Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Shizuko Sei"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Invasive cancers typically evade immune surveillance through profound local and systemic immunosuppression, preventing their elimination or control. Targeting immune interventions to prevent or intercept premalignant lesions, before significant immun
Externí odkaz:
https://doaj.org/article/5523cedbde864175bf9911b2612425bf
Autor:
Sang Beom Lee, Jing Pan, Donghai Xiong, Katie Palen, Bryon Johnson, Ronald A. Lubet, Robert H. Shoemaker, Jeffrey E. Green, Romaine Ingrid Fernando, Shizuko Sei, Ming You, Yian Wang
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has a poor prognosis. TOP2A is a key enzyme in DNA replication and is a therapeutic target for breast and other cancers. TOP2A-specific Th1-promoting epitope
Externí odkaz:
https://doaj.org/article/fec34f822e9940a2a43e7cd6e272efd4
Autor:
Mary L Disis, Sasha E Stanton, Shizuko Sei, Lauren Corulli, Rodmaker Erin, Nicholas Drovetto, Venkatram Atigadda, Clinton Grubbs
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/1b80aa6bf0b3469bb9cb1a41e6e41c1e
Autor:
Yurong Song, Travis D. Kerr, Chelsea Sanders, Lisheng Dai, Shaneen S. Baxter, Brandon Somerville, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Teri M. Plona, Bingfang Xu, Lei Wei, Qiang Hu, Song Liu, Alan Hutson, Baktiar Karim, Sandra Burkett, Simone Difilippantonio, Ligia Pinto, Johannes Gebert, Matthias Kloor, Steven M. Lipkin, Shizuko Sei, Robert H. Shoemaker
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundGenome integrity is essential for the survival of an organism. DNA mismatch repair (MMR) genes (e.g., MLH1, MSH2, MSH6, and PMS2) play a critical role in the DNA damage response pathway for genome integrity maintenance. Germline mutations o
Externí odkaz:
https://doaj.org/article/0d2e5d6b71eb4b909e5643961c4ff61e
Autor:
Shizuko Sei, Aysel Ahadova, Derin B. Keskin, Lena Bohaumilitzky, Johannes Gebert, Magnus von Knebel Doeberitz, Steven M. Lipkin, Matthias Kloor
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Hereditary cancer syndromes (HCS) account for 5~10% of all cancer diagnosis. Lynch syndrome (LS) is one of the most common HCS, caused by germline mutations in the DNA mismatch repair (MMR) genes. Even with prospective cancer surveillance, LS is asso
Externí odkaz:
https://doaj.org/article/78a75d34ee574639a0ad6b8bee1fe57c
Autor:
Jing Pan, Donghai Xiong, Qi Zhang, Katie Palen, Robert H. Shoemaker, Bryon Johnson, Shizuko Sei, Yian Wang, Ming You
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Epidermal growth factor receptor (EGFR) mutations occur in about 50% of lung adenocarcinomas in Asia and about 15% in the US. EGFR mutation-specific inhibitors have been developed and made significant contributions to controlling EGFR mutated non-sma
Externí odkaz:
https://doaj.org/article/a918ea785acb49dcb5cf56c10f7a78df
Autor:
Mofei Huang, Donghai Xiong, Jing Pan, Qi Zhang, Shizuko Sei, Robert H. Shoemaker, Ronald A. Lubet, Luis M. Montuenga, Yian Wang, Barbara S. Slusher, Ming You
Publikováno v:
Advanced Science, Vol 9, Iss 26, Pp n/a-n/a (2022)
Abstract Lung cancer is the leading cause of cancer death worldwide. Vaccination against EGFR can be one of the venues to prevent lung cancer. Blocking glutamine metabolism has been shown to improve anticancer immunity. Here, the authors report that
Externí odkaz:
https://doaj.org/article/9cefa07a6ed841a685c42978f76082d2
Autor:
Jing Pan, Yao Chen, Qi Zhang, Achia Khatun, Katie Palen, Gang Xin, Li Wang, Chuanjia Yang, Bryon D. Johnson, Charles R. Myers, Shizuko Sei, Robert H. Shoemaker, Ronald A. Lubet, Yian Wang, Weiguo Cui, Ming You
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Pan, Chen, Zhang et al. investigated the anti-cancer efficacy of CA170, a small molecule agonist of VISTA, on mouse lung tumorigenesis. When combined with a MHCII-directed KRAS peptide vaccine, the authors reported that CA170 suppressed lung tumor de
Externí odkaz:
https://doaj.org/article/25463f045f454089abc25f6e7b64cc74
Autor:
Qi Zhang, Jing Pan, Donghai Xiong, Yian Wang, Mark Steven Miller, Shizuko Sei, Robert H. Shoemaker, Alberto Izzotti, Ming You
Publikováno v:
Advanced Science, Vol 8, Iss 17, Pp n/a-n/a (2021)
Abstract MicroRNAs are potential candidates for lung cancer prevention and therapy. A major limitation is the lack of an efficient delivery system to directly deliver miRNA to cancer cells while limiting systemic exposure. The delivery of miRNA via i
Externí odkaz:
https://doaj.org/article/15a5fafd15a24128b26bf1acb559b37c
Autor:
Jing Pan, Qi Zhang, Katie Palen, Li Wang, Lifen Qiao, Bryon Johnson, Shizuko Sei, Robert H. Shoemaker, Ronald A. Lubet, Yian Wang, Ming You
Publikováno v:
EBioMedicine, Vol 49, Iss , Pp 72-81 (2019)
Background: No effective approaches to target mutant Kras have yet been developed. Immunoprevention using KRAS-specific antigenic peptides to trigger T cells capable of targeting tumor cells relies heavily on lipid metabolism. To facilitate better TC
Externí odkaz:
https://doaj.org/article/e1e3b2159d9642229f60296e96c23ce8