Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Shoji SASAKI"'
Autor:
Yasushi Kimura, Mitsunori Maeda, Kiyoshi Kinoshita, Keiko Motoyama, Yuko Mitobe, Michio Fujiwara, Riichiro Yonezawa, Takeshi Okabe, Masayuki Tomohiro, Shoji Sasaki, Kazuto Watanabe
Publikováno v:
Toxicologic Pathology. 47:108-120
In nonclinical safety studies for new drug development, healthy animals have been commonly used. However, in some cases, the use of animal models of human disease is considered to be more favorable in evaluating risks in patients. To elucidate the cu
Publikováno v:
The Japanese Journal of Real Estate Sciences. 31:164-175
Publikováno v:
Journal of the Japan Society for Precision Engineering. 83:665-671
Autor:
Hiroshi Onodera1, Shoji Sasaki2, Seiji Otake3, Masayuki Tomohiro4 masayuki.tomohiro@alcon.com, Kazumoto Shibuya5, Mamoru Nomura6
Publikováno v:
Journal of Toxicological Sciences. Jun2015, Vol. 40 Issue 3, p295-307. 13p.
Publikováno v:
Journal of Toxicologic Pathology
Histopathology of the eye is an essential part of ocular toxicity evaluation. There are structural variations of the eye among several laboratory animals commonly used in toxicity studies, and many cases of ocular lesions in these animals are related
Publikováno v:
Journal of MMIJ. 129:29-35
Autor:
Seiya Maehara, Aya Shinozaki, Hiroki Teraoka, Shoji Sasaki, Tomohiro Imagawa, Masato Uehara, Norihiko Itoh, Naoharu Mizuno, Kentaro Endo, Takeo Hiraga
Publikováno v:
The journal of veterinary medical science. 70(2):139-144
Manganese deficiency results in neurological and skeletal defects, together with ultrastructural disarrangement of the retina in rats. Wild birds show a range of Mn concentrations in their tissues, including the liver, raising the possibility of Mn-r
Autor:
Ichiro TSUNENARI, Kyoko BARATA, Naoki NAKAYAMA, Shoichiro SUGAI, Motomu TAN, Shoji SASAKI, Takashi UNNO, Kazuhiko MATSUMOTO
Publikováno v:
Japanese Journal of Pharmacoepidemiology/Yakuzai ekigaku. 13:29-38
Autor:
Seiji Otake, Masayuki Tomohiro, Hiroshi Onodera, Kazumoto Shibuya, Shoji Sasaki, Mamoru Nomura
Publikováno v:
The Journal of toxicological sciences. 40(3)
Humans commonly obtain approximately 80% of external information from vision. Since loss of vision markedly decreases quality of life, risk assessments for visual toxicity of new drugs are extremely important. However, the ICH S4 guideline for noncli
Publikováno v:
Toxicology Letters. 166:115-121
We investigated full-field ERGs in beagle dogs using a contact lens electrode with built-in LED. Experiment 1 was performed to determine the appropriate conditions for stimulus intensity and background illumination. We found that full-field ERGs coul