Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Shogo Takahashi"'
Autor:
Shogo Takahashi, Frank J. Gonzalez
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 6, Pp 101400- (2024)
Externí odkaz:
https://doaj.org/article/5d55e723cead467db7c2d19569299129
Autor:
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R. Rocha, James P. Coleman, Chenran Zhang, Robert G. Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W. Krausz, Curtis C. Harris, Andrew D. Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J. Gonzalez
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Non-enterotoxigenic Bacteroides fragilis (NTBF) is abundant in colorectal cancer (CRC) patients and in a high-fat diet (HFD)-induced CRC model. Here the authors show that bile salt hydrolase-expressing NTBF is enriched in CRC patients with overweight
Externí odkaz:
https://doaj.org/article/81ef42b6daf243ddb4b812fae07958c9
Autor:
Thomas J. Velenosi, Kristopher W. Krausz, Keisuke Hamada, Tiffany H. Dorsey, Stefan Ambs, Shogo Takahashi, Frank J. Gonzalez
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-11 (2022)
Abstract Triple-negative breast cancer (TNBC) patients receive chemotherapy treatment, including doxorubicin, due to the lack of targeted therapies. Drug resistance is a major cause of treatment failure in TNBC and therefore, there is a need to ident
Externí odkaz:
https://doaj.org/article/25dda64b91734e499386bd331a57f043
Autor:
Bandar D. Alrehaili, Mikang Lee, Shogo Takahashi, Robert Novak, Bipin Rimal, Shannon Boehme, Samuel A. J. Trammell, Trisha J. Grevengoed, Devendra Kumar, Yazen Alnouti, Katya Chiti, Xinwen Wang, Andrew D. Patterson, John Y. L. Chiang, Frank J. Gonzalez, Yoon‐Kwang Lee
Publikováno v:
Hepatology Communications, Vol 6, Iss 10, Pp 2765-2780 (2022)
Abstract Bile acid‐CoA: amino acid N‐acyltransferase (BAAT) catalyzes bile acid conjugation, the last step in bile acid synthesis. BAAT gene mutation in humans results in hypercholanemia, growth retardation, and fat‐soluble vitamin insufficienc
Externí odkaz:
https://doaj.org/article/d79211ba0cd04455982000fdada5d57f
Autor:
Youbo Zhang, Tingting Yan, Tianxia Wang, Xiaoyan Liu, Keisuke Hamada, Dongxue Sun, Yizheng Sun, Yanfang Yang, Jing Wang, Shogo Takahashi, Qiong Wang, Kristopher W. Krausz, Changtao Jiang, Cen Xie, Xiuwei Yang, Frank J. Gonzalez
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 5, Pp 2224-2238 (2022)
Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been explored. Genetic ablation of the xenobiotic-metabolizing c
Externí odkaz:
https://doaj.org/article/e0119c1bf610483192e4b69183a90372
Autor:
Raja Gopal Reddy Mooli, Jessica Rodriguez, Shogo Takahashi, Sumeet Solanki, Frank J. Gonzalez, Sadeesh K. Ramakrishnan, Yatrik M. Shah
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 585-597 (2021)
Background & Aims: Fatty liver or nonalcoholic fatty liver disease (NAFLD) is the most common liver disease associated with comorbidities such as insulin resistance and cardiovascular and metabolic diseases. Chronic activation of hypoxic signaling, i
Externí odkaz:
https://doaj.org/article/ddbf79f26014419cb7dcf2170ec703f9
Autor:
Daisuke Aibara, Shogo Takahashi, Tomoki Yagai, Donghwan Kim, Chad N. Brocker, Moshe Levi, Kimihiko Matsusue, Frank J. Gonzalez
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104196- (2022)
Summary: Peroxisome proliferator-activated receptor α (PPARA) is a key mediator of lipid metabolism and inflammation. Activation of PPARA in rodents causes hepatocyte proliferation, but the underlying mechanism is poorly understood. This study focus
Externí odkaz:
https://doaj.org/article/3a21a97cbd064185964173dc54e370f8
Autor:
Chad N. Brocker, Donghwan Kim, Tisha Melia, Kritika Karri, Thomas J. Velenosi, Shogo Takahashi, Daisuke Aibara, Jessica A. Bonzo, Moshe Levi, David J. Waxman, Frank J. Gonzalez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
PPAR-alpha is a ligand responsive transcription factor that mediates energy metabolism during fasting in the liver. Here the authors show that Gm15441 is a PPAR-alpha dependent lncRNA that prevents the expression of its antisense transcript, thioredo
Externí odkaz:
https://doaj.org/article/1d2f0c30e94149ecae45a0d442e06efa
Autor:
Tomoki Yagai, Tingting Yan, Yuhong Luo, Shogo Takahashi, Daisuke Aibara, Donghwan Kim, Chad N. Brocker, Moshe Levi, Hozumi Motohashi, Frank J. Gonzalez
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109506- (2021)
Summary: Peroxisome proliferator-activated receptor α (PPARα) controls hepatic lipid homeostasis and is the target of lipid-lowering fibrate drugs. PPARα activation represses expression of let-7 microRNA (miRNA), but the function of let-7 in PPAR
Externí odkaz:
https://doaj.org/article/a30f895e50504b839fca8177cefe75ec
Autor:
Shogo Takahashi, Naoki Tanaka, Tatsuki Fukami, Cen Xie, Tomoki Yagai, Donghwan Kim, Thomas J. Velenosi, Tingting Yan, Kristopher W. Krausz, Moshe Levi, Frank J. Gonzalez
Publikováno v:
Hepatology Communications, Vol 2, Iss 12, Pp 1567-1582 (2018)
Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide, and an association between altered bile acid (BA) metabolism, down‐regulation of farnesoid X receptor (FXR), which is a master regulator of BA metabolism, and hepatocarci
Externí odkaz:
https://doaj.org/article/dfa052a0f4e946dfaf779f784ef1f2a2