Zobrazeno 1 - 10
of 474
pro vyhledávání: '"Shokat KM"'
Autor:
Lee, JK, Phillips, JW, Smith, BA, Park, JW, Stoyanova, T, McCaffrey, EF, Baertsch, R, Sokolov, A, Meyerowitz, JG, Mathis, C, Cheng, D, Stuart, JM, Shokat, KM, Gustafson, WC, Huang, J, Witte, ON
Publikováno v:
Cancer cell, vol 29, iss 4
Lee, JK; Phillips, JW; Smith, BA; Park, JW; Stoyanova, T; McCaffrey, EF; et al.(2016). N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell, 29(4), 536-547. doi: 10.1016/j.ccell.2016.03.001. UCSF: Retrieved from: http://www.escholarship.org/uc/item/8vx8f6w6
Lee, JK; Phillips, JW; Smith, BA; Park, JW; Stoyanova, T; McCaffrey, EF; et al.(2016). N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell, 29(4), 536-547. doi: 10.1016/j.ccell.2016.03.001. UCSF: Retrieved from: http://www.escholarship.org/uc/item/8vx8f6w6
© 2016 Elsevier Inc. MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and the cellular origin of NEPC have not been established. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::439ad50061f5662e641b2365db2424eb
https://escholarship.org/uc/item/8vx8f6w6
https://escholarship.org/uc/item/8vx8f6w6
Autor:
Krogan, Nevan, Shokat, Kevan, Lim, Wendell, Martin, H, Shales, M, Fernandez-Piñar, P, Wei, P, Molina, M, Fiedler, D, Shokat, KM, Beltrao, P, Krogan, NJ
Publikováno v:
Krogan, Nevan; Shokat, Kevan; Lim, Wendell; Martin, H; Shales, M; Fernandez-Piñar, P; et al.(2015). Differential genetic interactions of yeast stress response MAPK pathways. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4v13v08q
© 2015 The Authors.Abstract Genetic interaction screens have been applied with great success in several organisms to study gene function and the genetic architecture of the cell. However, most studies have been performed under optimal growth conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::91b734f66bfedf53965f8d8623f92068
http://www.escholarship.org/uc/item/4v13v08q
http://www.escholarship.org/uc/item/4v13v08q
Publikováno v:
Shokat, Kevan; Lazarus, MB; Novotny, CJ; & Shokat, KM. (2015). Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3268q4d8
© 2014 American Chemical Society.Autophagy is a conserved cellular process that involves the degradation of cellular components for energy maintenance and cytoplasmic quality control that has recently gained interest as a novel target for a variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::16b323e0ebe1a160adac0783f0a27c22
http://www.escholarship.org/uc/item/3268q4d8
http://www.escholarship.org/uc/item/3268q4d8
Autor:
Zikherman, Julie, Shokat, Kevan, Weiss, Arthur, Au-Yeung, BB, Melichar, HJ, Ross, JO, Cheng, DA, Shokat, KM, Robey, EA
Publikováno v:
Zikherman, Julie; Shokat, Kevan; Weiss, Arthur; Au-Yeung, BB; Melichar, HJ; Ross, JO; et al.(2014). Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/97x6826b
The catalytic activity of Zap70 is crucial for T cell antigen receptor (TCR) signaling, but the quantitative and temporal requirements for its function in thymocyte development are not known. Using a chemical-genetic system to selectively and reversi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::378e9e7d4db0c65e4057b63c78545f2f
http://www.escholarship.org/uc/item/97x6826b
http://www.escholarship.org/uc/item/97x6826b
Autor:
Warren, Robert, Shokat, Kevan, Atreya, CE, Sangale, Z, Xu, N, Matli, MR, Tikishvili, E, Welbourn, W, Stone, S, Shokat, KM, Warren, RS
Publikováno v:
Warren, Robert; Shokat, Kevan; Atreya, CE; Sangale, Z; Xu, N; Matli, MR; et al.(2013). PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/450342xx
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates the phosphoinositide-3-kinase (PI3K) signaling pathway. In colorectal cancer (CRC), observed frequencies of loss of PTEN expression, concordant expression in primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::a8a860e0fc2aa1eabb1529cbaffae5cc
http://www.escholarship.org/uc/item/450342xx
