Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shobha E. Senadhi"'
Publikováno v:
International Journal of Peptide and Protein Research. 36:122-127
The conformation of a cyclic decapeptide analog of a repeat sequence of elastin has been determined in the crystalline state using X-ray crystallographic techniques. Tetragonal crystals were grown from a solution of the decapeptide in water; space gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2beb79af98f29363425d61286c0386
https://doi.org/10.1111/j.1399-3011.1990.tb00954.x
https://doi.org/10.1111/j.1399-3011.1990.tb00954.x
Autor:
Sankar Chatterjee, Shobha E. Senadhi, Zi-Qiang Gu, Rabindranath Tripathy, Mark A. Ator, Derek Dunn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2647-2652
The syntheses and biological activities of a series of calpain I inhibitors, derived from D- and L-Pro, are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43f1cb0bb6af11dcbdef487c34418f0
https://doi.org/10.1016/s0960-894x(98)00470-3
https://doi.org/10.1016/s0960-894x(98)00470-3
Autor:
Kurt A. Josef, Donna Bozyczko-Coyne, Zi-Qiang Gu, Sankar Chatterjee, Ming Tao, Rabindranath Tripathy, Ron Bihovsky, Mark A. Ator, Beth Ann McKenna, Shobha E. Senadhi, John P. Mallamo, Teresa M. O'Kane, Satish Mallya, Robert Siman, Derek Dunn
Publikováno v:
Journal of Medicinal Chemistry. 41:2663-2666
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602925a84b28f1f6315385e1e320e622
https://doi.org/10.1021/jm980035y
https://doi.org/10.1021/jm980035y
Autor:
Shobha E. Senadhi, Eric Griffith, Sheryl L. Meyer, Rabindranath Tripathy, William Biazzo, Sankar Chatterjee, Kurt A. Josef, Manoj Das, Bruce Dembofsky, Bethany Freed, Ming Tao, Patricia A. Messina, Robert Siman, Derek Dunn, Mark A. Ator, Ron Bihovsky, Mohamed Iqbal, Donna Bozyczko-Coyne
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:539-544
Dipeptide and tripeptide aldehydes have been evaluated as inhibitors of human calpain I. Dipeptide aldehydes are generally equipotent with tripeptide aldehydes. Calpain I possesses a rather stringent requirement for Leu at P2, but accepts a variety o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969c79285bb942274ed65d64259fb405
https://doi.org/10.1016/s0960-894x(97)00063-2
https://doi.org/10.1016/s0960-894x(97)00063-2
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:287-290
The syntheses and biological activities of novel nonpeptidic calpain inhibitors 2–3, 12, and 14, derived from 2-naphthalenethiol, are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47d9bc87c0a3af3891b0183aa2f979f4
https://doi.org/10.1016/s0960-894x(97)00003-6
https://doi.org/10.1016/s0960-894x(97)00003-6
Autor:
James C. Kauer, Donna Bozyczko-Coyne, Sankar Chatterjee, Robert Siman, Mohamed Iqbal, Shobha E. Senadhi, Satish Mallya, John P. Mallamo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1619-1622
Novel and potent, xanthene derived reversible aldehyde (7c) and α-ketocarboxamide (10a), and irreversible fluoromethyl ketone (10b) inhibitors of recombinant human calpain I are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4c07f9493135756b259c651600eeb68
https://doi.org/10.1016/s0960-894x(96)00286-7
https://doi.org/10.1016/s0960-894x(96)00286-7
Autor:
Mark A. Ator, Mohamed Iqbal, Kurt A. Josef, Robert Siman, Shobha E. Senadhi, Satish Mallya, John P. Mallamo, Donna Bozyczko-Coyne, Gregory J. Wells, Ron Bihovsky, Sankar Chatterjee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1237-1240
We report on a series of potent and selective dipeptide fluoromethyl ketone inhibitors of recombinant human calpain I. Compound 4f, having a tetrahydroisoquinoline containing urea motif as N-terminus capping group, is the most potent member ( k obs I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b50b5ac4651c74ff41b499b72e16566
https://doi.org/10.1016/0960-894x(96)00209-0
https://doi.org/10.1016/0960-894x(96)00209-0
Autor:
Sankar Chatterjee, Mark A. Ator, Derek Dunn, Zi-Qiang Gu, Rabindranath Tripathy, Shobha E. Senadhi
Publikováno v:
ChemInform. 30
The syntheses and biological activities of a series of calpain I inhibitors, derived from D- and L-Pro, are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28fedb518b76f569056b7ff6ea0c487c
https://doi.org/10.1002/chin.199907130
https://doi.org/10.1002/chin.199907130
Publikováno v:
Zeitschrift für Kristallographie. 202:1-6
C 7 H 9 NO 2 S, Mol wt = 171.1; monoclinic, P2 1 /n; Z = 4; F000 = 360; a = 6.590(4) A, b = 16.479(7) A, c = 7.710(5) A, β = 92.44°(3), V = 836.5(8) A 3 , Q c = 1.36 gm/cm 3 , λ = 1.5418 A, μ(CuKα) = 3.00 mm −1 , T = 294 K. The structure was d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11da51115d9a74e10de3ca3396396bac
https://doi.org/10.1524/zkri.1992.202.1-2.1
https://doi.org/10.1524/zkri.1992.202.1-2.1
Autor:
Alexander McPherson, Garry L. Taylor, Wilson Smith, S. Koszelak, L.L. Clancy, Daniel C. Carter, Kenneth L. Powell, Charles E. Bugg, Shobha E. Senadhi, Steven E. Ealick, Graham Darby, F. Raymond Salemme, Tattanahalli L. Nagabhushan, David K. Stammers, Douglas H. Ohlendorf, George S. Nelson, H.M. Einspahr, Brian M. McKeever, Robert S. Snyder, Craig D. Smith, Lawrence J. DeLucas, Manuel A. Navia, Patricia C. Weber, Senadhi Vijay-Kumar
Publikováno v:
Journal of Crystal Growth. 110:302-311
Recent advances in protein crystallography have significantly shortened the time and labor required to determine the three-dimensional structures of macromolecules once good crystals are available. Crystal growth has become a major bottleneck in furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b982afa58f2e99aa8936cf41a34190
https://doi.org/10.1016/0022-0248(91)90899-g
https://doi.org/10.1016/0022-0248(91)90899-g