Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sholto De Wet"'
Autor:
Erin Buchanan, Caitlyn Mahony, Sophia Bam, Mohamed Jaffer, Sarah Macleod, Asandile Mangali, Mignon van der Watt, Sholto de Wet, Rensu Theart, Caron Jacobs, Ben Loos, Colleen O’Ryan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Propionic acid (PPA) is used to study the role of mitochondrial dysfunction in neurodevelopmental conditions like autism spectrum disorders. PPA is known to disrupt mitochondrial biogenesis, metabolism, and turnover. However, the effect of P
Externí odkaz:
https://doaj.org/article/ea405245f5cb4ff49942b613f24a7e03
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Neurodegenerative diseases are often characterized by hydrophobic inclusion bodies, and it may be the case that the aggregate-prone proteins that comprise these inclusion bodies are in fact the cause of neurotoxicity. Indeed, the appearance of protei
Externí odkaz:
https://doaj.org/article/31435a9593784a0f876dd09b3d7703b9
The Highs and Lows of Memantine—An Autophagy and Mitophagy Inducing Agent That Protects Mitochondria
Autor:
Sholto de Wet, Asandile Mangali, Richard Batt, Jurgen Kriel, Nicola Vahrmeijer, Dana Niehaus, Rensu Theart, Ben Loos
Publikováno v:
Cells, Vol 12, Iss 13, p 1726 (2023)
Memantine is an FDA-approved, non-competitive NMDA-receptor antagonist that has been shown to have mitochondrial protective effects, improve cell viability and enhance clearance of Aβ42 peptide. Currently, there are uncertainties regarding the preci
Externí odkaz:
https://doaj.org/article/864be34d55e64b88950057bf1cd68c7a
Publikováno v:
Cells, Vol 10, Iss 1, p 95 (2021)
Autophagy flux is the rate at which cytoplasmic components are degraded through the entire autophagy pathway and is often measured by monitoring the clearance rate of autophagosomes. The specific means by which autophagy targets specific cargo has re
Externí odkaz:
https://doaj.org/article/0aaf87abddcd404e97acc1d8f1e3b048
Publikováno v:
Cells, Vol 7, Iss 8, p 94 (2018)
Autophagy failure is implicated in age-related human disease. A decrease in the rate of protein degradation through the entire autophagy pathway, i.e., autophagic flux, has been associated with the onset of cellular proteotoxity and cell death. Altho
Externí odkaz:
https://doaj.org/article/3bb8e627e0d74c63a1acbab790afa276
Publikováno v:
Biogerontology. 24:149-162
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eafef428200919714b45dcdf2d954eff
https://doi.org/10.1007/s10522-022-10012-z
https://doi.org/10.1007/s10522-022-10012-z
The Highs and Lows of Memantine—An Autophagy and Mitophagy Inducing Agent That Protects Mitochondria
Autor:
Loos, Sholto de Wet, Asandile Mangali, Richard Batt, Jurgen Kriel, Nicola Vahrmeijer, Dana Niehaus, Rensu Theart, Ben
Publikováno v:
Cells; Volume 12; Issue 13; Pages: 1726
Memantine is an FDA-approved, non-competitive NMDA-receptor antagonist that has been shown to have mitochondrial protective effects, improve cell viability and enhance clearance of Aβ42 peptide. Currently, there are uncertainties regarding the preci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::9284e446ad5fd96f0c3498069d82e4c8
Autor:
Gabriella L. Robertson, Stellan Riffle, Mira Patel, Caroline Bodnya, Andrea Marshall, Heather K. Beasley, Edgar Garza-Lopez, Jianqiang Shao, Zer Vue, Antentor Hinton, Maria S. Stoll, Sholto de Wet, Rensu P. Theart, Ram Prosad Chakrabarty, Ben Loos, Navdeep S. Chandel, Jason A. Mears, Vivian Gama
Publikováno v:
Journal of Cell Science. 136
Mitochondria and peroxisomes are dynamic signaling organelles that constantly undergo fission, driven by the large GTPase dynamin-related protein 1 (DRP1; encoded by DNM1L). Patients with de novo heterozygous missense mutations in DNM1L present with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d8b0ab7b0e6268ac69e48b33dae4e3a
https://doi.org/10.1242/jcs.260370
https://doi.org/10.1242/jcs.260370
Autor:
Gabriella L. Robertson, Stellan Riffle, Mira Patel, Andrea Marshall, Heather Beasley, Edgar Garza Lopez, Jianqiang Shao, Zer Vue, Maria S. Stoll, Sholto de Wet, Rensu P. Theart, Ben Loos, Antentor Hinton, Jason A. Mears, Vivian Gama
Mitochondria and peroxisomes are both dynamic signaling organelles that constantly undergo fission. While mitochondrial fission is known to coordinate cellular metabolism, proliferation, and apoptosis, the physiological relevance of peroxisome dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6f69be0c8bc178ab0722c9bf247c111
https://doi.org/10.1101/2021.12.31.474637
https://doi.org/10.1101/2021.12.31.474637
Autor:
Quentin Willot, Andre du Toit, Sholto de Wet, Elizabeth J. Huisamen, Ben Loos, John S. Terblanche
Mechanisms aimed at recovering from heat-induced damage are closely associated with the ability of ectotherms to survive exposition to stressful temperatures. Among these mechanisms the respective contribution of autophagy, a ubiquitous stress-respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66693e36db5a996a40e2a38dfca7e432
https://doi.org/10.1101/2021.12.09.471892
https://doi.org/10.1101/2021.12.09.471892