanie L. Gaillard, John S. Yi, Rebecca A. Previs, Guillermo N. Armaiz-Pena
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 26, Iss , Pp 100558- (2022)
Mounting evidence suggests that chronic stress and subsequent distress can promote ovarian cancer progression. These altered psychological states have been linked to sustained release of stress hormones, activation of the β-adrenergic receptors in o
Externí odkaz:
https://doaj.org/article/3eb607b6969c40b0a65c7270ae4d5d1a
Autor:
Hao Wu, Veronica Estrella, Matthew Beatty, Dominique Abrahams, Asmaa El-Kenawi, Shonagh Russell, Arig Ibrahim-Hashim, Dario Livio Longo, Yana K. Reshetnyak, Anna Moshnikova, Oleg A. Andreev, Kimberly Luddy, Mehdi Damaghi, Krithika Kodumudi, Smitha R. Pillai, Pedro Enriquez-Navas, Shari Pilon-Thomas, Pawel Swietach, Robert J. Gillies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
T-cell activation primarily occurs in the lymph nodes, highly organized and specialized secondary lymphoid organs. Here the authors show that the acidic extracellular pH in lymph node paracortical zones limits cytokine production by effector T-cells,
Externí odkaz:
https://doaj.org/article/8a725d35fbca44839f00a263e2a935bc
Autor:
Robert A. Gatenby, Robert J. Gillies, Alexander R.A. Anderson, Joel S. Brown, Marilyn M. Bui, Mark C. Lloyd, Kam Yoonseok, Shonagh Russell, Jonathan W. Wojtkowiak, Yoganand Balagurunathan, Mehdi Damaghi, Pedro M. Enriquez-Navas, Mark Robertson-Tessi, Arig Ibrahim-Hashim
Ongoing intratumoral evolution is apparent in molecular variations among cancer cells from different regions of the same tumor, but genetic data alone provide little insight into environmental selection forces and cellular phenotypic adaptations that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b349c40659fe01e66d9e538ca5181b0
https://doi.org/10.1158/0008-5472.c.6510057
https://doi.org/10.1158/0008-5472.c.6510057
Autor:
Robert A. Gatenby, Robert J. Gillies, Alexander R.A. Anderson, Joel S. Brown, Marilyn M. Bui, Mark C. Lloyd, Kam Yoonseok, Shonagh Russell, Jonathan W. Wojtkowiak, Yoganand Balagurunathan, Mehdi Damaghi, Pedro M. Enriquez-Navas, Mark Robertson-Tessi, Arig Ibrahim-Hashim
Simultaneous video of four simulations of tumor growth with accompanying phenotypic "flow" diagram, Top left: untreated; top right: low dose, early; bottom left: high dose, late; bottom right: low dose, late. The appearance of the white box in each o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f448ee4f0ea507d017699912426172b
https://doi.org/10.1158/0008-5472.22418178
https://doi.org/10.1158/0008-5472.22418178
Autor:
Robert J. Gillies, Arig Ibrahim-Hashim, James J. Mulé, Jonathan W. Wojtkowiak, Mehdi Damaghi, Kimberly Luddy, Amy M. Weber, Shonagh Russell, Asmaa E. El-Kenawi, Krithika N. Kodumudi, Shari Pilon-Thomas
Cancer immunotherapies, such as immune checkpoint blockade or adoptive T-cell transfer, can lead to durable responses in the clinic, but response rates remain low due to undefined suppression mechanisms. Solid tumors are characterized by a highly aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5688543a11a663550d998bca4f5c7110
https://doi.org/10.1158/0008-5472.c.6507795
https://doi.org/10.1158/0008-5472.c.6507795
Autor:
Robert J. Gillies, Arig Ibrahim-Hashim, James J. Mulé, Jonathan W. Wojtkowiak, Mehdi Damaghi, Kimberly Luddy, Amy M. Weber, Shonagh Russell, Asmaa E. El-Kenawi, Krithika N. Kodumudi, Shari Pilon-Thomas
Supplemental Figure S1: Inhibition of PI3 kinase signaling leads to loss of T cell function. Activated T cells were cultured at pH 6.6 or 7.4 for 24h in presence or absence of the PI3K Supplemental Figure S2: OT-1 T cell metabolism. OT-1 T cells were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a909f5b747f5783e8dac9d8fb9b21d0
https://doi.org/10.1158/0008-5472.22409493.v1
https://doi.org/10.1158/0008-5472.22409493.v1
Autor:
Robert J. Gillies, Arig Ibrahim-Hashim, James J. Mulé, Jonathan W. Wojtkowiak, Mehdi Damaghi, Kimberly Luddy, Amy M. Weber, Shonagh Russell, Asmaa E. El-Kenawi, Krithika N. Kodumudi, Shari Pilon-Thomas
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd086b4139c2191bacbf9e41100b9cc5
https://doi.org/10.1158/0008-5472.22409496.v1
https://doi.org/10.1158/0008-5472.22409496.v1
Autor:
Pamela Peters, Regina Whitaker, Felicia Lim, Shonagh Russell, Justin Pollara, Elizabeth Bloom, Kyle Strickland, Mark Cantwell, Amer Beg, Andrew Berchuck, Scott Antonia, Rebecca Previs
Publikováno v:
Featured Printed Posters (Poster Rounds with the Professors).