Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Shokaku Kim"'
Publikováno v:
Angewandte Chemie International Edition. 56:4011-4014
Azanucleosides, in which the 4'-oxygen atom has been replaced with a nitrogen atom, have drawn much attention owing to their anticancer and antivirus activity, and tolerance towards nucleases. However, the traditional synthetic strategy requires mult
Publikováno v:
Electrochimica Acta. 200:290-295
A facile electrochemical method for modification of the 5-position in N -acryloyl-proline methyl ester ( N -Acr-Pro-OMe), followed by post-functionalization at the N -terminus by conjugate addition, was developed using anodic modification in a LiClO
Publikováno v:
Organic Letters. 18:800-803
A straightforward method for the synthesis of oligonucleotide blocks using a Cbz-type alkyl-chain-soluble support (Z-ACSS) attached to the 3'-OH group of 3'-terminal nucleosides was developed. The Z-ACSS allowed for the preparation of fully protected
Publikováno v:
Organic Letters. 16:6404-6407
An efficient method for modifying a proline moiety through anodic carbon-carbon bond cleavage is developed. Use of the 2,4,6-trimethoxyphenyl (TMP) moiety as a leaving group at the 5-position allows the incorporation of various functional groups for
Publikováno v:
Tetrahedron. 69:2555-2559
Oxidative disulfide bond formations have been applied to soluble-tag-assisted method successfully to realize the total synthesis of α-conotoxin MII (4) that comprises 16 amino acid residues and possesses 2 disulfide bonds. Orthogonal peptide folding
Autor:
Yohei Okada, Hitoshi Abe, Takashi Nakae, Kazuo Nagano, Hideaki Suzuki, Nobuyoshi Ebata, Shokaku Kim, Toshihide Yamada, Kazuhiro Chiba, Shuji Fujita
Publikováno v:
The Journal of Organic Chemistry. 78:320-327
A soluble tag-assisted liquid-phase peptide synthesis was successfully established based on simple hydrophobic benzyl alcohols, which can be easily prepared from naturally abundant materials. Excellent precipitation yields can be obtained at each ste
Publikováno v:
Electrochimica Acta. 56:10626-10631
A fluorous micellar system in water has been created to produce a large interfacial area between these media that retains substrates, effectively facilitating intermolecular Diels–Alder reactions due to repulsion effects from both media. Because Li
Publikováno v:
Chemistry Letters. 43:1251-1253
Conjugated oligonucleotides attract interest from various areas such as medicine and nanotechnology. Common synthetic methods, however, rely on heterogeneous coupling strategies that often give low...
Autor:
Shokaku Kim, Kazuhiro Chiba
Publikováno v:
Electrochemistry. 77:21-29
Anodic processes in the lithium perchlorate/nitromethane (LPC/NM) electrolyte system provide a wide variety of carbon-carbon bond formation. The electrolyte solution exhibits markedly accelerated properties as a Lewis acid catalyst that even enable i
Publikováno v:
Tetrahedron. 64:2855-2863
In this paper, we describe a practical and efficient protocol for Sonogashira, Suzuki–Miyaura, and Mizoroki–Heck cross-coupling using a CBT system. The use of substrates with cycloalkane-soluble tags facilitates separation of the desired products