Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Shobha N. Bhattachar"'
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c260fddd98f2ee2abcaa44b6ef6c7dd2
https://doi.org/10.1002/0471266949.bmc263
https://doi.org/10.1002/0471266949.bmc263
Autor:
Phenil J. Patel, Marieta Duvnjak Romic, Dipal Patel, Margaret S. Landis, Darren L. Reid, Shobha N. Bhattachar, Wenzhan Yang
Publikováno v:
Drug Discovery Today. 26:713-723
Drug-delivery technologies for modified drug release have been in existence for decades, but their utilization has been largely limited to post-launch efforts improving therapeutic outcomes. Recently, they have gained renewed importance because the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26581814597c35f626a2fb9bc9865bce
https://doi.org/10.1016/j.drudis.2020.12.008
https://doi.org/10.1016/j.drudis.2020.12.008
Autor:
Xueqian Gong, Karsten Boehnke, Carmen Baquero, Yue-Wei Qian, Gregory P. Donoho, Jason Manro, Robert T. Foreman, Carlos Marugán, Sonya C. Chapman, Yi Zeng, Phillip W Iversen, Jack A. Dempsey, Matthew Z. Dieter, David Anthony Barda, Henry James Robert, Michele Dowless, Shripad V. Bhagwat, Robert M. Campbell, Andrew Capen, Robert D. Van Horn, Amit Aggarwal, Mark S. Marshall, Darlene S. Barnard, Bharvin K. R. Patel, Louis Stancato, Huimin Bian, Li-Chun Chio, Sean Buchanan, Jian Du, Richard P. Beckmann, Christoph Reinhard, Ricardo Martinez, Gregory D. Plowman, Lei Yan, Shobha N. Bhattachar, Sarah M. Bogner, Maria Jose Lallena, Xiang S. Ye, Jennie L. Walgren, Yu-Hua Hui, Yue Webster, Emiko L. Kreklau, Raquel Torres, Yanzhu Yang, Bartley W. Halstead, Shaoyou Chu
Publikováno v:
Molecular Cancer Therapeutics. 18:2207-2219
Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle formation defects and consequently prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea271aab24607f19770d2cdca75d5d3
https://doi.org/10.1158/1535-7163.mct-18-0529
https://doi.org/10.1158/1535-7163.mct-18-0529
Autor:
Burkholder Timothy P, Maria-Carmen Fernandez, Gillig James Ronald, Lourdes Prieto, Miriam del Prado, Bo Tan, Genshi Zhao, Tao Wang, Robert L. Johnson, Yu-Hua Hui, Ken D. Roth, Shobha N. Bhattachar, Sean Buchanan, Xueqian Gong, Sandaruwan Geeganage, Robert L. Shepard, Ming-Shang Kuo, Colin F. Green, Lisa Kays, Wenjuan Wu, Sucai Dong
Publikováno v:
Molecular Cancer Therapeutics. 16:2677-2688
NAMPT, an enzyme essential for NAD+ biosynthesis, has been extensively studied as an anticancer target for developing potential novel therapeutics. Several NAMPT inhibitors have been discovered, some of which have been subjected to clinical investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9736cf2bc7ba0f8a4694e69d5907932
https://doi.org/10.1158/1535-7163.mct-16-0674
https://doi.org/10.1158/1535-7163.mct-16-0674
Autor:
Srinivasan Chandrasekhar, Bradley Condon, Matthew Allen Schiffler, Kuklish Steven Lee, Kim Euibong Jemes, Bryan H. Norman, John R. Rizzo, Jeremy Schulenburg York, Kristina M. Campanale, Stefan Jon Thibodeaux, Richard E. Rathmell, Michael J. Hickey, Christopher Groshong, Shobha N. Bhattachar, Norman Earle Hughes, Anita K. Harvey, John G. Luz, Stephen Antonysamy, Scott Alan Jones, Timothy Andrew Woods, Prashant V. Desai, Matthew J. Fisher, Xiao-Peng Yu, Thomas W. Seng
Publikováno v:
Journal of Medicinal Chemistry. 59:194-205
As part of a program aimed at the discovery of antinociceptive therapy for inflammatory conditions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 17.4 μM. Structural information was used to impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fa147abbccd68e15b02f28a0c1735a
https://doi.org/10.1021/acs.jmedchem.5b01249
https://doi.org/10.1021/acs.jmedchem.5b01249
Autor:
Shobha N. Bhattachar, Aktham Aburub, Xuan Ding, John P. Rose, David C. Sperry, Evelyn D. Lobo
Publikováno v:
Journal of pharmaceutical sciences. 108(1)
Relative bioavailability (RBA) studies are often carried out to bridge changes made between drug products used for clinical studies. In this work, we describe the development of a risk assessment (RA) tool that comprehensively and objectively assesse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837ee82826af2ac28174704431303d4f
https://pubmed.ncbi.nlm.nih.gov/30053554
https://pubmed.ncbi.nlm.nih.gov/30053554
Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter addr
Publikováno v:
AAPS PharmSciTech. 19(1)
This commentary reflects the collective view of pharmaceutical scientists from four different organizations with extensive experience in the field of drug discovery support. Herein, engaging discussion is presented on the current and future approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1205a581f11504b800b459818b185d14
https://pubmed.ncbi.nlm.nih.gov/28755053
https://pubmed.ncbi.nlm.nih.gov/28755053
Publikováno v:
Translating Molecules into Medicines ISBN: 9783319500409
The role of the developability (aka preformulation) scientist at the discovery development interface has been extensively discussed in the literature. In response to shifting trends in discovery and the continued push to shorten timelines and reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36dd9ad80cb9573af22b4b5e714b362d
https://doi.org/10.1007/978-3-319-50042-3_7
https://doi.org/10.1007/978-3-319-50042-3_7
Publikováno v:
AAPS Advances in the Pharmaceutical Sciences Series ISBN: 9783319500409
Translating Molecules into Medicines
Translating Molecules into Medicines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9503f5cdd20f18b5255c82a24474927
https://doi.org/10.1007/978-3-319-50042-3
https://doi.org/10.1007/978-3-319-50042-3