Ligand-Induced Folding in a Dopamine-Binding DNA Aptamer.

Autor: Kaiyum YA; Department of Chemistry, York University, 4700 Keele St., Toronto, Ontario, M3 J 1P3, Canada., Hoi Pui Chao E; Department of Chemistry, York University, 4700 Keele St., Toronto, Ontario, M3 J 1P3, Canada., Dhar L; Department of Chemistry, York University, 4700 Keele St., Toronto, Ontario, M3 J 1P3, Canada., Shoara AA; Department of Chemistry, York University, 4700 Keele St., Toronto, Ontario, M3 J 1P3, Canada., Nguyen MD; Département de chimie, Université de Sherbrooke, Sherbrooke, Québec, J1 K 2R1, Canada., Mackereth CD; University of Bordeaux, Inserm U1212, CNRS UMR 5320, ARNA, Bordeaux, FR-33000, France., Dauphin-Ducharme P; Département de chimie, Université de Sherbrooke, Sherbrooke, Québec, J1 K 2R1, Canada., Johnson PE; Department of Chemistry, York University, 4700 Keele St., Toronto, Ontario, M3 J 1P3, Canada.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Dec 02; Vol. 25 (23), pp. e202400493. Date of Electronic Publication: 2024 Nov 09.

Amodiaquine Nonspecifically Binds Double Stranded and Three-Way Junction DNA Structures.

Autor: Slavkovic S; Department of Chemistry, York University, 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3., Shoara AA; Department of Chemistry, York University, 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3., Kaiyum YA; Department of Chemistry, York University, 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3., Churcher ZR; Department of Chemistry, York University, 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3., Liu T; Department of Chemistry, McGill University, Montreal, Quebec, Canada, H3A 0B8., Simine L; Department of Chemistry, McGill University, Montreal, Quebec, Canada, H3A 0B8., Johnson PE; Department of Chemistry, York University, 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Jul 15; Vol. 25 (14), pp. e202400116. Date of Electronic Publication: 2024 Jun 16.

Redox Reporter - Ligand Competition to Support Signaling in the Cocaine-Binding Electrochemical Aptamer-Based Biosensor.

Autor: Dauphin-Ducharme P; Département de chimie, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada., Churcher ZR; Chemistry Department, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada., Shoara AA; Chemistry Department, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada., Rahbarimehr E; Département de chimie, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada., Slavkovic S; Chemistry Department, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada., Fontaine N; Département de chimie, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada., Boisvert O; Département de chimie, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada., Johnson PE; Chemistry Department, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Jun 22; Vol. 29 (35), pp. e202300618. Date of Electronic Publication: 2023 May 05.

SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19.

Autor: Ma X; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Liang J; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada., Zhu G; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada., Bhoria P; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada., Shoara AA; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada., MacKeigan DT; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada., Khoury CJ; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Slavkovic S; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada.; Canadian Blood Services Centre for Innovation, Toronto, ON, Canada., Lin L; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Karakas D; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Chen Z; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Canadian Blood Services Centre for Innovation, Toronto, ON, Canada., Prifti V; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Liu Z; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Shen C; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Li Y; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China., Zhang C; CCOA Therapeutics Inc., Toronto, ON, Canada.; Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China., Dou J; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Rousseau Z; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Zhang J; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Ni T; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Lei X; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada., Chen P; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Canadian Blood Services Centre for Innovation, Toronto, ON, Canada., Wu X; Advanced Pharmaceutics & Drug Delivery Laboratory, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Shaykhalishahi H; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada., Mubareka S; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Medical Microbiology and Infectious Disease, Sunnybrook Health Science Centre, Toronto, ON, Canada., Connelly KA; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Cardiology, St. Michael's Hospital, Toronto, ON, Canada., Zhang H; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.; Department of Medical Microbiology and Infectious Disease, Sunnybrook Health Science Centre, Toronto, ON, Canada.; Department of Anesthesiology and Pain Medicine and Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada., Rotstein O; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Department of Surgery, University of Toronto, Toronto, ON, Canada., Ni H; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada.; Canadian Blood Services Centre for Innovation, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.

Publikováno v: Research (Washington, D.C.) [Research (Wash D C)] 2023 Apr 24; Vol. 6, pp. 0124. Date of Electronic Publication: 2023 Apr 24 (Print Publication: 2023).

Visible Fluorescent Light-up Probe for DNA Three-Way Junctions Provides Host-Guest Biosensing Applications.

Autor: Van Riesen AJ; Departments of Chemistry and Toxicology, University of Guelph, Guelph, Ontario N1G 2W1, Canada., Le J; Departments of Chemistry and Toxicology, University of Guelph, Guelph, Ontario N1G 2W1, Canada., Slavkovic S; Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada., Churcher ZR; Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada., Shoara AA; Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada., Johnson PE; Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada., Manderville RA; Departments of Chemistry and Toxicology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.

Publikováno v: ACS applied bio materials [ACS Appl Bio Mater] 2021 Sep 20; Vol. 4 (9), pp. 6732-6741. Date of Electronic Publication: 2021 Aug 18.