Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shobhna Gopal"'
Autor:
Mathias Z. Strowski, Jill K. Fisher, Bei B. Zhang, Howard Y. Chen, Myrna E. Trumbauer, Martin Köhler, Hilary A. Wilkinson, Shobhna Gopal-Truter, Zhihua Li, James M. Schaeffer, Allan D. Blake, Deborah Szalkowski
Publikováno v:
Molecular Endocrinology. 17:93-106
Somatostatin (SRIF) regulates pancreatic insulin and glucagon secretion. In the present study we describe the generation of SRIF receptor subtype 5 knockout (sst(5) KO) mice to examine the role of SRIF receptor subtypes (sst) in regulating insulin se
Autor:
Xiao-Ming Guan, Douglas J. MacNeil, Myrna E. Trumbauer, Dawn E. Novi, Howard Y. Chen, Drew T. Weingarth, Yue Feng, Hong Yu, Airu Chen, Easter G. Frazier, Donald J. Marsh, Ramon E. Camacho, Shobhna Gopal-Truter, Lauren P. Shearman, Lex H.T. Van der Ploeg, Su Qian, Zhu Shen
Publikováno v:
Molecular and Cellular Biology. 22:5027-5035
Agouti-related protein (AgRP), a neuropeptide abundantly expressed in the arcuate nucleus of the hypothalamus, potently stimulates feeding and body weight gain in rodents. AgRP is believed to exert its effects through the blockade of signaling by alp
Autor:
Nicole A. Chartrain, Lucia Guh-Siesel, Jixiang Ding, Lu Yang, Michael M. Shen, Shobhna Gopal, John S. Mudgett
Publikováno v:
Proceedings of the National Academy of Sciences. 97:10454-10459
The p38 family of mitogen-activated protein kinases (MAPKs) mediates signaling in response to environmental stresses and inflammatory cytokines, but the requirements for the p38 MAPK pathway in normal mammalian development have not been elucidated. H
Autor:
Xiao-Ming Guan, Charles Rosenblum, Hong Yu, Yue Feng, D. Euan MacIntyre, Alison M. Strack, Lex H.T. Van der Ploeg, Christian N. Nunes, Airu S. Chen, Joseph M. Metzger, Linhai Cao, Easter G. Frazier, Jill K. Fisher, Ramon E. Camacho, William Min, Shobhna Gopal-Truter, Aurawan Vongs, Howard Y. Chen, Theodore N. Mellin, Donald J. Marsh, Myrna E. Trumbauer
Publikováno v:
Nature Genetics. 26:97-102
Genetic and pharmacological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological function of Mc3r, a melanocortin receptor expressed at high levels in the hypothalamus, has rema
Autor:
Donald J. Marsh, D. E. Macintyre, Xiao-Ming Guan, Michael J. Forrest, Easter G. Frazier, Airu S. Chen, Theodore N. Mellin, Ramon E. Camacho, Hong Yu, Jill K. Fisher, Van der Ploeg Lh, Joe Metzger, Alison M. Strack, Myrna E. Trumbauer, Howard Y. Chen, Shobhna Gopal-Truter
Publikováno v:
Transgenic Research. 9:145-154
We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic ra
Autor:
Kristy L. Kort, Myrna E. Trumbauer, Judith E. Miller, Howard Y. Chen, Deborah R. Marino, Shobhna Gopal, Thomas R. Skopek
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 400:77-88
Transgenic mutation assays utilizing bacterial target genes display a high frequency of spontaneous mutation at CpG sequences. This is believed to result from the fact that: (1) the prokaryotic genes currently being used as transgenic mutation target