Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shizuka Miura"'
Autor:
Shizuka Miura, Kenichi Horisawa, Tokuko Iwamori, Satoshi Tsujino, Kazuya Inoue, Satsuki Karasawa, Junpei Yamamoto, Yasuyuki Ohkawa, Sayaka Sekiya, Atsushi Suzuki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Hepatocytes play important roles in the liver, but in culture, they immediately lose function and dedifferentiate into progenitor-like cells. Although this unique feature is well-known, the dynamics and mechanisms of hepatocyte dedifferentia
Externí odkaz:
https://doaj.org/article/20c73fdb653b435cb38dddb56b86ecbd
Autor:
Kenichi Horisawa, Shizuka Miura, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Atsushi Suzuki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Direct reprogramming, inducing the conversion of one type of somatic cell into another by the forced expression of defined transcription factors, is a technology with anticipated medical applications. However, due to the many unresolved aspe
Externí odkaz:
https://doaj.org/article/bfc6ddf7927c400780a43d178838c825
Autor:
Misa Minegishi, Takahiro Kuchimaru, Kaori Nishikawa, Takayuki Isagawa, Satoshi Iwano, Kei Iida, Hiromasa Hara, Shizuka Miura, Marika Sato, Shigeaki Watanabe, Akifumi Shiomi, Yo Mabuchi, Hiroshi Hamana, Hiroyuki Kishi, Tatsuyuki Sato, Daigo Sawaki, Shigeru Sato, Yutaka Hanazono, Atsushi Suzuki, Takahide Kohro, Tetsuya Kadonosono, Tomomi Shimogori, Atsushi Miyawaki, Norihiko Takeda, Hirofumi Shintaku, Shinae Kizaka-Kondoh, Satoshi Nishimura
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Cancer cells inevitably interact with neighboring host tissue-resident cells during the process of metastatic colonization, establishing a metastatic niche to fuel their survival, growth, and invasion. However, the underlying mechanisms in t
Externí odkaz:
https://doaj.org/article/c373ff5e397541ef903bbdc92c8afb6e
Autor:
Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The conditions to induce human hepatic progenitor cells from other cell types are unclear. Here, the authors reprogram human endothelial cells to hepatic progenitor cells by expressing FOXA3, HNF1A and HNF6, capable of giving rise to hepatocytes and
Externí odkaz:
https://doaj.org/article/3527de58b192426485e6dd796f38531e
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 183-198 (2018)
Summary: Recent progress in direct lineage reprogramming has enabled the generation of induced hepatocyte-like (iHep) cells and revealed their potential as an alternative to hepatocytes for medical applications. However, the hepatic functions of iHep
Externí odkaz:
https://doaj.org/article/25bdbeb3aeb84845aea83e26da511e68
Autor:
Kenichi Horisawa, Miyako Udono, Wataru Kumamaru, Yoshihiro Ogawa, Yoshihiko Maehara, Masao Nagasaki, Kazuko Ueno, Junpei Yamamoto, Takeshi Goya, Daisuke Saitou, Kanae Matsuda-Ito, Sayaka Sekiya, Hiroki Inada, Mikita Suyama, Shizuka Miura, Atsushi Suzuki, Yasuyuki Ohkawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Recent advances have enabled the direct induction of human tissue-specific stem and progenitor cells from differentiated somatic cells. However, it is not known whether human hepatic progenitor cells (hHepPCs) can be generated from other cell types b
Autor:
Shizuka Miura, Atsushi Suzuki
Publikováno v:
The American Journal of Pathology. 190:1271-1283
Snail is a transcription factor that regulates many cellular events involved in development, homeostasis, and disease. In hepatocellular carcinoma (HCC), Snail induces epithelial-to-mesenchymal transition that confers invasive properties on tumor cel
Autor:
Shizuka, Miura, Atsushi, Suzuki
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2171
Intestinal organoids are useful models for studying the characteristics of intestinal diseases and their treatment. However, a major limiting factor in their usability is the need for donor tissue fragments or pluripotent stem cells to generate the o
Autor:
Shizuka Miura, Atsushi Suzuki
Publikováno v:
Methods in Molecular Biology ISBN: 9781071607466
Intestinal organoids are useful models for studying the characteristics of intestinal diseases and their treatment. However, a major limiting factor in their usability is the need for donor tissue fragments or pluripotent stem cells to generate the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c95690c188765076a88c29fae5f33826
https://doi.org/10.1007/978-1-0716-0747-3_14
https://doi.org/10.1007/978-1-0716-0747-3_14
Autor:
Atsushi Suzuki, Shizuka Miura
Publikováno v:
Development, Growth & Differentiation. 60:387-392
The intestine has fundamental functions for the maintenance of homeostasis, including food digestion and nutrient/water absorption. Although the lumen of the intestine is always exposed to pathogens, intestinal epithelial cells form monolayer sheets