Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Shoki Okuda"'
Publikováno v:
BMC Psychiatry, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Background There is limited consensus regarding the optimal treatment of insomnia. The recent introduction of orexin receptor antagonists (ORA) has increased the available treatment options. However, the prescribing patterns of hypnotics in
Externí odkaz:
https://doaj.org/article/9d5d27f85ae94736a51f1f60b1a0c31e
Publikováno v:
Drugs - Real World Outcomes, Vol 10, Iss 2, Pp 271-281 (2023)
Abstract Background Few studies have examined the prescribing patterns of orexin receptor antagonists (ORAs) in the real-world clinical setting in Japan. Objective We sought to analyze the factors associated with ORA prescriptions for patients with i
Externí odkaz:
https://doaj.org/article/8bb339cb7da24df89304fd2b92e7ed8a
Autor:
Shigeru Tokita, Kotoba Okuyama, Yasuyuki Okumura, Naoya Ueda, Masakazu Igarashi, Hideki Sano, Kanae Takahashi, Zaina P Qureshi, Asao Ogawa, Shoki Okuda
Publikováno v:
BMJ Open, Vol 12, Iss 12 (2022)
Objectives Delirium is a neuropsychiatric disorder that commonly occurs in elderly patients with cognitive impairment. The economic burden of delirium in Japan has not been well characterised. In this study, we assessed incremental medical costs of d
Externí odkaz:
https://doaj.org/article/8965ea65e0434a209bdda80304fe8e80
Autor:
Shigeru Tokita, Kotoba Okuyama, Yasuyuki Okumura, Naoya Ueda, Masakazu Igarashi, Hideki Sano, Kanae Takahashi, Zaina P Qureshi, Asao Ogawa, Shoki Okuda
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Objectives Delirium commonly occurs during hospitalisation and is associated with increased mortality, especially in elderly patients. This study aimed to determine the demographic and clinical characteristics of patients with delirium in the Japanes
Externí odkaz:
https://doaj.org/article/7d0f634279c14afda7a56028d9539454
Autor:
Naoya Ueda, Masakazu Igarashi, Kotoba Okuyama, Hideki Sano, Kanae Takahashi, Zaina P Qureshi, Shigeru Tokita, Asao Ogawa, Yasuyuki Okumura, Shoki Okuda
Publikováno v:
BMJ open. 12(9)
ObjectivesDelirium commonly occurs during hospitalisation and is associated with increased mortality, especially in elderly patients. This study aimed to determine the demographic and clinical characteristics of patients with delirium in the Japanese
Autor:
Masakazu Igarashi, Kotoba Okuyama, Naoya Ueda, Hideki Sano, Kanae Takahashi, Zaina P Qureshi, Shigeru Tokita, Asao Ogawa, Yasuyuki Okumura, Shoki Okuda
Publikováno v:
BMJ Open. 12:e062141
ObjectivesDelirium is a neuropsychiatric disorder that commonly occurs in elderly patients with cognitive impairment. The economic burden of delirium in Japan has not been well characterised. In this study, we assessed incremental medical costs of de
Publikováno v:
Sleep. 45:A198-A198
Introduction Optimal treatment of insomnia is uncommon, given the lack of awareness regarding insomnia management. While the treatment landscape for insomnia has evolved following the introduction of orexin receptor antagonists (ORA), few studies hav
Autor:
Shoki Okuda, Yasuyoshi Arikawa, Tomohiro Okawa, Junichi Sakamoto, Nobuyuki Amano, Shinobu Sasaki, Masanori Nakakariya, Yugo Habata, Shizuo Kasai, Natsu Hotta, Kenichi Hamagami, Masaaki Funata, Yasutaka Nagisa, Minoru Maruyama, Toshimi Nagi, Yasunori Nio
Publikováno v:
Endocrinology. 158:1298-1313
Bombesin receptor subtype 3 (BRS-3) is an orphan G protein-coupled receptor. Based on the obese phenotype of male BRS-3-deficient mice, BRS-3 has been considered an attractive target for obesity treatment. Here, we developed a selective BRS-3 agonist
Publikováno v:
Journal of Neurology
Background Sleep disturbance in Alzheimer’s disease (AD) patients may have a negative impact not only on patients themselves but also on the physical and mental health of their caregivers. Detailed analysis of these issues is lacking. Objective Thi
Autor:
Uttam Khamrai, Jumpei Aida, Mrinalkanti Kundu, Tsuneo Yasuma, Mikio Shirasaki, Shoki Okuda, Shizuo Kasai, Syunsuke Yamamoto, Asato Kina, Masashi Takahashi, Toshihiro Noguchi, Yasutaka Nagisa, Yayoi Kawata, Hideyuki Igawa, Minoru Ikoma, Yasushi Fujioka, Keiko Kakegawa, Tsuyoshi Maekawa, Masaharu Nakayama
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2486-2503
Melanin-concentrating hormone (MCH) is an attractive target for antiobesity agents, and numerous drug discovery programs are dedicated to finding small-molecule MCH receptor 1 (MCHR1) antagonists. We recently reported novel pyridine-2(1 H )-ones as a