Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Shogo Tokuyama"'
Publikováno v:
Neuropsychopharmacology Reports, Vol 42, Iss 1, Pp 52-58 (2022)
Abstract Aims Fatty acid–binding protein (FABP) regulates polyunsaturated fatty acid (PUFA) intracellular trafficking and signal transduction. Our previous studies demonstrated that the alteration of PUFA in the hypothalamus is involved in pain pro
Externí odkaz:
https://doaj.org/article/6971315f2a5144cb968999ca82395c09
Autor:
Kazuo Nakamoto, Shogo Tokuyama
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11713 (2023)
Early life stress, such as child abuse and neglect, and psychosocial stress in adulthood are risk factors for psychiatric disorders, including depression and anxiety. Furthermore, exposure to these stresses affects the sensitivity to pain stimuli and
Externí odkaz:
https://doaj.org/article/e49b619619774e3dbb34ab4e62c28561
Autor:
Yuko Sadamura, Shanta Thapa, Ryota Mizunuma, Yuki Kambe, Akira Hirasawa, Kazuo Nakamoto, Shogo Tokuyama, Koji Yoshimoto, Kazunori Arita, Atsuro Miyata, Tatsuki Oyoshi, Takashi Kurihara
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The free fatty acid receptor 1 (FFAR1) is suggested to function as a G protein-coupled receptor (GPR40) for medium-to-long-chain free fatty acids. Previous studies on the expression of FFAR1 revealed that the nigrostriatal region is one of the areas
Externí odkaz:
https://doaj.org/article/9238288067b749e18effdf1e453f8e7a
Autor:
Sachi Matsuda, Hiroyuki Nishikawa, Anna Fukatsu, Yuko Kurokawa, Maho Tsubota, Fumiko Sekiguchi, Shogo Tokuyama, Atsufumi Kawabata
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 2, Pp 193-196 (2019)
We tested whether NNC 55-0396 (NNC), a T-type calcium channel (T-channel) blocker, reduces the brain injury caused by middle cerebral artery occlusion and reperfusion (MCAO/R) in mice. NNC, administered i.c.v. before the occlusion, greatly reduced th
Externí odkaz:
https://doaj.org/article/7e868b89312d433c92ffd73f6b41e73c
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 4, Pp 240-246 (2018)
Cerebral ischemic stress increases cerebral sodium-glucose transporter type 1 (SGLT-1). However, the mechanism by which cerebral ischemia leads to the up-regulation of SGLT-1 remains unclear. In peripheral tissue, the activation of mitogen-activated
Externí odkaz:
https://doaj.org/article/631f10d16aee4665a95ec2ee936941a0
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 3, Pp 243- (2020)
Externí odkaz:
https://doaj.org/article/96d419a11b6f454ea80f738f34833b42
Publikováno v:
Journal of Pharmacological Sciences, Vol 142, Iss 4, Pp 176- (2020)
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).This article has been retracted at the request of the Authors. In Figure 1C some of the number
Externí odkaz:
https://doaj.org/article/b47113f356a14db8a26dc42e5c89b4b7
Autor:
Fuka Aizawa, Takashi Nishinaka, Takuya Yamashita, Kazuo Nakamoto, Takashi Kurihara, Akira Hirasawa, Fumiyo Kasuya, Atsuro Miyata, Shogo Tokuyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 4, Pp 249-254 (2016)
The free fatty acid receptor 1 (GPR40/FFAR1) is a G protein-coupled receptor, which is activated by long chain fatty acids. We have previously demonstrated that activation of brain GPR40/FFAR1 exerts an antinociceptive effect that is mediated by the
Externí odkaz:
https://doaj.org/article/3aad26b6d1e04c5194e19fc15be5d834
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Our previous studies demonstrated that emotional dysfunction associated with early life stress exacerbated nerve injury-induced mechanical allodynia. Sex differences were observed in several anxiety tests, but not in mechanical allodynia. To elucidat
Externí odkaz:
https://doaj.org/article/84475fa67b7f4cfe9799101bb4112fc6
Autor:
Kazuo Nakamoto, Fuka Aizawa, Kei Miyagi, Takuya Yamashita, Mitsumasa Mankura, Yutaka Koyama, Fumiyo Kasuya, Akira Hirasawa, Takashi Kurihara, Atsuro Miyata, Shogo Tokuyama
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180610 (2017)
We previously showed that activation of G protein-coupled receptor 40/free fatty acid receptor 1 (GPR40/FFAR1) signaling modulates descending inhibition of pain. In this study, we investigated the involvement of fatty acid-GPR40/FFAR1 signaling in th
Externí odkaz:
https://doaj.org/article/9744065312eb4d3bb8e4c30d79913407