Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Shohreh Issazadeh‐Navikas"'
Autor:
Elham Jaberi, Emilie Tresse, Kirsten Grønbæk, Joachim Weischenfeldt, Shohreh Issazadeh-Navikas
Publikováno v:
EBioMedicine, Vol 57, Iss , Pp 102868- (2020)
Background: Point mutations and structural variations (SVs) in mitochondrial DNA (mtDNA) contribute to many neurodegenerative diseases. Technical limitations and heteroplasmy, however, have impeded their identification, preventing these changes from
Externí odkaz:
https://doaj.org/article/bd07e6c2fdc94842820b8d8aa555511f
Autor:
Anne Skøttrup Mørkholt, Michal Krystian Oklinski, Agnete Larsen, Robert Bockermann, Shohreh Issazadeh-Navikas, Jette Goller Kloth Nieland, Tae-Hwan Kwon, Angelique Corthals, Søren Nielsen, John Dirk Vestergaard Nieland
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234493 (2020)
Multiple sclerosis (MS) is a neurodegenerative disease characterized by demyelination and inflammation. Dysregulated lipid metabolism and mitochondrial dysfunction are hypothesized to play a key role in MS. Carnitine Palmitoyl Transferase 1 (CPT1) is
Externí odkaz:
https://doaj.org/article/4fecd744134c40f689b6995a33e116c1
Autor:
Camilla Nehammer, Patrick Ejlerskov, Sandeep Gopal, Ava Handley, Leelee Ng, Pedro Moreira, Huikyong Lee, Shohreh Issazadeh-Navikas, David C Rubinsztein, Roger Pocock
Publikováno v:
eLife, Vol 8 (2019)
Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival. Here, we report that t
Externí odkaz:
https://doaj.org/article/7754acd69e6e4aa79dbca4943f8442d1
Autor:
Julie Ry Gustafsson, Georgia Katsioudi, Matilda Degn, Patrick Ejlerskov, Shohreh Issazadeh-Navikas, Birgitte Rahbek Kornum
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-16 (2018)
Abstract Major Histocompability Complex I (MHC-I) molecules present cellularly derived peptides to the adaptive immune system. Generally MHC-I is not expressed on healthy post-mitotic neurons in the central nervous system, but it is known to increase
Externí odkaz:
https://doaj.org/article/0c073fefa8ae455abe8476bfa3bdcad2
Autor:
Yawei Liu, Andrea Marin, Patrick Ejlerskov, Louise Munk Rasmussen, Marco Prinz, Shohreh Issazadeh-Navikas
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Neurons can convert pathogenic T cells to anti-inflammatory FoxA1+ regulatory T cells (Tregs), which can ameliorate EAE, but the molecular mechanism is only partially understood. Liu et al. show that autocrine interferon β signalling induces PDL1 ex
Externí odkaz:
https://doaj.org/article/ba089271c5bc48e1b485d5bb3165bf47
Autor:
Thomas Urup, Line Mærsk Staunstrup, Signe Regner Michaelsen, Kristoffer Vitting-Seerup, Marc Bennedbæk, Anders Toft, Lars Rønn Olsen, Lars Jønson, Shohreh Issazadeh-Navikas, Helle Broholm, Petra Hamerlik, Hans Skovgaard Poulsen, Ulrik Lassen
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background Bevacizumab combined with chemotherapy produces clinical durable response in 25–30% of recurrent glioblastoma patients. This group of patients has shown improved survival and quality of life. The aim of this study was to investi
Externí odkaz:
https://doaj.org/article/d6cd520ea2664653a177429de6ebebb1
Autor:
Thomas Urup, Signe Regner Michaelsen, Lars Rønn Olsen, Anders Toft, Ib Jarle Christensen, Kirsten Grunnet, Ole Winther, Helle Broholm, Michael Kosteljanetz, Shohreh Issazadeh-Navikas, Hans Skovgaard Poulsen, Ulrik Lassen
Publikováno v:
Molecular Oncology, Vol 10, Iss 8, Pp 1160-1168 (2016)
Background Bevacizumab combination therapy is among the most frequently used treatments in recurrent glioblastoma and patients who achieve response to bevacizumab have improved survival as well as quality of life. Accordingly, the aim of this study w
Externí odkaz:
https://doaj.org/article/bd720aa45e524484b30672fdd8de1366
Autor:
Isaac Hurtado-Guerrero, Bruno Hernáez, María J. Pinto-Medel, Esther Calonge, José L. Rodriguez-Bada, Patricia Urbaneja, Ana Alonso, Natalia Mena-Vázquez, Pablo Aliaga, Shohreh Issazadeh-Navikas, José Pavia, Laura Leyva, José Alcamí, Antonio Alcamí, Óscar Fernández, Begoña Oliver-Martos
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 4, p 959 (2020)
Soluble receptors of cytokines are able to modify cytokine activities and therefore the immune system, and some have intrinsic biological activities without mediation from their cytokines. The soluble interferon beta (IFN-ß) receptor is generated th
Externí odkaz:
https://doaj.org/article/f2cf7863cc0f44bfb417f393faa3b629
Autor:
Alba Manresa-Arraut, Flemming Fryd Johansen, Cord Brakebusch, Shohreh Issazadeh-Navikas, Henrik Hasseldam
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
T-cells are known to be intimately involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). T-cell activation is controlled by a range of intracellular signaling pathways regulating
Externí odkaz:
https://doaj.org/article/026acbef7ed748a7bfaf311f9ba1ee89
Autor:
Yawei Liu, Andrea Marin, Patrick Ejlerskov, Louise Munk Rasmussen, Marco Prinz, Shohreh Issazadeh-Navikas
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number: 14709 (2017); Published 24 April 2017; Updated 22 May 2017 The affiliation details for Marco Prinz are incorrect in this Article. The correct affiliation details for this author are given below: Institute of N
Externí odkaz:
https://doaj.org/article/3ce92b2f4fde4a7a866aa1feaf8ece19