Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Shlomi Elias"'
Autor:
Ishay Columbus, Lee Ghindes-Azaria, Ido Michael Herzog, Eliav Blum, Galit Parvari, Yoav Eichen, Yoram Cohen, Eytan Gershonov, Eyal Drug, Sigal Saphier, Shlomi Elias, Boris Smolkin, Yossi Zafrani
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Combined molecular, physicochemical and chemical properties of electrophilic warheads can be applied to create covalent drugs with diverse facets. Here we study these properties in fluorinated diketones (FDKs) and their multicomponent equili
Externí odkaz:
https://doaj.org/article/a860ffa0df394bef8d48ba40fbb9360a
Autor:
Ishay Columbus, Lee Ghindes-Azaria, Ravit Chen, Lea Yehezkel, Orit Redy-Keisar, Gil Fridkin, Dafna Amir, Daniele Marciano, Eyal Drug, Eytan Gershonov, Ziv Klausner, Sigal Saphier, Shlomi Elias, Alexander Pevzner, Yoav Eichen, Galit Parvari, Boris Smolkin, Yossi Zafrani
Publikováno v:
Journal of Medicinal Chemistry. 65:8511-8524
Autor:
Sigal Saphier, Shahaf Katalan, Guy Yacov, Anat Berliner, Orit Redy‐Keisar, Gil Fridkin, Lee Ghindes‐Azaria, Ishay Columbus, Alexander Pevzner, Eyal Drug, Hagit Prihed, Eytan Gershonov, Yoav Eichen, Shlomi Elias, Galit Parvari, Yossi Zafrani
Publikováno v:
Chemistry – A European Journal. 29
Autor:
Sigal, Saphier, Shahaf, Katalan, Guy, Yacov, Anat, Berliner, Orit, Redy-Keisar, Gil, Fridkin, Lee, Ghindes-Azaria, Ishay, Columbus, Alexander, Pevzner, Eyal, Drug, Hagit, Prihed, Eytan, Gershonov, Yoav, Eichen, Shlomi, Elias, Galit, Parvari, Yossi, Zafrani
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany).
Fluorine atoms play an important role in all branches of chemistry and accordingly, it is very important to study their unique and varied effects systematically, in particular, the structure-physicochemical properties relationship. The present study
Autor:
Shlomi Elias, Ishay Columbus, Ofir Shoshanim, Dana Mizrahi, Ravit Chen, Lea Yehezkel, Lee Ghindes‐Azaria, Nissan Ashkenazi, Yossi Zafrani
Publikováno v:
ChemistrySelect. 7
Autor:
Daniele Marciano, Yossi Zafrani, Dafna Amir, Gali Sod-Moriah, Nissan Ashkenazi, Shlomi Elias, Moran Madmon, Dina Yeffet, Eytan Gershonov, Anat Berliner, Shahaf Katalan, Sigal Saphier
Publikováno v:
Journal of Medicinal Chemistry. 62:5628-5637
The effects of the CF2H moiety on H-bond acidity and lipophilicity of various compounds, when attached directly to an aromatic ring or to other functions like alkyls, ethers/thioethers or electron withdrawing groups, are discussed. It was found that
Autor:
Shahaf Katalan, Eytan Gershonov, Yossi Zafrani, Yoav Eichen, Galit Parvari, Lee Ghindes-Azaria, Shlomi Elias, Sigal Saphier, Anat Berliner, Alexander Pevzner, Gil Fridkin, Dafna Amir
Publikováno v:
Journal of medicinal chemistry. 64(8)
Modulation of the H-bond basicity (pKHB) of various functional groups (FGs) by attaching fluorine functions and its impact on lipophilicity and bioisosterism considerations are described. In general, H/F replacement at the α-position to H-bond accep
Autor:
Ishay Columbus, Ravit Chen, Gil Fridkin, Naama Karton-Lifshin, Yossi Zafrani, Shlomi Elias, Moran Madmon, Shahaf Katalan, Lea Yehezkel, Shai Dagan
Publikováno v:
Chemical communications (Cambridge, England). 55(83)
The ability of mono N-methyl-1,4-diazabicyclo[2.2.2]octane fluoride (Me-DABCOF, 1) to act as a bifunctional reagent that effectively and universally neutralizes both the persistent and extremely toxic blister agent HD and the nerve agent VX in nearly
Autor:
Yossi, Zafrani, Gali, Sod-Moriah, Dina, Yeffet, Anat, Berliner, Dafna, Amir, Daniele, Marciano, Shlomi, Elias, Shahaf, Katalan, Nissan, Ashkenazi, Moran, Madmon, Eytan, Gershonov, Sigal, Saphier
Publikováno v:
Journal of medicinal chemistry. 62(11)
The effects of the CF
Autor:
Nissan Ashkenazi, Naama Karton-Lifshin, Lea Yehezkel, Shlomi Elias, Yossi Zafrani, Ishay Columbus
Publikováno v:
Organic letters. 19(12)
The synthesis and properties of a new class of anhydrous quaternary ammonium fluorides, based on the rigid skeleton azabicyclo[2.2.2]octane, is described. Compounds 2a–d were easily prepared by passing the corresponding ammonium iodides over fluori