Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shona Morrison"'
Autor:
Briana Spolding, Timothy Connor, Carrie Wittmer, Lelia L F Abreu, Antony Kaspi, Mark Ziemann, Gunveen Kaur, Adrian Cooper, Shona Morrison, Scott Lee, Andrew Sinclair, Yann Gibert, James L Trevaskis, Jonathon D Roth, Assam El-Osta, Richard Standish, Ken Walder
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92656 (2014)
BACKGROUND AND AIMS: A major impediment to establishing new treatments for non-alcoholic steatohepatitis is the lack of suitable animal models that accurately mimic the biochemical and metabolic characteristics of the disease. The aim of this study w
Externí odkaz:
https://doaj.org/article/13a67a5e3d2a4746890cfefb42e46c36
Autor:
Susan Richter, Shona Morrison, Tim Connor, Jiechuang Su, Cristin G Print, Ron S Ronimus, Sean L McGee, William R Wilson
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65267 (2013)
Zinc finger nucleases (ZFN) are powerful tools for editing genes in cells. Here we use ZFNs to interrogate the biological function of ADPGK, which encodes an ADP-dependent glucokinase (ADPGK), in human tumour cell lines. The hypothesis we tested is t
Externí odkaz:
https://doaj.org/article/8d9f47e8f7a54fb29b238330a1aa7612
Autor:
Kirsten F. Howlett, Shona Morrison, Timothy Connor, Brian G. Drew, Amanda J Genders, Peter J. Meikle, Simon T. Bond, Sean L. McGee
Publikováno v:
The Journal of endocrinology. 246(3)
Protein kinase D (PKD) is emerging as an important kinase regulating energy balance and glucose metabolism; however, whether hepatic PKD activity can be targeted to regulate these processes is currently unclear. In this study, hepatic PKD activity wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569696c53271e2e94f50f57363d70250
https://pubmed.ncbi.nlm.nih.gov/32698129
https://pubmed.ncbi.nlm.nih.gov/32698129
Publikováno v:
Australian and New Zealand Journal of Obstetrics and Gynaecology. 57:458-463
Background Gestational trophoblastic neoplasia (GTN) is classified as a highly curable group of pregnancy-related malignancies; however, approximately 15% will be persistent and require chemotherapy. Up to 25% of these women will develop resistance a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164acd933b5e6030e50dd1845315550a
https://doi.org/10.1111/ajo.12622
https://doi.org/10.1111/ajo.12622
Autor:
Mark A. Febbraio, Gregory R. Steinberg, Kylie Venardos, Kathryn Aston-Mourney, Roelof van Ewijk, Timothy Connor, Stefan M. Gehrig, Mark Hargreaves, Courtney Swinton, Ken Walder, Gordon S. Lynch, Darren C. Henstridge, Sean L. McGee, Shona Morrison, Sheree D. Martin, Vidhi Gaur
Publikováno v:
Diabetes, Obesity and Metabolism. 19:936-943
Aims/Hypothesis Current drugs used to treat metabolic diseases such as obesity and type 2 diabetes have limited efficacy in directly normalising muscle insulin action, while exercise is effective in enhancing this aspect of metabolic disease. We rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e43dab5b6dc8e4eda337c14b34d9137
https://doi.org/10.1111/dom.12896
https://doi.org/10.1111/dom.12896
Autor:
Vidhi, Gaur, Timothy, Connor, Kylie, Venardos, Darren C, Henstridge, Sheree D, Martin, Courtney, Swinton, Shona, Morrison, Kathryn, Aston-Mourney, Stefan M, Gehrig, Roelof, van Ewijk, Gordon S, Lynch, Mark A, Febbraio, Gregory R, Steinberg, Mark, Hargreaves, Ken R, Walder, Sean L, McGee
Publikováno v:
Diabetes, obesitymetabolism. 19(7)
To determine the effect of Scriptaid, a compound that can replicate aspects of the exercise adaptive response through disruption of the class IIa histone deacetylase (HDAC) corepressor complex, on muscle insulin action in obesity.Diet-induced obese m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::257d9cc9fa6cc3050e07109953017b90
https://pubmed.ncbi.nlm.nih.gov/28155245
https://pubmed.ncbi.nlm.nih.gov/28155245
Autor:
Juan Carlos Molero, Victoria C. Foletta, Nicky Konstantopoulos, Stephen Wanyonyi, Adrian Cooper, Guy Y. Krippner, Timothy Connor, Briana Spolding, Courtney Swinton, Ken Walder, Sean L. McGee, Sofianos Andrikopoulos, Sharon Jones, R. Fahey, Shona Morrison, Melissa de Vries, Lucía García-Guerra
Publikováno v:
Diabetes
We previously used Gene Expression Signature technology to identify methazolamide (MTZ) and related compounds with insulin sensitizing activity in vitro. The effects of these compounds were investigated in diabetic db/db mice, insulin-resistant diet-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3c99a4b41759527d27bfa64be54e0b
https://doi.org/10.2337/db11-0578
https://doi.org/10.2337/db11-0578
Publikováno v:
Cellular Physiology and Biochemistry. 28:157-162
Zinc accumulation may impair cellular bioenergetics, which is associated with neuronal apoptosis. We simultaneously assessed anaerobic and aerobic metabolism in live cells to characterise this effect and hypothesised that the omega 3 fatty acid docos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6870f739405e43fef91e84778ff15e87
https://doi.org/10.1159/000331724
https://doi.org/10.1159/000331724
Autor:
Ken Walder, Sean L. McGee, Yann Gibert, Daniel Fraher, Shona Morrison, Megan K. Ellis, Alister C. Ward
Publikováno v:
Endocrinology. 156(10)
The endocannabinoid system (ECS) and retinoic acid (RA) signaling have been associated with influencing lipid metabolism. We hypothesized that modulation of these pathways could modify lipid abundance in developing vertebrates and that these pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd66daadd70ce0c7caa979cb392510f0
https://pubmed.ncbi.nlm.nih.gov/26181105
https://pubmed.ncbi.nlm.nih.gov/26181105
Autor:
Shona Morrison, Sean L. McGee
Publikováno v:
Adipocyte. 4(4)
Differentiated 3T3-L1 adipocytes are a widely used in vitro model of white adipocytes. In addition to classical white and brown adipocytes that are derived from different cell lineages, beige adipocytes have also been identified, which have character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d34dd6e73479fd62329950b9f28819d
https://pubmed.ncbi.nlm.nih.gov/26451286
https://pubmed.ncbi.nlm.nih.gov/26451286