Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Shoji Kawauchi"'
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Exosomes, small-membrane vesicles, are secreted by cells and include several types of proteins and nucleic acids. Exosomes transfer cellular information derived from donor cells and are involved in various physiological and pathol
Externí odkaz:
https://doaj.org/article/19199d62f4b84482b65132dfdbeb671a
Autor:
Shoji Kawauchi, Tsutomu Nakamura, Ikuya Miki, Jun Inoue, Tsuneo Hamaguchi, Toshihito Tanahashi, Shigeto Mizuno
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 2, Pp 180-191 (2014)
CYP3A and P-glycoprotein (P-gp) play important roles in drug metabolism and excretion; however, their functions in pathological conditions remain unclear. Hepatobiliary abnormalities have been described in patients with ulcerative colitis, which may
Externí odkaz:
https://doaj.org/article/8cb198a8544e4e818fc73f2d50bc32ac
Autor:
Shoji Kawauchi, Sayo Horibe, Naoto Sasaki, Toshihito Tanahashi, Shigeto Mizuno, Tsuneo Hamaguchi, Yoshiyuki Rikitake
Publikováno v:
Marine Drugs, Vol 17, Iss 2, p 104 (2019)
Nonalcoholic steatohepatitis (NASH) progresses from nonalcoholic fatty liver disease (NAFLD); however, efficacious drugs for NASH treatment are lacking. Sodium alginate (SA), a soluble dietary fiber extracted from brown algae, could protect the small
Externí odkaz:
https://doaj.org/article/2c938b7bdf25412bb72cd2956e540f33
Autor:
Shoji Kawauchi, Taiji Mizoguchi, Sayo Horibe, Toru Tanaka, Naoto Sasaki, Koji Ikeda, Noriaki Emoto, Ken‐ichi Hirata, Yoshiyuki Rikitake
Publikováno v:
Glia. 71:467-479
In the brain, neurons, glial cells, vascular endothelial cells (ECs), and mural cells form a functional structure referred to as the neurovascular unit (NVU). The functions of the NVU become impaired with aging. To gain insight into the mechanism und
Autor:
Sayo Horibe, Kaori Ishikawa, Kazuto Nakada, Masaki Wake, Norihiko Takeda, Toru Tanaka, Shoji Kawauchi, Naoto Sasaki, Yoshiyuki Rikitake
Publikováno v:
Oncology Reports
The efficacy of cisplatin (CDDP) has been demonstrated in the treatment of various cancers as monotherapy and combination therapy with immunotherapy. However, acquired CDDP resistance is a major obstacle to successful treatment. In the present study,
Publikováno v:
Experimental Cell Research. 374(2):333-341
Here, we developed a novel in vitro co-culture model, in which process-bearing astrocytes and isolated cerebral microvessels from mice were co-cultured. Astrocytes formed contacts with microvessels from both adult and neonatal mice. However, concentr
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 57:32-36
Objective Prior to heart transplant, sensitization to human leukocyte antigen can occur after blood transfusions used during implantation of ventricular assist devices. The result is an increased risk of antibody-mediated rejection (AMR) after heart
Autor:
Shigeto Mizuno, Shoji Kawauchi, Yoshiyuki Rikitake, Toshihito Tanahashi, Naoto Sasaki, Sayo Horibe
Publikováno v:
Biochemical and Biophysical Research Communications. 507:426-432
Cisplatin (CDDP) is widely used as an anti-cancer platinum agent but its therapeutic efficacy is limited by acquired drug resistance. To develop a new therapeutic strategy that could overcome this resistance, it is important to characterize CDDP-resi
Autor:
K Hirata, Shoji Kawauchi, Sayo Horibe, Naoto Sasaki, Yoshiyuki Rikitake, Hilman Zulkifli Amin
Publikováno v:
European Heart Journal. 41
Background Regulatory T cells (Tregs) are demonstrated to play a protective role in the development of atherosclerosis. However, their sites of action in atherosclerosis remain unclear. Although C-C chemokine receptor 4 (CCR4) has been shown to contr
Autor:
Yoshiyuki Rikitake, Tokiko Tabata, Shoji Kawauchi, Takuya Matsumoto, Tomohiro Hayashi, Takuo Emoto, K Hirata, Naofumi Yoshida, Sayo Horibe, Tomoya Yamashita, Naoto Sasaki, Hilman Zulkifli Amin, Taiji Mizoguchi
Publikováno v:
European Heart Journal. 40
Aims Vascular inflammation via T-cell-mediated immune responses has been shown to be critically involved in the pathogenesis of abdominal aortic aneurysm (AAA). T-cell coinhibitory molecule cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) is kn