Výsledky vyhledávání - "Shok Ping Lim"

Challenges in qualification & management of raw materials in advanced therapy medicinal products

Publikováno v: Cell and Gene Therapy Insights. 8:269-277

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c4fdc1907182abf789bf04598306e99
https://doi.org/10.18609/cgti.2022.043

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Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Autor: Juan José Lozano, Linda Ariza-McNaughton, Jonathan M. Irish, Syed A Mian, Benedetta Costantini, Judith C. W. Marsh, Dominique Bonnet, Shahram Kordasti, Thanos P. Mourikis, Shok Ping Lim, Pilar Perez Abellan, Giovanni A M Povoleri, Ghulam J. Mufti, Susanne Heck, Giovanna Lombardi, Ander Abarrategi, Shreyans Gandhi, Marc Martinez Llordella, Rita Antunes Dos Reis

Publikováno v: Blood. 136:885-897

Idiopathic aplastic anemia (AA) has 2 key characteristics: an autoimmune response against hematopoietic stem/progenitor cells and regulatory T-cells (Tregs) deficiency. We have previously demonstrated reduction in a specific subpopulation of Treg in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55ae0d92bc89d6a0015a27e7bff1ccb
https://doi.org/10.1182/blood.2019001347

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miR-181c-BRK1 axis plays a key role in actin cytoskeleton-dependent T cell function

Autor: Alan G. Ramsay, David Darling, Nikolaos Ioannou, Shok Ping Lim, Ghulam J. Mufti, Joop Gaken

Publikováno v: Lim, S P, Ioannou, N, Ramsay, A G, Darling, D, Gäken, J & Mufti, G J 2018, ' miR-181c-BRK1 axis plays a key role in actin cytoskeleton-dependent T cell function ', Journal of Leukocyte Biology, vol. 103, no. 5, pp. 855-866 . https://doi.org/10.1002/JLB.1A0817-325RR

MicroRNAs are short endogenous noncoding RNAs that play pivotal roles in a diverse range of cellular processes. The miR-181 family is important in T cell development, proliferation, and activation. In this study, we have identified BRK1 as a potentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23391c7103b6d2075f012ab99e39374c
https://kclpure.kcl.ac.uk/ws/files/97275036/miR_181c_BRK1_axis_plays_LIM_Accepted15February2018_GREEN_AAM.pdf

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Mir-181c Modulates T Cell Function By Regulating the Expression of BRK1

Autor: Donal P. McLornan, David Darling, Shok Ping Lim, Alan G. Ramsay, Nikolaos Ioannou, Ghulam J. Mufti, Joop Gaken

Publikováno v: Blood. 128:132-132

Introduction MicroRNAs (miRNAs) are short endogenous non-coding RNAs consisting of 18-25 nucleotides in length which influence gene expression and play pivotal roles in a diverse range of cellular processes. Aberrant miRNA expression has been implica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8755e735f4f298083589e44a11bc65f5
https://doi.org/10.1182/blood.v128.22.132.132

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