Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Shoji, Awazu"'
Publikováno v:
Chemico-Biological Interactions. 160:150-158
We previously showed that naproxen induced the oxidative stress in the liver microsomes and the isolated hepatocytes of rats. In this study, the in situ effect of naproxen on the rat liver tissue was investigated, using the isolated perfused liver fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1246035e8ac4b613e21ae8480c4231b8
https://doi.org/10.1016/j.cbi.2006.01.003
https://doi.org/10.1016/j.cbi.2006.01.003
Autor:
Shoji Awazu, Takashi Mizuma
Publikováno v:
Journal of Pharmaceutical Sciences. 93:2407-2410
The effect of dietary polyphenols on the intestinal glucuronidation and absorption of a model phenolic drug, α-naphthol (α-NA), was studied in isolated rat small intestine. (−)-Epicatechin significantly inhibited the glucuronidation of α-NA. Chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c382cbc34845d269e4edb195a4cba787
https://doi.org/10.1002/jps.20146
https://doi.org/10.1002/jps.20146
Autor:
Norihiko Fuseda, Akihiro Koyanagi, Takashi Mizuma, Katsura Hagi, Masahiro Hayashi, Takuo Narasaka, Shoji Awazu, Seiichi Matsumoto
Publikováno v:
Drug Metabolism and Pharmacokinetics. 16:258-263
We have studied intestinal metabolism and transport, which is considered to be sequential (1) or competitive (2) process in absorption (Scheme 1). (1) Disaccharide (maltose, cellobiose, lactose) conjugates of p-nitrophenol were hydrolyzed to p-nitrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff6452ab1cdf157cfe1d0a02ab6b296
https://doi.org/10.2133/dmpk.16.258
https://doi.org/10.2133/dmpk.16.258
Autor:
Rie Ohkubo, Shoji Awazu, Sotaro Sadahiro, Masahiro Hayashi, Yoshiyuki Hotta, Tatsuya Shimazaki, Mikio Tomita, Mayuko Nagira
Publikováno v:
Drug Metabolism and Pharmacokinetics. 16:1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::432a815113e69ba6ab4079e2f8e671c7
https://doi.org/10.2133/dmpk.16.1
https://doi.org/10.2133/dmpk.16.1
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1475:90-98
Intestinal transport and metabolism of modified kyotorphin (KTP) were studied in rats. Modified KTPs studied were C-terminally modified KTP with p-aminophenyl-beta-D-glucoside (KTP-pAPbeta glc), N-terminally modified KTP-pAPbeta glc with t-butyloxyca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3908b48960c4fd55be444539616219
https://doi.org/10.1016/s0304-4165(00)00051-9
https://doi.org/10.1016/s0304-4165(00)00051-9
Publikováno v:
Journal of Drug Targeting. 8:395-401
We examined the relation ship between the charge of the amino or carboxylic function of a substrate and the substrate recognition by the large neutral amino acid (LNAA) transport carrier, using the in situ brain perfusion technique. Glucose-coupled L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8368a6cc37f66dea8fd8f5df4e133d83
https://doi.org/10.3109/10611860008997915
https://doi.org/10.3109/10611860008997915
Publikováno v:
Japanese Journal of Hospital Pharmacy. 26:632-641
In order to study the proper use of urate-lowering drugs, we searched and analyzed a recently established database of 151, 804 community pharmacy records for the one-year period ending in August 1997. A total of 5, 312 prescriptions for typical urate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c19b7e1faeeec8771f331d394bc93059
https://doi.org/10.5649/jjphcs1975.26.632
https://doi.org/10.5649/jjphcs1975.26.632
Autor:
Shoji Awazu, Yoichi Itakura, Toru Fuwa, Madoka Kasagi, Akiko Sugiyama, Toshiharu Horie, Masako Kikuchi, Haruno Matsumoto, Chika Karasawa
Publikováno v:
Planta Medica. 65:545-548
The methotrexate (MTX) administration to rats causes the damage of small intestine. The small intestinal damage was evaluated by measuring the intestinal permeability of the poorly absorbable compound, fluorescein isothiocyanate (FITC)-labeled dextra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454658e44687acc419529d36c66147a2
https://doi.org/10.1055/s-1999-14023
https://doi.org/10.1055/s-1999-14023
Publikováno v:
Biological and Pharmaceutical Bulletin. 22:876-879
Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosylglycylglycine (CcpTGG) by intestinal Na+/glucose cotransporter (SGLT1) was examined in rat small intestine. Inhibitory effect of phloridzin (SGLT1 inhibitor) on the CcpTG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5cc96611a28ba852be923417b762f91
https://doi.org/10.1248/bpb.22.876
https://doi.org/10.1248/bpb.22.876
Publikováno v:
Drug Metabolism and Pharmacokinetics. 14:16-21
To examine whether the retention of imidazole analogues in the organ rich with elastic connective tissue can be of toxicological significance, the effect of 14C labeled 2-methylimidazole (2MI) as a model compound on the mechanical, biochemical, and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23aaadaff5b400747efc13f4f05961e4
https://doi.org/10.2133/dmpk.14.16
https://doi.org/10.2133/dmpk.14.16