Pancreatic tumor microenvironmental acidosis and hypoxia transform gold nanorods into cell-penetrant particles for potent radiosensitization.

Autor: Rauta PR; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA., Mackeyev Y; Vivian L. Smith Department of Neurosurgery, UTHealth, Houston, TX, USA., Sanders K; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA., Kim JBK; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA., Gonzalez VV; Vivian L. Smith Department of Neurosurgery, UTHealth, Houston, TX, USA., Zahra Y; Vivian L. Smith Department of Neurosurgery, UTHealth, Houston, TX, USA., Shohayeb MA; Vivian L. Smith Department of Neurosurgery, UTHealth, Houston, TX, USA., Abousaida B; Vivian L. Smith Department of Neurosurgery, UTHealth, Houston, TX, USA., Vijay GV; Vivian L. Smith Department of Neurosurgery, UTHealth, Houston, TX, USA., Tezcan O; Vivian L. Smith Department of Neurosurgery, UTHealth, Houston, TX, USA., Derry P; Department of Chemistry, Rice University, Houston, TX, USA., Liopo AV; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA., Zubarev ER; Department of Chemistry, Rice University, Houston, TX, USA., Carter R; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA., Singh P; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA., Krishnan S; Vivian L. Smith Department of Neurosurgery, UTHealth, Houston, TX, USA.

Publikováno v: Science advances [Sci Adv] 2022 Nov 11; Vol. 8 (45), pp. eabm9729. Date of Electronic Publication: 2022 Nov 11.