Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Shoko Itakura"'
Autor:
Lanwen Gao, Fansu Meng, Zhenjiang Yang, Markel Lafuente-Merchan, Laura Merino Fernández, Ye Cao, Kosuke Kusamori, Makiya Nishikawa, Shoko Itakura, Junqian Chen, Xiaoxun Huang, Dongfang Ouyang, Oliver Riester, Hans-Peter Deigner, Haibiao Lai, Jose Luis Pedraz, Murugan Ramalingam, Yu Cai
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117327- (2024)
Breast cancer (BC) is one of the most frequently diagnosed cancers in women. Chemotherapy continues to be the treatment of choice for clinically combating it. Nevertheless, the chemotherapy process is frequently hindered by multidrug resistance, ther
Externí odkaz:
https://doaj.org/article/008a899297f843d39eced9e1dabd7dfe
Autor:
Daisuke Sasaki, Hinako Suzuki, Kosuke Kusamori, Shoko Itakura, Hiroaki Todo, Makiya Nishikawa
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Rice bran a by-product of the rice milling process is currently underutilized. Recent studies have shown that plant-derived nanoparticles (pdNPs) can be mass-produced at a low cost and exhibit biological and therapeutic activities
Externí odkaz:
https://doaj.org/article/9c1cb045dab54284b2a343c35537cc2a
Autor:
Yuya Yoshida, Manami Aoki, Kalin Nagase, Koichi Marubashi, Hiroyuki Kojima, Shoko Itakura, Syuuhei Komatsu, Kenji Sugibayashi, Hiroaki Todo
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1219 (2024)
Objectives: Non-viral mediated plasmid DNA transfection by electroporation (EP) is an established method for gene transfection. In this study, the usefulness of direct EP at an intradermal (i.d.) site (DEP) with implanted electrodes to achieve a high
Externí odkaz:
https://doaj.org/article/6f448a52ba904334a8026b0bfefa916f
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background Mesenchymal stem/stromal cells (MSCs) have been used in clinical trials for various diseases. These have certain notable functions such as homing to inflammation sites, tissue repair, and immune regulation. In many pre-clinical st
Externí odkaz:
https://doaj.org/article/f85166ed1723468d80fce71248e38517
Autor:
Hiroaki Todo, Rina Niki, Akie Okada, Ibuki Narita, Kazuya Inamura, Ayu Ito, Shoko Itakura, Ichiro Hijikuro, Kenji Sugibayashi
Publikováno v:
Frontiers in Drug Delivery, Vol 3 (2023)
Non-lamellar liquid crystal (NLLC) structures have gained increasing attention for the controlled release of entrapped drugs. In the present study, an in situ NLLC structure-forming depot formulation through contact with water was developed using a t
Externí odkaz:
https://doaj.org/article/c9c6b2ca48e54baf8776b7e15015be95
Autor:
Shoko Itakura, Ayaka Shohji, Sayaka Amagai, Masashi Kitamura, Kozo Takayama, Kenji Sugibayashi, Hiroaki Todo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Small interfering RNAs (siRNAs) knockdown the expression of target genes by causing mRNA degradation and are a promising therapeutic modality. In clinical practice, lipid nanoparticles (LNPs) are used to deliver RNAs, such as siRNA and mRNA,
Externí odkaz:
https://doaj.org/article/f96df1de8724498eadfc95c6b189c627
Publikováno v:
AAPS Open, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract Purpose Nobiletin (NOB), a polymethoxyflavonoid, is known for its antioxidant and anti-inflammatory effects and has antitumor activity. However, its poor solubility and low bioavailability pose a significant challenge in its delivery. In thi
Externí odkaz:
https://doaj.org/article/220498e22fa74a67a6811dc55d0faf84
Autor:
Ayu Ito, Shoko Itakura, Yuya Hasegawa, Miyu Hashimoto, Akie Okada, Mamoru Hirafuji, Hidenori Nakamura, Kenji Sugibayashi, Hiroaki Todo
Publikováno v:
Frontiers in Drug Delivery, Vol 3 (2023)
Patients receiving chemotherapy by intravenous (i.v.) or oral administration of anticancer drugs often experience side effects. In this study, an electro-osmotic flow (EO) pump was used for the direct administration of an anticancer drug with minimum
Externí odkaz:
https://doaj.org/article/4bb2d619a61945f5bc998ac069e0bd7b
Autor:
Daisuke Sasaki, Kosuke Kusamori, Yukiya Takayama, Shoko Itakura, Hiroaki Todo, Makiya Nishikawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Recent studies showed that plant-derived nanoparticles (NPs) can be easily produced in high yields and have potential applications as therapeutic agents or delivery carriers for bioactive molecules. In this study, we selected corn as it is i
Externí odkaz:
https://doaj.org/article/3ad506f4c34b4dada91c8ee949aefc8f
Autor:
Etsuko Miyamoto-Sato, Satoshi Imanishi, Lijuan Huang, Shoko Itakura, Yoichi Iwasaki, Masamichi Ishizaka
Publikováno v:
Molecules, Vol 28, Iss 14, p 5600 (2023)
“Undruggable” targets such as KRAS are particularly challenging in the development of drugs. We devised a novel chemical knockdown strategy, CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) technology, which promotes protein deg
Externí odkaz:
https://doaj.org/article/c5fc44b190e545cb960106366a050147