Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shogo Nabe"'
Autor:
Junpei Suzuki, Takeshi Yamada, Kazuki Inoue, Shogo Nabe, Makoto Kuwahara, Nobuaki Takemori, Ayako Takemori, Seiji Matsuda, Makoto Kanoh, Yuuki Imai, Masaki Yasukawa, Masakatsu Yamashita
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
T cells can alter their metabolism during activation and differentiation. Here the authors show that the tumor suppressor menin regulates CD8 T-cell fate via the modulation of central carbon metabolism.
Externí odkaz:
https://doaj.org/article/ab20cf83169f418bb4198a412fbc757d
Autor:
Yukihiro Miyazaki, Koichiro Suemori, Nozomi Kuwahara, Yumi Taniguchi, Shinobu Murakami, Tatsuya Konishi, Shogo Nabe, Masaki Maruta, Toshiki Ochi, Kazushi Tanimoto, Hitoshi Miyamoto, Jun Yamanouchi, Hiromi Iwaki, Hiroto Shinomiya, Katsuto Takenaka
Publikováno v:
Japanese Journal of Transplantation and Cellular Therapy. 12:129-132
Autor:
Masaki MARUTA, Koichiro SUEMORI, Mashio TANIWAKI, Shinobu MURAKAMI, Mana FUKUSHIMA, Jun-ichi KATO, Hisafumi KIHARA, Shogo NABE, Yuichi IKEDA, Toshiki OCHI, Takashi HARO, Kazushi TANIMOTO, Kazuto TAKEUCHI, Jun YAMANOUCHI, Hitoshi MIYAMOTO, Katsuto TAKENAKA
Publikováno v:
Kansenshogaku Zasshi. 96:148-153
Autor:
Atsushi Shiraishi, Katsuto Takenaka, Koji Toriyama, Toshiaki Yasuoka, Shogo Nabe, Junpei Suzuki, Takeshi Yamada, Masakatsu Yamashita, Makoto Kuwahara, Masaki Yasukawa
Publikováno v:
Cancer Science. 109:3737-3750
The antitumor activity of activated CD8+ T cells in the tumor microenvironment seems to be limited due to their being metabolically unfit. This metabolic unfitness is closely associated with T-cell exhaustion and impairment of memory formation, which
Autor:
Masaki Maruta, Hiroshi Fujiwara, Yuichi Ikeda, Katsuto Takenaka, Kazushi Tanimoto, Sohei Kitazawa, Jun Yamanouchi, Shogo Nabe, Hiroaki Asai, Toshiki Ochi, Taichi Azuma, Kazuto Takeuchi
Publikováno v:
Annals of Hematology.
Publikováno v:
Gan to kagaku ryoho. Cancerchemotherapy. 47(1)
The cancer immunotherapies based on adoptive T cell therapy(ACT)has been receiving increased attention by improvement of the curative effect. T cells for ACT are harvested from the patient, then activated and expanded in vitro. However, in vitro acti
Autor:
Shogo Nabe, Yuuki Imai, Masaki Yasukawa, Ayako Takemori, Takeshi Yamada, Junpei Suzuki, Kazuki Inoue, Makoto Kanoh, Seiji Matsuda, Nobuaki Takemori, Makoto Kuwahara, Masakatsu Yamashita
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
While menin plays an important role in preventing T-cell dysfunction, such as senescence and exhaustion, the regulatory mechanisms remain unclear. We found that menin prevents the induction of dysfunction in activated CD8 T cells by restricting the c
Autor:
Siro Miura, Kazuto Takeuchi, Yuichi Ikeda, Takashi Haro, Yoshihiro Yakushijin, Kazushi Tanimoto, Kensuke Senzaki, Shogo Nabe, Toshiki Ochi, Jun Yamanouchi, Masaki Maruta, Jun-ichi Kato, Katsuto Takenaka
Publikováno v:
Annals of Oncology. 32:S356
Autor:
Saho Maruyama, Masakatsu Yamashita, Takuya Fujimoto, Masaki Yasukawa, Junpei Suzuki, Makoto Kanoh, Shogo Nabe, Takeshi Yamada, Akira Matsumoto, Toshiaki Yasuoka, Makoto Kuwahara, Ryo Sakisuka
Publikováno v:
The Journal of Immunology. 197:4079-4089
Menin, a tumor suppressor protein, is encoded by the MEN1 gene in humans. Certain germinal mutations of MEN1 induce an autosomal-dominant syndrome that is characterized by concurrent parathyroid adenomas and several other tumor types. Although menin
Autor:
Koji Toriyama, Katsuto Takenaka, Masakatsu Yamashita, Yuuki Imai, Atsushi Shiraishi, Junpei Suzuki, Masaki Yasukawa, Takeshi Yamada, Kazuki Inoue, Shogo Nabe
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 202(4)
Although the methylation status of histone H3K27 plays a critical role in CD4+ T cell differentiation and its function, the role of Utx histone H3K27 demethylase in the CD8+ T cell–dependent immune response remains unclear. We therefore generated T