Zobrazeno 1 - 10
of 432
pro vyhledávání: '"Shizuo Yamada"'
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1246 (2024)
Petit vert (scientific name: Brassica oleracea var. gemmifera DC. × Brassica oleracea var. acephala DC.) is a new variety of vegetable created by crossbreeding kale and brussel sprouts (Brassica oleracea species). The present study aimed to identify
Externí odkaz:
https://doaj.org/article/5949f5b1b1374c349d762b01f173c180
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 51-55 (2022)
The present study aimed to characterize and compare β-adrenoceptors in the rat bladder with those in the heart and lungs of SD rats (8–10 weeks old) using subtype-selective agonists and antagonists in a radioligand binding assay with (-)-[125I]cya
Externí odkaz:
https://doaj.org/article/8124cac8bdc44de7a6842245cb92373e
Autor:
Shizuo Yamada, Shiori Kuraoka, Yoshihiko Ito, Satomi Kagota, Kazumasa Shinozuka, Satomi Onoue
Publikováno v:
Journal of Pharmacological Sciences, Vol 142, Iss 3, Pp 127-130 (2020)
In vitro and in vivo binding sites of [3H]-labeled 5-hydroxymethyltolterodine (5-HMT), a new radioligand for labeling muscarinic receptors in rat tissues were characterized. Specific [3H]5-HMT binding in rat tissues was saturable and of high affinity
Externí odkaz:
https://doaj.org/article/8d01d0ded5f342f3b6586d81af768f49
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 1, Pp 73-78 (2019)
The present study aimed to characterize muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine (5-HMT), and tolterodine in bladder and other tissues of rats after their oral, intravenous, or intravesical administration. Muscarinic r
Externí odkaz:
https://doaj.org/article/e423b64aa554465e82b26cff8f424fe7
Autor:
Shiori Kuraoka, Yoshihiko Ito, Hirokazu Wakuda, Kazumasa Shinozuka, Satomi Onoue, Shizuo Yamada
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 3, Pp 184-189 (2016)
The present study aimed to directly characterize specific binding sites of tritium ([3H])-labeled imidafenacin, a new radioligand for labeling muscarinic receptors, in the bladder and other peripheral or central nervous tissues of rats. Muscarinic re
Externí odkaz:
https://doaj.org/article/4bf7b381133446339e9f790df97a3e90
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 1, Pp 58-63 (2016)
Muscarinic and purinergic (P2X) receptors play critical roles in bladder urothelium under physiological and pathological conditions. Aim of present study was to characterize these receptors in rat bladder urothelium and detrusor muscle using selectiv
Externí odkaz:
https://doaj.org/article/0b2b283941b349e9b91ec2dae4fe8580
Publikováno v:
Molecules, Vol 25, Iss 16, p 3562 (2020)
We designed and synthesized conformationally rigid histamine analogues with a bicyclo[3.1.0]hexane scaffold. All the compounds were selectively bound to the H3 receptor subtype over the H4 receptor subtype. Notably, compound 7 showed potent binding a
Externí odkaz:
https://doaj.org/article/33932173a835424fa3c4ddafc488c21b
Autor:
Hirokazu Wakuda, Shino Miyauchi, Kana Maruyama, Satomi Kagota, Kazuki Nakamura, Keizo Umegaki, Shizuo Yamada, Kazumasa Shinozuka
Publikováno v:
ADMET and DMPK, Vol 3, Iss 1, Pp 77-83 (2015)
The aim of this study was to evaluate the effects of the mitogen-activated protein kinase (MAPK) pathway inhibitors SB203580, CMPD-1, SB239063, SP600125, and FR180204 on the activity of P-glycoprotein (P-gp) and to assess whether the MAPK pathway aff
Externí odkaz:
https://doaj.org/article/a48825de35b249629b23c66bbdc1a859
Autor:
Ayaka Osano, Yoshinari Yokoyama, Hideki Hayashi, Kunihiko Itoh, Takashi Okura, Yoshiharu Deguchi, Yoshihiko Ito, Shizuo Yamada
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 1, Pp 86-91 (2014)
Abstract.: The present study aimed to characterize bladder endothelin-1 (ET-1) receptor binding of clinically used ET-1 receptor antagonists by using [125I]ET-1. The inhibition of specific [125I]ET-1 binding was measured in the presence of ET-1 and i
Externí odkaz:
https://doaj.org/article/b3ae477ebd104c11a3d172594fc32109
Autor:
Akira Yoshida, Shiori Kuraoka, Yoshihiko Ito, Takashi Okura, Yoshiharu Deguchi, Atsushi Otsuka, Seiichiro Ozono, Masayuki Takeda, Keisuke Masuyama, Isao Araki, Shizuo Yamada
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 1, Pp 40-46 (2014)
Abstract.: The aim of the current study was to demonstrate highly specific and direct binding activity of tritium ([3H])-labeled imidafenacin for labeling muscarinic receptors in human bladder and parotid gland. Specific binding of [3H]imidafenacin i
Externí odkaz:
https://doaj.org/article/87ba683de5d14a02ba347ed164ec8e17