Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Shoji Tajima"'
Autor:
Takamasa Ito, Musashi Kubiura-Ichimaru, Yuri Murakami, Aaron B. Bogutz, Louis Lefebvre, Isao Suetake, Shoji Tajima, Masako Tada
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
DNA methylation (DNAme; 5-methylcytosine, 5mC) plays an essential role in mammalian development, and the 5mC profile is regulated by a balance of opposing enzymatic activities: DNA methyltransferases (DNMTs) and Ten-eleven translocation dioxygenases
Externí odkaz:
https://doaj.org/article/99641d88b0f941718b248c99fdd478dc
Autor:
Norimasa Iwanami, Kohei Takeshita, Divine-Fondzenyuy Lawir, Isao Suetake, Shoji Tajima, Katarzyna Sikora, Inês Trancoso, Connor ÓMeara, Iliana Siamishi, Yousuke Takahama, Makoto Furutani-Seiki, Hisato Kondoh, Yasushige Yonezawa, Michael Schorpp, Thomas Boehm
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101260- (2020)
Summary: DNA methylation is a universal epigenetic mechanism involved in regulation of gene expression and genome stability. The DNA maintenance methylase DNMT1 ensures that DNA methylation patterns are faithfully transmitted to daughter cells during
Externí odkaz:
https://doaj.org/article/9dc9bcf901e54e3d837b33f1a672b111
A novel sensitive detection method for DNA methylation in circulating free DNA of pancreatic cancer.
Autor:
Keiko Shinjo, Kazuo Hara, Genta Nagae, Takayoshi Umeda, Keisuke Katsushima, Miho Suzuki, Yoshiteru Murofushi, Yuta Umezu, Ichiro Takeuchi, Satoru Takahashi, Yusuke Okuno, Keitaro Matsuo, Hidemi Ito, Shoji Tajima, Hiroyuki Aburatani, Kenji Yamao, Yutaka Kondo
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233782 (2020)
Despite recent advances in clinical treatment, pancreatic cancer remains a highly lethal malignancy. In order to improve the survival rate of patients with pancreatic cancer, the development of non-invasive diagnostic methods using effective biomarke
Externí odkaz:
https://doaj.org/article/9ce8a46c5a6c4cabb6c94b20f4c52693
Autor:
Georgia Rose Kafer, Xuan Li, Takuro Horii, Isao Suetake, Shoji Tajima, Izuho Hatada, Peter Mark Carlton
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1283-1292 (2016)
5-hydroxymethylcytosine (5hmC) is a DNA base created during active DNA demethylation by the recently discovered TET enzymes. 5hmC has essential roles in gene expression and differentiation. Here, we demonstrate that 5hmC also localizes to sites of DN
Externí odkaz:
https://doaj.org/article/86e8dff51c0c44bab7e73c018cad286c
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 741-747 (2015)
Hydroxymethylcytosine has been shown to be involved in DNA demethylation and gene expression. Although methods to determine the position of hydroxymethylcytosine at single‐base resolution have been reported, these methods involve some difficulties.
Externí odkaz:
https://doaj.org/article/66a837b87db94d06a3a745bc1471f256
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14647-14658 (2013)
Members of the microRNA-29 (miR-29) family directly target the DNA methyltransferases, DNMT3A and DNMT3B. Disturbances in the expression levels of miR-29 have been linked to tumorigenesis and tumor aggressiveness. Members of the miR-29 family are cur
Externí odkaz:
https://doaj.org/article/0958232bb398410f9180e890abdbe06a
Autor:
Takahiro Ochiya, Ryo Matoba, Shoji Tajima, Kenta Nakai, Asao Fujiyama, Mika Kimura, Takuro Horii, Atsushi Toyoda, Riu Yamashita, Ryou-u Takahashi, Sumiyo Morita, Izuho Hatada
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 7, Pp 8259-8272 (2012)
DNA methylation of promoters is linked to transcriptional silencing of protein-coding genes, and its alteration plays important roles in cancer formation. For example, hypermethylation of tumor suppressor genes has been seen in some cancers. Alterati
Externí odkaz:
https://doaj.org/article/7cfdae1dfc6f4d9585448f34e0228723
Autor:
Ronald Garingalao Garvilles, Takashi Hasegawa, Hironobu Kimura, Jafar Sharif, Masahiro Muto, Haruhiko Koseki, Saori Takahashi, Isao Suetake, Shoji Tajima
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137509 (2015)
In mammals, DNA methylation plays important roles in embryogenesis and terminal differentiation via regulation of the transcription-competent chromatin state. The methylation patterns are propagated to the next generation during replication by mainte
Externí odkaz:
https://doaj.org/article/b7fff8447ad64168b1421b7b6a78296b
Autor:
Ryota Mizushima, Ju Yaen Kim, Isao Suetake, Hiroaki Tanaka, Tomoyo Takai, Narutoshi Kamiya, Yu Takano, Yuichi Mishima, Shoji Tajima, Yuji Goto, Kenji Fukui, Young-Ho Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98554 (2014)
MutL is a multi-domain protein comprising an N-terminal ATPase domain (NTD) and C-terminal dimerization domain (CTD), connected with flexible linker regions, that plays a key role in DNA mismatch repair. To expand understanding of the regulation mech
Externí odkaz:
https://doaj.org/article/aca89f16ab304fe4bed2c0498c10bed4
Autor:
Shunsuke Mori, Shigeyuki Nada, Hironobu Kimura, Shoji Tajima, Yusuke Takahashi, Ayaka Kitamura, Chitose Oneyama, Masato Okada
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88891 (2014)
The mechanistic target of rapamycin (mTOR) functions as a component of two large complexes, mTORC1 and mTORC2, which play crucial roles in regulating cell growth and homeostasis. However, the molecular mechanisms by which mTOR controls cell prolifera
Externí odkaz:
https://doaj.org/article/fcaa4ba4730f4236a3a5ef76b55ee5bc