http://www.escholarship.org/uc/item/450342xx
Autor:
Shokat, Kevan, Larochelle, S, Amat, R, Glover-Cutter, K, Sansó, M, Zhang, C, Allen, JJ, Shokat, KM, Bentley, DL, Fisher, RP
Publikováno v:
Shokat, Kevan; Larochelle, S; Amat, R; Glover-Cutter, K; Sansó, M; Zhang, C; et al.(2012). Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6cb7772k
Promoter-proximal pausing by RNA polymerase II (Pol II) ensures gene-specific regulation and RNA quality control. Structural considerations suggested a requirement for initiation-factor eviction in elongation-factor engagement and pausing of transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::431ee7f54b23accc716beaf9c917489b
http://www.escholarship.org/uc/item/6cb7772k
http://www.escholarship.org/uc/item/6cb7772k
Autor:
Shokat, Kevan, Sansó, M, Lee, KM, Viladevall, L, Jacques, PE, Pagé, V, Nagy, S, Racine, A, St, CV, Zhang, C, Shokat, KM
Publikováno v:
Shokat, Kevan; Sansó, M; Lee, KM; Viladevall, L; Jacques, PE; Pagé, V; et al.(2012). A Positive Feedback Loop Links Opposing Functions of P-TEFb/Cdk9 and Histone H2B Ubiquitylation to Regulate Transcript Elongation in Fission Yeast. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/84v2g0pn
Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification. Whereas histone modifications have established roles in transcription initiation, their functions during elongation are not understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::994d9c8cc1c1a6187f19b30fb864a939
http://www.escholarship.org/uc/item/84v2g0pn
http://www.escholarship.org/uc/item/84v2g0pn
Autor:
Chen, C, Kudo, M, Rutaganira, F, Takano, H, Lee, C, Atakilit, A, Robinett, KS, Uede, T, Wolters, PJ, Shokat, KM, Huang, X, Sheppard, D
Publikováno v:
Chen, C; Kudo, M; Rutaganira, F; Takano, H; Lee, C; Atakilit, A; et al.(2012). Integrin α9β1in airway smooth muscle suppresses exaggerated airway narrowing. Journal of Clinical Investigation, 122(8), 2916-2927. doi: 10.1172/JCI60387. UCSF: Retrieved from: http://www.escholarship.org/uc/item/57k9b7gj
Exaggerated contraction of airway smooth muscle is the major cause of symptoms in asthma, but the mechanisms that prevent exaggerated contraction are incompletely understood. Here, we showed that integrin α9β1on airway smooth muscle localizes the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::df785b206ff70625595f38b0886def61
http://www.escholarship.org/uc/item/57k9b7gj
http://www.escholarship.org/uc/item/57k9b7gj
Autor:
Shokat, Kevan, Uhalte, E, Kirchner, M, Hellwig, N, Allen, JJ, Donat, S, Shokat, KM, Selbach, M, Abdelilah-Seyfried, S
Publikováno v:
Shokat, Kevan; Uhalte, E; Kirchner, M; Hellwig, N; Allen, JJ; Donat, S; et al.(2012). In vivo conditions to identify Prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2hh6734k
Protein kinase C iota is required for various cell biological processes including epithelial tissue polarity and organ morphogenesis. To gain mechanistic insight into different roles of this kinase, it is essential to identify specific substrate prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::3486ef026d9a63ed6344fddc06bd9ae7
http://www.escholarship.org/uc/item/2hh6734k
http://www.escholarship.org/uc/item/2hh6734k
Autor:
Shokat, Kevan, Sun, Y, Miao, Y, Yamane, Y, Zhang, C, Shokat, KM, Takematsu, H, Kozutsumi, Y, Drubin, DG
Publikováno v:
Shokat, Kevan; Sun, Y; Miao, Y; Yamane, Y; Zhang, C; Shokat, KM; et al.(2012). Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6g8748mb
Sphingoid intermediates accumulate in response to a variety of stresses, including heat, and trigger cellular responses. However, the mechanism by which stress affects sphingolipid biosynthesis has yet to be identified. Recent studies in yeast sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::f21a5a692436334759d08d149841470d
http://www.escholarship.org/uc/item/6g8748mb
http://www.escholarship.org/uc/item/6g8748mb