Výsledky vyhledávání - "Shoichi Shiramoto"

Tumor targeting based on the effect of enhanced permeability and retention (EPR) and the mechanism of receptor-mediated endocytosis (RME)

Autor: Yuko Fujishima, Shoichi Shiramoto, Yoshiharu Kaneo, Tetsuro Tanaka, Masahide Miyashita

Publikováno v: International Journal of Pharmaceutics. 277:39-61

This review is focused on the macromolecular drug carrier systems by the effect of enhanced permeability and retention (EPR) and the mechanism of receptor-mediated endocytosis (RME). The effect of EPR is thought to be useful for the targeting of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1d6b3a75a6a490f83bfd16ff1d1f10
https://doi.org/10.1016/j.ijpharm.2003.09.050

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Adrenomedullin increases phosphatidylcholine secretion in rat type II pneumocytes

Autor: Muneaki Hidaka, Manabu Okumura, Shoichi Shiramoto, Yoichiro Isohama, Tomomi Iwakiri, Takeshi Miyata, Hirofumi Kai, Kazuhiko Arimori

Publikováno v: European Journal of Pharmacology. 403:189-194

Adrenomedullin, a novel hypotensive peptide, has been reported to be produced in the lung as well as in the adrenal medulla. However, the effect of adrenomedullin on lung function is still poorly understood. In this study, we detected the expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b15aececbf935ec41347899c3396f9
https://doi.org/10.1016/s0014-2999(00)00494-5

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Investigation of the Therapeutic Drug Monitoring of Valproic Acid(VAP) and the Effects of Other Epileptics on the Concentration of VAP at Miyazaki Medical College Hospital

Autor: Hirofumi Kodama, Manabu Okumura, Shoichi Shiramoto, Norito Takamura, Shinya Shinozawa, Tomohide Maeda

Publikováno v: Japanese Journal of Hospital Pharmacy. 24:513-519

The present study was undertaken to investigate the annual number of antiepileptic drug monitoring samples (mainly valproic acid, VAP), the rate of effective therapeutic concentration area and the effect of other epileptics on the serum concentration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94d4d5066986f07a634dfd9e793dfab8
https://doi.org/10.5649/jjphcs1975.24.513

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Properties of Water-Insoluble Mitomycin C-Albumin Conjugate as a Sustained Release Drug Delivery System in Mice Inoculated with Sarcoma 180

Autor: Yoshiharu Kaneo, Tetsuro Tanaka, Shoichi Shiramoto, Masahide Miyashita

Publikováno v: Biological and Pharmaceutical Bulletin. 18:1724-1728

In order to improve the deposition of mitomycin C (MMC) in the administered site, water-insoluble mitomycin C-albumin conjugate (MMC-G-BSA) was prepared. MMC was covalently attached to the glutarylated bovine serum albumin (G-BSA) in the presence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81369e76277dc5683353c11d2b341a12
https://doi.org/10.1248/bpb.18.1724

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The Disposition of Serum Proteins as Drug-Carriers in Mice Bearing Sarcoma 180

Autor: Sadao Iguchi, Shoichi Shiramoto, Tetsuro Tanaka, Yoshiharu Kaneo

Publikováno v: Biological and Pharmaceutical Bulletin. 16:1270-1275

The tumor distribution and the disposition of serum proteins, such as albumin, fetuin, transferrin, and IgG, were investigated in mice bearing Sarcoma 180. Serum proteins labeled with fluoresceinisothiocyanate (FITC) were administered to the mice. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30c8b672e1ffb71aa107e424637d1dc
https://doi.org/10.1248/bpb.16.1270

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