Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Shizuka Takaku"'
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Various animal and cell culture models of diabetes mellitus (DM) have been established and utilized to study diabetic peripheral neuropathy (DPN). The divergence of metabolic abnormalities among these models makes their etiology complicated despite s
Externí odkaz:
https://doaj.org/article/64c0ee703fbd4580ac8599241321a72d
Autor:
Sho Osonoi, Hiroki Mizukami, Yuki Takeuchi, Hikari Sugawa, Saori Ogasawara, Shizuka Takaku, Takanori Sasaki, Kazuhiro Kudoh, Koichi Ito, Kazunori Sango, Ryoji Nagai, Yasuhiko Yamamoto, Makoto Daimon, Hiroshi Yamamoto, Soroku Yagihashi
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
It is suggested that activation of receptor for advanced glycation end products (RAGE) induces proinflammatory response in diabetic nerve tissues. Macrophage infiltration is invoked in the pathogenesis of diabetic polyneuropathy (DPN), while the asso
Externí odkaz:
https://doaj.org/article/8b94de940bb9438eb3a6b8cf190a6aa7
Autor:
Hideji Yako, Naoko Niimi, Ayako Kato, Shizuka Takaku, Yasuaki Tatsumi, Yasumasa Nishito, Koichi Kato, Kazunori Sango
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Pyruvate functions as a key molecule in energy production and as an antioxidant. The efficacy of pyruvate supplementation in diabetic retinopathy and nephropathy has been shown in animal models; however, its significance in the functional ma
Externí odkaz:
https://doaj.org/article/a6f9d58fa8e244a9b2cbca3a21ee51ce
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were developed as insulinotropic and anti-hyperglycemic agents for the treatment of type 2 diabetes, but their neurotrophic and neuroprotective activities have been receiving increasing attention.
Externí odkaz:
https://doaj.org/article/dc70669a5c40465298d42c8b2374bc28
Autor:
Shizuka Takaku, Kazunori Sango
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9983 (2022)
Oxaliplatin (OHP) is a platinum-based agent that can cause peripheral neuropathy, an adverse effect in which the dorsal root ganglion (DRG) neurons are targeted. Zonisamide has exhibited neuroprotective activities toward adult rat DRG neurons in vitr
Externí odkaz:
https://doaj.org/article/a4b4d41e206840eb976d9bb62974e712
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2971 (2021)
Besides its insulinotropic actions on pancreatic β cells, neuroprotective activities of glucagon-like peptide-1 (GLP-1) have attracted attention. The efficacy of a GLP-1 receptor (GLP-1R) agonist exendin-4 (Ex-4) for functional repair after sciatic
Externí odkaz:
https://doaj.org/article/70f411c16de04480a23f15f2b229c7db
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1031 (2021)
Aldose reductase (AR) is a member of the reduced nicotinamide adenosine dinucleotide phosphate (NADPH)-dependent aldo-keto reductase superfamily. It is also the rate-limiting enzyme of the polyol pathway, catalyzing the conversion of glucose to sorbi
Externí odkaz:
https://doaj.org/article/48f00e8580154bbaa78f0819d2e3003e
Autor:
Hideji Yako, Hidenori Horie, Kazunori Sango, Kunihiko Sakumi, Masami Tsukamoto, Naoko Niimi, Toshihiko Kadoya, Yusaku Nakabeppu, Shizuka Takaku
Publikováno v:
AIMS Molecular Science, Vol 3, Iss 3, Pp 325-337 (2016)
There is growing evidence that galectin-1 (GAL-1) and galectin-3 (GAL-3) are involved in the process of axonal regeneration after injury and the pathogenesis of peripheral neuropathies, but the precise roles of these galectins in the peripheral nervo
Externí odkaz:
https://doaj.org/article/c45a5cb970b0448188317aebcfd14e88
Autor:
Naoko Niimi, Hideji Yako, Ayako Kato, Yasumasa Nishito, Kazunori Sango, Shizuka Takaku, Koichi Kato, Yasuaki Tatsumi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Pyruvate functions as a key molecule in energy production and as an antioxidant. The efficacy of pyruvate supplementation in diabetic retinopathy and nephropathy has been shown in animal models; however, its significance in the functional maintenance
Autor:
Shigenobu Tone, Mineykuki Mizuguchi, Kazunori Sango, Yoshihide Sunada, Hirotake Nishimura, Kazuhiko Watabe, Tatsufumi Murakami, Shizuka Takaku, Takeshi Yokoyama
Publikováno v:
Journal of Neurochemistry. 156:957-966
Patients with transthyretin (TTR)-type familial amyloid polyneuropathy (FAP) typically exhibit sensory dominant polyneuropathy and autonomic neuropathy. However, the molecular pathogenesis of the neuropathy remains unclear. In this study, we characte