Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Shoichi Fukayama"'
Autor:
Jing Zhang, Christine Huard, Sung Choe, Michael Cain, Ying Zhang, Yan Liu, Bheem M. Bhat, Ramesh A. Bhat, Stephen P. Berasi, Shoichi Fukayama, Kathryn L Auld, Robert V. Martinez, Wenyan Zhong, Eugene L. Brown
Publikováno v:
Journal of Molecular Endocrinology. 48:177-191
Based on its homology to the estrogen receptor and its roles in osteoblast and chondrocyte differentiation, the orphan nuclear receptor estrogen-related receptor α (ERRα (ESRRA)) is an intriguing therapeutic target for osteoporosis and other bone d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb07675aab1e4cb87d02c81bb6fe3c61
https://doi.org/10.1530/jme-11-0140
https://doi.org/10.1530/jme-11-0140
Publikováno v:
Proceedings of the National Academy of Sciences. 92:10182-10186
Parathyroid hormone-related protein (PTHrP) is synthesized in the brain, and a single type of cloned receptor for the N-terminal portion of PTHrP and PTH is present in the central nervous system. Nothing is known about the physiological actions or si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392c01a00964c4b466fe2b3274436e21
https://doi.org/10.1073/pnas.92.22.10182
https://doi.org/10.1073/pnas.92.22.10182
Autor:
Abdul-Badi Abou-Samra, Shoichi Fukayama, Henry M. Kronenberg, F. R. Bringhurst, Ernestina Schipani, Harald Jüppner, Beate Lanske
Publikováno v:
Endocrinology. 134:1851-1858
Homologous down-regulation of PTH/PTH-related peptide (PTHrP) receptor expression occurs in several PTH-responsive osteoblastic cell lines, but the mechanisms responsible are not well understood. We have used wild-type SaOS-2 human osteoblastic cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce14fb568fdd375056b9220f5c826e2a
https://doi.org/10.1210/endo.134.4.8137752
https://doi.org/10.1210/endo.134.4.8137752
Differential regulation of the PTH/PTHrP receptor and its mRNA in human osteoblast-like SaOS-2 cells
Publikováno v:
Journal of Bone and Mineral Metabolism. 12:S175-S181
Using wild-type SaOS-2 cells and a mutant cAMP-resistant subclone Ca#4A, we have recently shown that homologous down-regulation of PTH/PTHrP receptor (PTH/PTHrPR) is mediated by mechanisms independent of PKA activation, and that homologous down-regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33d4768a8c466f7fae66f36950f10d4f
https://doi.org/10.1007/bf02375699
https://doi.org/10.1007/bf02375699
Autor:
Laura L. Carter, Barry S. Komm, Dharmesh Patel, Yanong D Wang, Yogendra P. Kharode, Shoichi Fukayama, Max Follettie, Jeanne J. Matteo, Jason Jussif, Vikki Spaulding, Yao-Bin Liu, Frank Boschelli, Giovan Lane, Yuchen Bai, Frederick J. Bex, Veronica Diesl, X. Jian Li, Richard J. Murrills, Colleen Milligan, Diane H. Boschelli, Peter V.N. Bodine, John C McKew, Jennifer M. Golas, Susan Lockhead, Jane Owens
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 340(3)
Src-null mice have higher bone mass because of decreased bone resorption and increased bone formation, whereas Abl-null mice are osteopenic, because of decreased bone formation. Compound I, a potent inhibitor of Src in an isolated enzyme assay (IC(50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8220d8c757b207802a58b0d65b486413
https://pubmed.ncbi.nlm.nih.gov/22171089
https://pubmed.ncbi.nlm.nih.gov/22171089
Autor:
Mengxiao Shi, Laura M. Seestaller-Wehr, Peter V.N. Bodine, Helga Ponce-de-Leon, Barbara Stauffer, Annamarie Mangine, Robert Moran, Ariamala Gopalsamy, Girija Krishnamurthy, Julia Billiard, Shoichi Fukayama, Ramesh A. Bhat
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(22)
Secreted frizzled related protein-1 (sFRP-1) inhibitors have the potential to be used for the treatment of osteoporosis or other bone related disorders, since the level of sFRP-1 affects osteoblast apoptosis and proliferation. From high throughput sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bd967816827b9d82087d6ae5588ed4
https://pubmed.ncbi.nlm.nih.gov/19819694
https://pubmed.ncbi.nlm.nih.gov/19819694
Autor:
Jeffrey Curtis Kern, Peter V.N. Bodine, Shoichi Fukayama, Gregory S. Welmaker, Girija Krishnamurthy, Thomas Joseph Commons, Lisa Nogle, William Jay Moore, Ramesh A. Bhat, Keith Pitts, Eugene John Trybulski, Barb Stauffer, Wilson Matthew Allan, Igor Goljer, Ronald L. Magolda
Publikováno v:
Journal of medicinal chemistry. 52(1)
The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0856734d48b2f78ae9483671c5b4443c
https://pubmed.ncbi.nlm.nih.gov/19072540
https://pubmed.ncbi.nlm.nih.gov/19072540
Autor:
Barbara Stauffer, Julia Billiard, Mengxiao Shi, Laura M. Seestaller-Wehr, Girija Krishnamurthy, Ramesh Bahat, Shoichi Fukayama, Helga Ponce-de-Leon, Annamarie Mangine, Robert Moran, Peter V.N. Bodine, Ariamala Gopalsamy
Publikováno v:
Journal of medicinal chemistry. 51(24)
Inhibitor of secreted frizzled related protein-1 (sFRP-1) would be a novel potential osteogenic agent, since loss of sFRP-1 affects osteoblast proliferation, differentiation, and activity, resulting in improved bone mineral density, quality, and stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d21f9738e52000bc7246b31c7dd128
https://pubmed.ncbi.nlm.nih.gov/19053830
https://pubmed.ncbi.nlm.nih.gov/19053830
Autor:
Jeffrey Curtis Kern, Shoichi Fukayama, Gregory S. Welmaker, Mengxiao Shi, Thomas Joseph Commons, Richard Page Woodworth, Barry S. Komm, Robert A. Moran, Girija Krishnamurthy, Wilson Matthew Allan, Ramesh A. Bhat, Annamarie Mangine, Peter V.N. Bodine, Laura M. Seestaller-Wehr, William Jay Moore, Keith Pitts, Eugene John Trybulski, Barbara Stauffer, Julia Billiard, Ariamala Gopalsamy, Helga Ponce-de-Leon
Publikováno v:
Bone. 44(6)
Canonical Wnt signaling has been demonstrated to increase bone formation, and Wnt pathway components are being pursued as potential drug targets for osteoporosis and other metabolic bone diseases. Deletion of the Wnt antagonist secreted frizzled-rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca48c16a82a8b27c92ce162b2bb041c3
https://pubmed.ncbi.nlm.nih.gov/19254787
https://pubmed.ncbi.nlm.nih.gov/19254787
Autor:
Shoichi Fukayama, Armen H. Tashjian
Publikováno v:
Endocrinology. 126:1941-1949
We have investigated the actions of human PTH [hPTH-(1-34)] on the association of 45Ca2+ with two human (SaOS-2 and MG-63) and two rat (ROS 17/2.8 and UMR-106) osteoblast-like cell types. In SaOS-2 cells, hPTH-(1-34) binds to specific membrane recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb04d116686e93779e73c6c0f8cb043
https://doi.org/10.1210/endo-126-4-1941
https://doi.org/10.1210/endo-126-4-1941