Výsledky vyhledávání - "Shohini Mukherjee"

Optimization and validation of a reporter gene assay for screening of phosphodiesterase inhibitors in a high throughput system

Autor: Shohini Mukherjee, Abhijit Ray, Mou Chatterjee, Ranjana Arya, Kulvinder Singh Saini, Kamna Nanda, Sunanda G. Dastidar

Publikováno v: Biotechnology Journal. 3:1276-1279

Phosphodiesterases (PDEs) hydrolyze cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and guanosine monophosphate (cGMP) into inactive 5' monophosphates, and exist as 11 families. Inhibitors of PDEs allow the elevation of cAMP and cGMP, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7ac03200ac832990dff4111aea6bcb
https://doi.org/10.1002/biot.200800102

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Production and characterization of pharmacologically active recombinant human phosphodiesterase 4B in Dictyostelium discoideum

Autor: Roop Singh Bora, Lalitha Vijayakrishnan, Saima Aslam, Ranjana Arya, Shohini Mukherjee, Sunanda G. Dastidar, Alok Bhattacharya, Kulvinder Singh Saini, Pankaj Gulati, Sudha Naithani, Shivani Gupta

Publikováno v: Biotechnology journal. 3(7)

Phosphodiesterase 4B (PDE4B) is an important therapeutic target for asthma and chronic obstructive pulmonary disease. To identify PDE4 subtype-specific compounds using high-throughput assays, full-length recombinant PDE4 proteins are needed in bulk q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59011174fcea5a8cb7f255db136dbf25
https://pubmed.ncbi.nlm.nih.gov/18348140

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