Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Shobu Namura"'
Autor:
Shobu Namura, Lorenz Hirt, Vanessa C. Wheeler, Kim M. McGinnis, Paige Hilditch-Maguire, Michael A. Moskowitz, Marcy E. MacDonald, Francesca Persichetti
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 1, Pp 147-154 (2002)
Huntington's disease, with its dominant loss of striatal neurons, is triggered by an expanded glutamine tract in huntingtin. To investigate a proposed role for increased activation of the apoptotic cascade in mutant huntingtin's trigger mechanism, we
Externí odkaz:
https://doaj.org/article/97f8d2bb0483434288d7eb34b5d0e5ce
Publikováno v:
Stroke. 50
Shift work is associated with a higher risk of stroke, but the mechanisms of this relationship are unknown. Photic cues to the suprachiasmatic nucleus (SCN) are the primary source of environmental regulation for circadian rhythms, but non-photic cues
Autor:
Shobu Namura
Publikováno v:
Japanese Journal of Neurosurgery. 25:476-479
Autor:
Shobu Namura
Publikováno v:
Japanese Journal of Neurosurgery. 24:592-596
Publikováno v:
Annals of the New York Academy of Sciences. 1278:25-32
Cerebral ischemia, a focal or global insufficiency of blood flow to the brain, can arise through multiple mechanisms, including thrombosis and arterial hemorrhage. Ischemia is a major driver of stroke, one of the leading causes of morbidity and morta
Autor:
Shobu Namura, Guangming Wang
Publikováno v:
Neuroscience Research. 70:230-237
We examined whether chronic systemic treatment with agonists for peroxisome proliferator-activated receptor alpha (PPARα) influences neuroinflammation induced by lipopolysaccharide (LPS) injection into the somatosensory cortex in adult mice. Mice we
Publikováno v:
Brain Research. 1359:247-255
Fibrates are activators of peroxisome proliferator-activated receptor (PPAR) α. Pretreatment with fibrates has been shown to protect brain against ischemia in mice. We hypothesized that fibrates elevate superoxide dismutase (SOD) levels in the brain
Autor:
Shobu Namura, Qingmin Guo, Guangming Wang, Mohammed Hossain, Vince Fazio, Damir Janigro, Emil Zeynalov, Marc R. Mayberg
Publikováno v:
Brain Research. 1294:183-192
Matrix metalloproteinase (MMP)-9 has been shown to contribute to blood-brain barrier (BBB) disruption, infarct formation, and hemorrhagic transformation after ischemic stroke. The cellular source of MMP-9 detectable in the ischemic brain remains cont
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 30:70-78
Fibrates, one group of peroxisome proliferator-activated receptor (PPAR) activators, are lipid lowering drugs. Fibrates have been shown to attenuate brain tissue injury after focal cerebral ischemia. In this study, we investigated the impact of fenof
Publikováno v:
Stroke. 39:2099-2104
Background and Purpose— Filamentous middle cerebral artery occlusion (fMCAO) is the most frequently used focal cerebral ischemia model in rodents. The proximity of the ophthalmic artery to the middle cerebral artery suggests that fMCAO induces reti