Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Shoichiro, Kokabu"'
Autor:
Hiroka Kawaue, Takuma Matsubara, Kenichi Nagano, Aoi Ikedo, Thira Rojasawasthien, Anna Yoshimura, Chihiro Nakatomi, Yuuki Imai, Yoshimitsu Kakuta, William N. Addison, Shoichiro Kokabu
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110151- (2024)
Summary: Point mutations in KIF22 have been linked to spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2). Skeletal features of SEMDJL2 include short stature and joint laxity. Mechanisms underlying these limb abnormalities are unknow
Externí odkaz:
https://doaj.org/article/9b64d8867b6e44f994ee85e66decb252
Autor:
Masahiko Okubo, Motoyoshi Morishita, Tomoko Odani, Hideo Sakaguchi, Takeshi Kikutani, Shoichiro Kokabu
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
The world’s population is aging. Pneumonia is the leading cause of death among the older adults, with aspiration pneumonia being particularly common. Aspiration pneumonia is caused by a decline in swallowing function. Causes can include age-related
Externí odkaz:
https://doaj.org/article/be262de4e0174dcaa05c63a0b4827b93
Autor:
Takumi Ito, Thira Rojasawasthien, Sachiko Yamashita Takeuchi, Hideto Okamoto, Nobuaki Okumura, Tomohiko Shirakawa, Takuma Matsubara, Tatsuo Kawamoto, Shoichiro Kokabu
Publikováno v:
Molecules, Vol 29, Iss 7, p 1449 (2024)
Royal jelly (RJ) is recognized as beneficial to mammalian health. Multilineage differentiation potential is an important property of mesenchymal stem cells (MSCs). C2C12 cells have an innate ability to differentiate into myogenic cells. Like MSCs, C2
Externí odkaz:
https://doaj.org/article/840a465c85824d16acd5db3e5093906b
Autor:
Thira Rojasawasthien, Michihiko Usui, William N. Addison, Takuma Matsubara, Tomohiko Shirakawa, Toshiyuki Tsujisawa, Keisuke Nakashima, Shoichiro Kokabu
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 2, Pp 62-70 (2023)
Abstract The NF‐κB family of transcription factors plays an important role in skeletal development and bone homeostasis. In osteoblast cells, NF‐κB signaling has been shown to suppress survival, proliferation, and differentiation. Furthermore,
Externí odkaz:
https://doaj.org/article/3c44315372af4271895e6add1afd2384
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 12, p 568 (2023)
Ideal regeneration of hard tissue and dental pulp has been reported with the use of a combination of bioactive glass and basic fibroblast growth factor (bFGF). However, no previous study has investigated the molecular mechanisms underlying the proces
Externí odkaz:
https://doaj.org/article/e59b50994df14680bbf728837060ec37
Autor:
Kana Mizuta, Takuma Matsubara, Akino Goto, William N. Addison, Mitsushiro Nakatomi, Kou Matsuo, Yukiyo Tada-Shigeyama, Tatsuki Yaginuma, Hiromi Honda, Izumi Yoshioka, Shoichiro Kokabu
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated and promotes cell proli
Externí odkaz:
https://doaj.org/article/7e1df97397ab41238a3e2b83d5d9bd46
Autor:
Suzuro Hitomi, Tomotaka Nodai, Shoichiro Kokabu, Takemi Shikayama, Misa Sago-Ito, Chihiro Nakatomi, Kiyoshi Terawaki, Yuji Omiya, Masamichi Shinoda, Kentaro Ono
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284617 (2023)
Severe intraoral pain induces difficulty in eating and speaking, leading to a decline in the quality of life. However, the molecular mechanisms underlying intraoral pain remain unclear. Here, we investigated gene modulation in the trigeminal ganglion
Externí odkaz:
https://doaj.org/article/c5b38d86523848e28058a019a27e70a8
Autor:
Michihiko Usui, Satoru Onizuka, Tsuyoshi Sato, Shoichiro Kokabu, Wataru Ariyoshi, Keisuke Nakashima
Publikováno v:
Japanese Dental Science Review, Vol 57, Iss , Pp 201-208 (2021)
Periodontal disease is an inflammatory disease caused by periodontopathogenic bacteria, which eventually leads to bone tissue (alveolar bone) destruction as inflammation persists. Periodontal tissues have an immune system against the invasion of thes
Externí odkaz:
https://doaj.org/article/4a509389a44a423682535ff19adff70b
Autor:
Asako Inoue, Kayoko Nakao‐Kuroishi, Kaori Kometani‐Gunjigake, Masahiro Mizuhara, Tomohiko Shirakawa, Misa Ito‐Sago, Kazuma Yasuda, Mitsushiro Nakatomi, Takuma Matsubara, Yukiyo Tada‐Shigeyama, Kazumasa Morikawa, Shoichiro Kokabu, Tatsuo Kawamoto
Publikováno v:
FEBS Open Bio, Vol 10, Iss 8, Pp 1612-1623 (2020)
Osteoblasts release adenosine triphosphate (ATP) out of the cell following mechanical stress. Although it is well established that extracellular ATP affects bone metabolism via P2 receptors [such as purinergic receptor P2X7 (P2X7R) and purinergic rec
Externí odkaz:
https://doaj.org/article/141582fa0c714d33b74d6334c5dbebfa
Publikováno v:
Case Reports in Dentistry, Vol 2022 (2022)
Membranous substances in the pharynx are occasionally observed in tube feeding patients during the fiberoptic endoscopic evaluation of swallowing. Although the mechanism of the formation of these deposits sometimes causes problems, such as dysphagia,
Externí odkaz:
https://doaj.org/article/edf4e2451e534b4d8c025d5f67a800e6