Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Shizuka Takagi-Niidome"'
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(43)
γ-Secretase is an intramembrane-cleaving protease that generates the toxic species of the amyloid-β peptide (Aβ) that is responsible for the pathology of Alzheimer disease. The catalytic subunit of γ-secretase is presenilin 1 (PS1), which is a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84454b2875f46a0cc309841587262912
https://pubmed.ncbi.nlm.nih.gov/31527118
https://pubmed.ncbi.nlm.nih.gov/31527118
Publikováno v:
The Journal of Neuroscience. 36:1362-1372
γ-Secretase is an intramembrane-cleaving protease that produces amyloid-β peptide 42 (Aβ42), which is the toxic and aggregation-prone species of Aβ that causes Alzheimer's disease. Here, we used the substituted cysteine accessibility method to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cfee3e410bb1f89ef52a6440da1404
https://doi.org/10.1523/jneurosci.5090-14.2016
https://doi.org/10.1523/jneurosci.5090-14.2016
Autor:
Tetsuo Cai, Satoko Osawa, Takeshi Iwatsubo, Taisuke Tomita, Shizuka Takagi-Niidome, Takeshi Sato, Kanan Morishima, Tomoki Sasaki
Publikováno v:
The Journal of Neuroscience. 35:2646-2656
γ-Secretase is a multisubunit protease complex that is responsible for generating amyloid-β peptides, which are associated with Alzheimer disease. The catalytic subunit of γ-secretase is presenilin 1 (PS1), which contains an initial substrate-bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe9566f774a44170d9d0a69d34a39bd
https://doi.org/10.1523/jneurosci.3164-14.2015
https://doi.org/10.1523/jneurosci.3164-14.2015
Publikováno v:
Alzheimer's & Dementia. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bcdda6a60938e1b124f9ba1d96d5804
https://doi.org/10.1016/j.jalz.2014.05.1113
https://doi.org/10.1016/j.jalz.2014.05.1113
Autor:
Koichi Kato, Yu Kitago, Masamichi Nagae, Emiko Mihara, Shizuka Takagi-Niidome, Zenzaburo Nakata, Terukazu Nogi, Junichi Takagi, Maho Yagi-Utsumi
Publikováno v:
Nature structuralmolecular biology. 22(3)
SorLA is a neuronal sorting receptor considered to be a major risk factor for Alzheimer's disease. We have recently reported that it directs lysosomal targeting of nascent neurotoxic amyloid-β (Aβ) peptides by directly binding Aβ. Here, we determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef9f7c5a3f0431efe546eba4f58b903
https://pubmed.ncbi.nlm.nih.gov/25643321
https://pubmed.ncbi.nlm.nih.gov/25643321
Autor:
Vanessa Schmidt, Junichi Takagi, Thomas E. Willnow, Ernst-Martin Füchtbauer, Annette Füchtbauer, Fan Liao, Tilman Burgert, Safak Caglayan, Shizuka Takagi-Niidome, Anne-Sophie Carlo, David M. Holtzman, Yu Kitago
Publikováno v:
Science Translational Medicine. 6
SORLA/SORL1 is a unique neuronal sorting receptor for the amyloid precursor protein that has been causally implicated in both sporadic and autosomal dominant familial forms of Alzheimer's disease (AD). Brain concentrations of SORLA are inversely corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ada35a76ff1e343e1a53b4080c76fc
https://doi.org/10.1126/scitranslmed.3007747
https://doi.org/10.1126/scitranslmed.3007747
Publikováno v:
Biochemistry. 52(1)
Presenilin 1 (PS1) comprises a catalytic subunit of γ-secretase, which is an intramembrane-cleaving protease responsible for generation of amyloid-β peptides as well as Notch cleavage, the latter being implicated in cancer. We have shown that trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1604a8efa987cd51a1d31e7a8226df85
https://pubmed.ncbi.nlm.nih.gov/23210549
https://pubmed.ncbi.nlm.nih.gov/23210549
Autor:
Shizuka Takagi-Niidome, Tomoki Sasaki, Satoko Osawa, Takeshi Sato, Kanan Morishima, Tetsuo Cai, Takeshi Iwatsubo, Taisuke Tomita
Publikováno v:
Journal of Neuroscience; 2/11/2015, Vol. 35 Issue 6, p2646-2656, 11p
Autor:
Koji Takeo, Shun Tanimura, Takehiro Shinoda, Satoko Osawa, Ivan Krasmirov Zahariev, Naoki Takegami, Yoshiko Ishizuka-Katsura, Naoko Shinya, Shizuka Takagi-Niidome, Aya Tominaga, Noboru Ohsawa, Tomomi Kimura-Someya, Mikako Shirouzu, Satoshi Yokoshima, Shigeyuki Yokoyama, Taisuke Tomita, Takeshi Iwatsubo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 7/22/2014, Vol. 111 Issue 29, p10544-10549, 6p
Autor:
Caglayan, Safak, Shizuka Takagi-Niidome, Fan Liao, Carlo, Anne-Sophie, Schmidt, Vanessa, Burgert, Tilman, Yu Kitago, Füchtbauer, Ernst-Martin, Füchtbauer, Annette, Holtzman, David M., Junichi Takagi, Willnow, Thomas E.
Publikováno v:
Science Translational Medicine; 2/12/2014, Vol. 6 Issue 223, p1-10, 10p