Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Shomir Ghosh"'
Autor:
Corey Fyfe, Gabriella Fiorentino, Michael J. Steinbaugh, Joana Campos, Hannah Lawson, Jozef Durko, Donal O'Carroll, Kamil Kranc, Darren Harvey, Shomir Ghosh, Robert M. Campbell
Publikováno v:
Cancer Research. 83:447-447
The terminal uridyltransferases TUT4/7 (ZCCHC11/6) are important mediators of RNA stability, RNA decay, histone mRNA regulation, viral RNA sensing, and miRNA biogenesis. Regulation of RNA processing pathways can be mediated by a number of RNA-binding
Autor:
Corey Fyfe, Gabriella Fiorentino, Michael Steinbaugh, Joana Campos, Hannah Lawson, Jozef Durko, Dónal O'Carroll, Kamil Kranc, Darren Harvey, Shomir Ghosh, Robert M Campbell
Publikováno v:
Blood. 140:12994-12994
Autor:
Robinson Triboulet, Khikmet Sadykov, Jessica L. Johnson, Andrew R. Snyder, Sarah K. Knutson, Pavan Kumar, Christopher B. Mayo, Dillon Hawley, Andrew Madanjian, Ross L. Stein, David M. Wilson, Darren M. Harvey, Shomir Ghosh, Robert M. Campbell
Publikováno v:
Cancer Research. 82:1822-1822
The purpose of the study was to determine if genetic and pharmacological inhibition of terminal uridyltransferases (TUTases) ZCCHC11 and ZCCHC6 could modulate Glioblastoma (GBM) cell growth in vitro. ZCCHC11 (also known as TUT4 and TENT3A) and ZCCHC6
Autor:
Scott B. Snapper, Shomir Ghosh, Diane Mathis, Christophe Benoist, Ray Jupp, Ashlee M. Earl, Liza Konnikova, David Zemmour, Adriana Ortiz-Lopez, Dennis L. Kasper, Dalia Burzyn, Abigail Manson McGuire, Sungwhan F. Oh, Naama Geva-Zatorsky, Mercedes Lobera, Jianfei Yang, Esen Sefik
Publikováno v:
Science. 349:993-997
Gut microbes make T cells keep the peace Our guts harbor trillions of microbial inhabitants, some of which regulate the types of immune cells that are present in the gut. For instance, Clostridium species of bacteria induce a type of T cell that prom
Autor:
Lisa A. Orband-Miller, Erkan Baloglu, Jianfei Yang, Ashley A. Barnes, Jill Skepner, Thaddeus J. Carlson, Darby Schmidt, Mark S. Sundrud, Shomir Ghosh, Mercedes Lobera, Jonathan Hill, Radha Ramesh, Mohamed Boudjelal, Mark Trocha
Publikováno v:
The Journal of Immunology. 192:2564-2575
IL-17–producing CD4+Th17 cells, CD8+Tc17 cells, and γδ T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORγt is required for the differentiation of Th17 cells and expression of IL-17. In this article, we describe a novel
Autor:
Tracy J. Jenkins, Pia Cwarzko Rummel, Stefanie Thiele, Mette M. Rosenkilde, Lars Baumann, Hans R. Lüttichau, Roland Kolbeck, Kristine Niss Arfelt, Anders H. Johnsen, Shomir Ghosh, James E. Pease
Publikováno v:
British Journal of Pharmacology. 167:1206-1217
Background and purpose Here we present a novel series of CCR8 antagonists based on a naphthalene-sulfonamide structure. This structure differs from the predominant pharmacophore for most small-molecule CC-chemokine receptor antagonists, which in fact
Autor:
Mette M. Rosenkilde, Pia C. Jensen, Elder Amy M, Roland Kolbeck, Stefanie Thiele, Anne Steen, Shomir Ghosh, Thomas M. Frimurer
Publikováno v:
British Journal of Pharmacology. 166:258-275
BACKGROUND AND PURPOSE The majority of small molecule compounds targeting chemokine receptors share a similar pharmacophore with a centrally located aliphatic positive charge and flanking aromatic moieties. Here we describe a novel piperidine-based c
Autor:
Mingshi Dai, Swanee Jacutin-Porte, Wei Yin, Charles A. Minor, Shan Huang, Tracy J. Jenkins, Weirong Chen, Gang Li, Thomas E. Lightburn, Daniel Cardillo, Matthew Jones, Shomir Ghosh, Douglas F. Burdi, Christopher Blackburn, Robert Bennett, Roland Kolbeck, Sean Smith, B. Scott Freeze, Timothy D. Ocain, Geraldine C Harriman, Kenneth M. Gigstad, Bing Guan
Publikováno v:
Journal of Medicinal Chemistry. 50:566-584
The design, synthesis, and structure-activity relationship development of naphthalene-derived human CCR8 antagonists is described. In vitro binding assay results of these investigations are reported, critical interactions of the antagonists with CCR8
In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists
Autor:
Jill Skepner, Erkan Baloglu, Jonathan Hill, Mark Trocha, Mark S. Sundrud, Xiaoyan Qu, Michael A. Nolan, Radha Ramesh, Jianfei Yang, Scott Davis, Shomir Ghosh, Thaddeus J. Carlson, Darby Schmidt, Mercedes Lobera
Publikováno v:
Immunology. 145(3)
The orphan nuclear receptor, retinoic acid receptor-related orphan nuclear receptor γt (RORγt), is required for the development and pathogenic function of interleukin-17A-secreting CD4(+) T helper type 17 (Th17) cells. Whereas small molecule RORγt
Autor:
Peter B. Rahl, Jinsong Wang, Yonghui Wang, Chuan Wu, Xichen Lin, Mark S. Sundrud, Sheng Xiao, Mercedes Lobera, Zhong Zhong, Jianfei Yang, Alexander Marson, Karsten Kretschmer, Yan Xu, Pei-Yun Tsai, Aviv Regev, Radha Ramesh, Erkan Baloglu, Shomir Ghosh, David A. Hafler, Chen Zhu, Zhijun Xiang, Richard A. Young, Ling Zhou, Vijay K. Kuchroo, Darby Schmidt, Nir Yosef
Publikováno v:
Immunity, vol 40, iss 4
PMC
PMC
We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including Th17-cell-mediated autoimmune disease. We systemically characterized RORγt binding in the presence a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62b927ac7d62181e49ec164d7ead0e1
https://europepmc.org/articles/PMC4066874/
https://europepmc.org/articles/PMC4066874/